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    Calcoco1 calcium binding and coiled coil domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246047, updated on 2-Nov-2024

    Summary

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    Symbol
    Calcoco1provided by RGD
    Full Name
    calcium binding and coiled coil domain 1provided by RGD
    Primary source
    RGD:619812
    See related
    EnsemblRapid:ENSRNOG00000015447 AllianceGenome:RGD:619812
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; beta-catenin binding activity; and nuclear receptor coactivator activity. Predicted to be involved in nuclear receptor-mediated steroid hormone signaling pathway; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin; cytosol; and nucleus. Orthologous to human CALCOCO1 (calcium binding and coiled-coil domain 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 204.6), Thymus (RPKM 160.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Calcoco1 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135713208..135728044, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133834705..133849515, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144307562..144322253, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene activating transcription factor 7 Neighboring gene uncharacterized LOC120093744 Neighboring gene ATP synthase membrane subunit c locus 2 Neighboring gene chondrogenesis-associated transcript Neighboring gene tubulin cofactor A like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Kim JH, et al. Mol Cell, 2003 Dec. PMID 14690606
    2. Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription. Kim JH, et al. J Biol Chem, 2004 Nov 26. PMID 15383530
    3. Cellular signaling mediated by calphoglin-induced activation of IPP and PGM. Takahashi K, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522220
    4. CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. Mizuta S, et al. Genes Cells, 2014 Jan. PMID 24245781, Free PMC Article
    5. Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1. Yang CK, et al. J Biol Chem, 2006 Feb 10. PMID 16344550, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1536, MGC93160

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in nuclear receptor-mediated steroid hormone signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear receptor-mediated steroid hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-binding and coiled-coil domain-containing protein 1
    Names
    calcium-binding and coiled-coil domain-containing protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139190.2 → NP_631929.2  calcium-binding and coiled-coil domain-containing protein 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q66HR5, Q8R443
      UniProtKB/TrEMBL
      A0A8L2QVZ6, A6KCX8
      Related
      ENSRNOP00000021522.3, ENSRNOT00000021523.8
      Conserved Domains (3) summary
      pfam07888
      Location:122 → 584
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:15 → 118
      SKICH; SKICH domain
      cd21967
      Location:654 → 682
      Zn-C2H2_CALCOCO1; C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135713208..135728044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262991.1 → XP_063119061.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q66HR5, Q8R443
      UniProtKB/TrEMBL
      A6KCX8

    2. XM_039078406.2 → XP_038934334.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0S1, A0A8L2QVZ6
      Related
      ENSRNOP00000071559.1, ENSRNOT00000089290.3
      Conserved Domains (3) summary
      pfam07888
      Location:122 → 584
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:15 → 118
      SKICH; SKICH domain
      cd21967
      Location:678 → 706
      Zn-C2H2_CALCOCO1; C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins

    3. XM_063262990.1 → XP_063119060.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0S1

    4. XM_063262992.1 → XP_063119062.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q66HR5, Q8R443
      UniProtKB/TrEMBL
      A6KCX8

    5. XM_039078407.2 → XP_038934335.1  calcium-binding and coiled-coil domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0S1, A0A8L2QVZ6
      Conserved Domains (3) summary
      pfam07888
      Location:122 → 584
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      pfam17751
      Location:15 → 118
      SKICH; SKICH domain
      cd21967
      Location:678 → 706
      Zn-C2H2_CALCOCO1; C2H2-type zinc binding domain found in calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HR5.1 GenPept UniProtKB/Swiss-Prot:Q66HR5

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