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    Pcyt2 phosphate cytidylyltransferase 2, ethanolamine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89841, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pcyt2provided by RGD
    Official Full Name
    phosphate cytidylyltransferase 2, ethanolamineprovided by RGD
    Primary source
    RGD:619970
    See related
    EnsemblRapid:ENSRNOG00000036684 AllianceGenome:RGD:619970
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ET
    Summary
    Enables ethanolamine-phosphate cytidylyltransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 82. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 637.3), Kidney (RPKM 196.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcyt2 in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106387150..106394500, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105888769..105896182, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109788348..109795743, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene neuropeptide B Neighboring gene sirtuin 7 Neighboring gene MAF bZIP transcription factor G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol. Bleijerveld OB, et al. Biochem J, 2004 May 1. PMID 14759225, Free PMC Article
    2. Cloning and expression of CTP:phosphoethanolamine cytidylyltransferase cDNA from rat liver. Bladergroen BA, et al. Biochem J, 1999 Oct 1. PMID 10493918, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. supply of CDPethanolamine, via the expression level of ECT, is an important factor governing the rate of PtdEtn biosynthesis in mammalian cells, under the condition that the amount of DAG is not limiting
      Title: Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93299

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ethanolamine-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ethanolamine-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ethanolamine-phosphate cytidylyltransferase
    Names
    CTP:phopshoethanolamine cytidylyltransferase
    CTP:phosphoethanolamine cytidylyltransferase
    phosphorylethanolamine transferase
    NP_446020.1
    XP_006247997.1
    XP_038942930.1
    XP_038942932.1
    XP_038942933.1
    XP_063126073.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053568.2 → NP_446020.1  ethanolamine-phosphate cytidylyltransferase

      See identical proteins and their annotated locations for NP_446020.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O88637, Q6AZ30
      UniProtKB/TrEMBL
      A0A8I6AET7, A6HLG4
      Related
      ENSRNOP00000051835.4, ENSRNOT00000054952.6
      Conserved Domains (1) summary
      PTZ00308
      Location:22 → 390
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106387150..106394500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247935.5 → XP_006247997.1  ethanolamine-phosphate cytidylyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006247997.1

      UniProtKB/TrEMBL
      A0A8L2QPS4, A6HLG3
      Conserved Domains (1) summary
      PTZ00308
      Location:22 → 372
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    2. XM_063270003.1 → XP_063126073.1  ethanolamine-phosphate cytidylyltransferase isoform X3

      Related
      ENSRNOP00000108266.1, ENSRNOT00000131310.1

    3. XM_039087002.2 → XP_038942930.1  ethanolamine-phosphate cytidylyltransferase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZT93, A0A8I6AET7
      Related
      ENSRNOP00000082255.1, ENSRNOT00000109346.2
      Conserved Domains (1) summary
      PTZ00308
      Location:2 → 371
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    4. XM_039087004.2 → XP_038942932.1  ethanolamine-phosphate cytidylyltransferase isoform X4

      Conserved Domains (1) summary
      cd02173
      Location:34 → 186
      ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)

    5. XM_039087005.2 → XP_038942933.1  ethanolamine-phosphate cytidylyltransferase isoform X5

      UniProtKB/TrEMBL
      A0A8I6AET7
      Conserved Domains (1) summary
      PTZ00308
      Location:22 → 345
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional

    RNA

    1. XR_005489961.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88637.1 GenPept UniProtKB/Swiss-Prot:O88637

    Gene LinkOut

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