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    Cnpy2 canopy FGF signaling regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685814, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cnpy2provided by RGD
    Official Full Name
    canopy FGF signaling regulator 2provided by RGD
    Primary source
    RGD:1589072
    See related
    EnsemblRapid:ENSRNOG00000003549 AllianceGenome:RGD:1589072
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem4
    Summary
    Predicted to be active in endoplasmic reticulum. Orthologous to human CNPY2 (canopy FGF signaling regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 380.5), Kidney (RPKM 366.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cnpy2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1332293..1338081)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (748877..754352)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2737674..2744321)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene interleukin 23 subunit alpha Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene citrate synthase Neighboring gene coenzyme Q10A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap). Do HT, et al. J Biol Chem, 2012 Apr 13. PMID 22378787, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156825

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of low-density lipoprotein receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of positive regulation of low-density lipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein canopy homolog 2
    Names
    canopy 2 homolog
    transmembrane protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077585.1 → NP_001071053.1  protein canopy homolog 2 precursor

      See identical proteins and their annotated locations for NP_001071053.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126101
      UniProtKB/TrEMBL
      A0A8I6APW9, A0A8I6GKM8, A0JN30
      Related
      ENSRNOP00000096727.1, ENSRNOT00000106896.2
      Conserved Domains (1) summary
      pfam11938
      Location:27 → 165
      DUF3456; TLR4 regulator and MIR-interacting MSAP

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1332293..1338081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264262.1 → XP_063120332.1  protein canopy homolog 2 isoform X1

    2. XM_039079903.2 → XP_038935831.1  protein canopy homolog 2 isoform X2

      Conserved Domains (1) summary
      pfam11938
      Location:1 → 113
      DUF3456; TLR4 regulator and MIR-interacting MSAP
    Nucleotide Protein Strain
    Heading Accession and Version

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