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Nlgn1 neuroligin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116647, updated on 2-Nov-2024

Summary

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Official Symbol: Nlgn1provided by RGD
Official Full Name: neuroligin 1provided by RGD
Primary source: RGD:621117
See related: EnsemblRapid:ENSRNOG00000032576 AllianceGenome:RGD:621117
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including cell adhesion molecule binding activity; identical protein binding activity; and neurexin family protein binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of cellular component organization; and synapse organization. Acts upstream of or within synapse organization. Located in several cellular components, including Golgi apparatus; dendrite; and filopodium tip. Is active in glutamatergic synapse and postsynaptic specialization membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN1 (neuroligin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 197.5) See more
Orthologs: human mouse all
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Genomic context

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See Nlgn1 in Genome Data Viewer

Location:: 2q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (110184987..111110316, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (108256236..109181530, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (111057291..111973681, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis.
Title: Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis.
Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity.
Title: Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity.
Results showed that in pyramidal and interneurons, neuroligin 1 and neuroligin 3 were involved in excitatory synapse formation, and neuroligin 2 in GABAergic synapse formation.
Title: Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons.
To characterize the possible contribution of NLGN1 to inflammatory pain, the present study analyzed the changes of NLGN1 expression after intraplantar injection of complete Freund's adjuvant (CFA). Our data revealed an activity-dependent recruitment of NLGN1 into synapses, which was essential for NMDAR hyperfunction and pain hypersensitivity.
Title: Activity-dependent Synaptic Recruitment of Neuroligin 1 in Spinal Dorsal Horn Contributed to Inflammatory Pain.
downregulation of spinal neuroligin1 expression may ameliorate postoperative pain through inhibiting neuroligin1/PSD-95 interaction and synaptic targeting of GluA1 subunit.
Title: Downregulation of neuroligin1 ameliorates postoperative pain through inhibiting neuroligin1/postsynaptic density 95-mediated synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluA1 subunits in rat dorsal horns.
Following endoplasmic reticulum exit, the AMPA-type glutamate receptor GluA1 and neuroligin 1 undergo spatially restricted entry into the dendritic secretory pathway and accumulate in recycling endosomes (REs) located in dendrites and spines before reaching the plasma membrane.
Title: Golgi-independent secretory trafficking through recycling endosomes in neuronal dendrites and spines.
We concluded that NLGN1 gene and protein expression is higher in the motor frontal cortex, hippocampus and in the prefrontal cortex in the forced swimming animal model of depression in WKy rats
Title: Hippocampal and motor fronto-cortical neuroligin1 is increased in an animal model of depression.
Neuroligin-1 and neurexin II were both expressed in the Enteric Nervous System (ENS) and have temporal correlation with the development of ENS, during which neuronal intestinal malformations (NIM) may occur due to their disruptions and consequent abnormal ENS development.
Title: Abundance and Significance of Neuroligin-1 and Neurexin II in the Enteric Nervous System of Embryonic Rats.
the expression of NL1 and its binding partner neurexin-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats.
Title: Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability.
The soluble extracellular fragment of neuroligin-1 protects synapses in neurons damaged by ABETA oligomers.
Title: The soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF394648 (e-PCR)
- UniSTS:244809

D2Rat335 (e-PCR), detects polymorphism
- UniSTS:227469

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurexin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurexin family protein binding	IEA Inferred from Electronic Annotation more info
enables neurexin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurexin family protein binding	ISO Inferred from Sequence Orthology more info
enables neurexin family protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in AMPA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in NMDA glutamate receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion involved in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeletal matrix organization at active zone	IEA Inferred from Electronic Annotation more info
involved_in cytoskeletal matrix organization at active zone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeletal matrix organization at active zone	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in inhibitory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of synapse structure	NAS Non-traceable Author Statement more info	PubMed
involved_in membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurexin clustering involved in presynaptic membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in neurexin clustering involved in presynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in neurexin clustering involved in presynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in neuron cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in neuron cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in neuron projection arborization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in neuronal ion channel clustering	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of dendritic spine development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuromuscular synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of neuron projection development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of presynaptic active zone assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ruffle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic density protein 95 clustering	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic density protein 95 clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density protein 95 clustering	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density protein 95 clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic membrane assembly	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic membrane assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in postsynaptic specialization assembly	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic specialization assembly	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in receptor localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in receptor localization to synapse	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of AMPA receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of NMDA receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of NMDA receptor activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of NMDA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of NMDA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of nervous system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse organization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of presynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of respiratory gaseous exchange by nervous system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within synapse organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle clustering	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle clustering	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle targeting	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle targeting	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle targeting	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptic vesicle transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	IEA Inferred from Electronic Annotation more info
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in terminal button organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IC Inferred by Curator more info	PubMed
located_in excitatory synapse	NAS Non-traceable Author Statement more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in inhibitory synapse	NAS Non-traceable Author Statement more info	PubMed
located_in neuromuscular junction	NAS Non-traceable Author Statement more info	PubMed
located_in neuron to neuron synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuroligin-1

Names: neuroligin I

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053868.2 → NP_446320.1 neuroligin-1 precursor

See identical proteins and their annotated locations for NP_446320.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002, U22952

UniProtKB/Swiss-Prot

Q62765

Related

ENSRNOP00000103300.1, ENSRNOT00000150531.1

Conserved Domains (1) summary

pfam00135
Location:53 → 626

COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

110184987..111110316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281164.1 → XP_063137234.1 neuroligin-1 isoform X6
XM_039101572.2 → XP_038957500.1 neuroligin-1 isoform X1

Conserved Domains (1) summary

pfam00135
Location:52 → 646

COesterase; Carboxylesterase family
XM_039101573.2 → XP_038957501.1 neuroligin-1 isoform X1

Conserved Domains (1) summary

pfam00135
Location:52 → 646

COesterase; Carboxylesterase family
XM_063281162.1 → XP_063137232.1 neuroligin-1 isoform X6
XM_063281158.1 → XP_063137228.1 neuroligin-1 isoform X3

UniProtKB/TrEMBL

A0A8I6GKV2
XM_063281159.1 → XP_063137229.1 neuroligin-1 isoform X4

UniProtKB/Swiss-Prot

Q62765
XM_039101569.2 → XP_038957497.1 neuroligin-1 isoform X1

Conserved Domains (1) summary

pfam00135
Location:52 → 646

COesterase; Carboxylesterase family
XM_063281163.1 → XP_063137233.1 neuroligin-1 isoform X6

Related

ENSRNOP00000075793.2, ENSRNOT00000092660.3
XM_039101570.2 → XP_038957498.1 neuroligin-1 isoform X1

Conserved Domains (1) summary

pfam00135
Location:52 → 646

COesterase; Carboxylesterase family
XM_039101571.2 → XP_038957499.1 neuroligin-1 isoform X1

Conserved Domains (1) summary

pfam00135
Location:52 → 646

COesterase; Carboxylesterase family
XM_063281161.1 → XP_063137231.1 neuroligin-1 isoform X6
XM_063281160.1 → XP_063137230.1 neuroligin-1 isoform X5
XM_063281157.1 → XP_063137227.1 neuroligin-1 isoform X3

UniProtKB/TrEMBL

A0A8I6GKV2
XM_039101568.2 → XP_038957496.1 neuroligin-1 isoform X1

Conserved Domains (1) summary

pfam00135
Location:52 → 646

COesterase; Carboxylesterase family
XM_063281165.1 → XP_063137235.1 neuroligin-1 isoform X7
XM_039101574.2 → XP_038957502.1 neuroligin-1 isoform X1
XM_017590590.3 → XP_017446079.1 neuroligin-1 isoform X7

UniProtKB/Swiss-Prot

Q62765

Conserved Domains (1) summary

pfam00135
Location:52 → 597

COesterase; Carboxylesterase family
XM_017590583.3 → XP_017446072.1 neuroligin-1 isoform X6

UniProtKB/Swiss-Prot

Q62765

Conserved Domains (1) summary

pfam00135
Location:53 → 606

COesterase; Carboxylesterase family
XM_039101577.2 → XP_038957505.1 neuroligin-1 isoform X3

UniProtKB/TrEMBL

A0A8I6GKV2

Related

ENSRNOP00000094652.1, ENSRNOT00000107850.2

Conserved Domains (1) summary

pfam00135
Location:52 → 626

COesterase; Carboxylesterase family
XM_039101576.2 → XP_038957504.1 neuroligin-1 isoform X2

Related

ENSRNOP00000099159.1, ENSRNOT00000142652.1
XM_039101567.2 → XP_038957495.1 neuroligin-1 isoform X1
XM_039101575.2 → XP_038957503.1 neuroligin-1 isoform X1

Conserved Domains (1) summary

pfam00135
Location:52 → 646

COesterase; Carboxylesterase family