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    Ccna1 cyclin A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295052, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ccna1provided by RGD
    Official Full Name
    cyclin A1provided by RGD
    Primary source
    RGD:1310639
    See related
    EnsemblRapid:ENSRNOG00000014052 AllianceGenome:RGD:1310639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be part of cyclin A1-CDK2 complex and cyclin A2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human CCNA1 (cyclin A1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Testes (RPKM 95.9), Muscle (RPKM 24.2) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccna1 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (141383352..141428205, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (139231738..139278066, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (144456689..144503570, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485915 Neighboring gene uncharacterized LOC134485735 Neighboring gene uncharacterized LOC134485736 Neighboring gene uncharacterized LOC134485916 Neighboring gene spartin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 17β-Estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules. Bois C, et al. J Mol Endocrinol, 2012 Apr. PMID 22180637
    2. Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis. Wegiel B, et al. J Natl Cancer Inst, 2008 Jul 16. PMID 18612129, Free PMC Article
    3. Cyclin A1 expression in leukemia and normal hematopoietic cells. Yang R, et al. Blood, 1999 Mar 15. PMID 10068680
    4. Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Diederichs S, et al. Int J Cancer, 2005 Aug 20. PMID 15800920
    5. Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells. Katabami M, et al. J Biol Chem, 2005 Apr 29. PMID 15737994

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that cyclin A1 and cyclin B1 gene expression is controlled by E(2) at a concentration of 10(-9)uM only in stages IX-I of spermatogenesis.
      Title: 17β-Estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules.
    2. Oxidized low density lipoprotein induces cyclin A synthesis in a process involving ERK, JNK and NFkappaB
      Title: Oxidized low density lipoprotein induces cyclin A synthesis. Involvement of ERK, JNK and NFkappaB.
    3. analysis of expression of Cyclin D1, E, A and B1 in neurons of cerebral cortex and hippocampus
      Title: The expression of cyclins in neurons of rats after focal cerebral ischemia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin A1-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cyclin A2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011949.1 → NP_001011949.1  cyclin-A1

      See identical proteins and their annotated locations for NP_001011949.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079234
      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Related
      ENSRNOP00000039931.3, ENSRNOT00000040002.6
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      141383352..141428205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102014.2 → XP_038957942.1  cyclin-A1 isoform X5

      Conserved Domains (2) summary
      cd20560
      Location:38 → 200
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:204 → 326
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    2. XM_063281585.1 → XP_063137655.1  cyclin-A1 isoform X4

    3. XM_017590749.3 → XP_017446238.1  cyclin-A1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    4. XM_017590750.3 → XP_017446239.1  cyclin-A1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    5. XM_008760987.4 → XP_008759209.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_008759209.1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    6. XM_063281583.1 → XP_063137653.1  cyclin-A1 isoform X3

    7. XM_006232361.5 → XP_006232423.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_006232423.1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    8. XM_063281584.1 → XP_063137654.1  cyclin-A1 isoform X4

    9. XM_063281582.1 → XP_063137652.1  cyclin-A1 isoform X3

    10. XM_063281579.1 → XP_063137649.1  cyclin-A1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLN2, A6JVE2
      Related
      ENSRNOP00000078779.1, ENSRNOT00000095893.2

    11. XM_006232360.5 → XP_006232422.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_006232422.1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    12. XM_006232359.5 → XP_006232421.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_006232421.1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    13. XM_008760988.4 → XP_008759210.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_008759210.1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    14. XM_063281581.1 → XP_063137651.1  cyclin-A1 isoform X3

    15. XM_063281580.1 → XP_063137650.1  cyclin-A1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLN2, A6JVE2

    16. XM_039102011.2 → XP_038957939.1  cyclin-A1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLN2, A6JVE2
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cl40454
      Location:298 → 360
      CYCLIN_SF; Cyclin box fold superfamily

    17. XM_039102012.2 → XP_038957940.1  cyclin-A1 isoform X3

      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20563
      Location:274 → 396
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
      cl40454
      Location:132 → 270
      CYCLIN_SF; Cyclin box fold superfamily

    18. XM_039102010.2 → XP_038957938.1  cyclin-A1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AY13
      UniProtKB/TrEMBL
      A6JVE3
      Conserved Domains (3) summary
      pfam16500
      Location:27 → 101
      Cyclin_N2; N-terminal region of cyclin_N
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY13.1 GenPept UniProtKB/Swiss-Prot:Q6AY13

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