U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Atp8a2 ATPase phospholipid transporting 8A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691889, updated on 28-Oct-2024

    Summary

    Official Symbol
    Atp8a2provided by RGD
    Official Full Name
    ATPase phospholipid transporting 8A2provided by RGD
    Primary source
    RGD:1594597
    See related
    EnsemblRapid:ENSRNOG00000008053 AllianceGenome:RGD:1594597
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aminophospholipid flippase activity. Acts upstream of or within neuron projection development. Predicted to be located in several cellular components, including Golgi apparatus; endosome; and nucleoplasm. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 4. Orthologous to human ATP8A2 (ATPase phospholipid transporting 8A2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 50.5), Testes (RPKM 50.3) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Atp8a2 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (37993507..38526408, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (33817309..34350193, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (39955689..40488737, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S9, pseudogene 9 Neighboring gene eukaryotic translation initiation factor 4B, pseudogene 1 Neighboring gene shisa family member 2 Neighboring gene uncharacterized LOC134481976 Neighboring gene ETS-related transcription factor Elf-2 pseudogene Neighboring gene uncharacterized LOC103693635 Neighboring gene nucleoporin 58 Neighboring gene myotubularin related protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aminophospholipid flippase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of light stimulus involved in visual perception ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within involuntary skeletal muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurofilament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular process controlling posture ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to auditory stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina layer formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skin development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phospholipid-transporting ATPase IB
    Names
    ATPase, aminophospholipid transporter, class I, type 8A, member 2
    NP_001414379.1
    XP_003751540.1
    XP_038949921.1
    XP_038949922.1
    XP_038949924.1
    XP_038949925.1
    XP_038949926.1
    XP_038949927.1
    XP_038949928.1
    XP_038949929.1
    XP_038949930.1
    XP_038949931.1
    XP_038949932.1
    XP_038949933.1
    XP_063130743.1
    XP_063130744.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427450.1NP_001414379.1  phospholipid-transporting ATPase IB

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZQP3
      Related
      ENSRNOP00000095034.2, ENSRNOT00000116305.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      37993507..38526408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093999.2XP_038949927.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:281078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    2. XM_039093996.2XP_038949924.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:281078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    3. XM_039093997.2XP_038949925.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:281078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    4. XM_039094002.2XP_038949930.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:281078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    5. XM_039094003.1XP_038949931.1  phospholipid-transporting ATPase IB isoform X6

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:681043
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    6. XM_003751492.5XP_003751540.1  phospholipid-transporting ATPase IB isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Related
      ENSRNOP00000080718.2, ENSRNOT00000099280.2
      Conserved Domains (6) summary
      TIGR01652
      Location:681106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:125342
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:506604
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:57119
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8481099
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:816845
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    7. XM_039093993.1XP_038949921.1  phospholipid-transporting ATPase IB isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3Z6, A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:681118
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    8. XM_039093998.1XP_038949926.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:281078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    9. XM_039093994.2XP_038949922.1  phospholipid-transporting ATPase IB isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLF5
      Conserved Domains (1) summary
      TIGR01652
      Location:671117
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    10. XM_039094000.2XP_038949928.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:281078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    11. XM_063274673.1XP_063130743.1  phospholipid-transporting ATPase IB isoform X4

    12. XM_039094001.2XP_038949929.1  phospholipid-transporting ATPase IB isoform X5

      UniProtKB/TrEMBL
      A0A8I6AGF0
      Conserved Domains (1) summary
      TIGR01652
      Location:281078
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    13. XM_063274674.1XP_063130744.1  phospholipid-transporting ATPase IB isoform X7

    14. XM_039094004.2XP_038949932.1  phospholipid-transporting ATPase IB isoform X8

      Conserved Domains (1) summary
      TIGR01652
      Location:68806
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    15. XM_039094005.2XP_038949933.1  phospholipid-transporting ATPase IB isoform X9

      Conserved Domains (1) summary
      TIGR01652
      Location:68760
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase