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    DUOX2 dual oxidase 2 [ Pteropus giganteus (Indian flying fox) ]

    Gene ID: 120622695, updated on 30-Mar-2024

    Summary

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    Gene symbol
    DUOX2
    Gene description
    dual oxidase 2
    See related
    EnsemblRapid:ENSPGIG00000015609
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pteropus giganteus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Pteropodinae; Pteropus
    Orthologs
    human mouse all
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    Genomic context

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    See DUOX2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    100 current Ma_sr-lr_union100 (GCF_902729225.1) Unplaced Scaffold NW_024349801.1 (25217852..25237325)

    NW_024349801.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase maturation factor 2 Neighboring gene sorbitol dehydrogenase Neighboring gene 40S ribosomal protein S29-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024349801 Unplaced Scaffold Reference Ma_sr-lr_union100

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables superoxide-generating NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NADPH oxidase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual oxidase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Pteropus giganteus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Ma_sr-lr_union100

    Genomic

    1. NW_024349801.1 Reference Ma_sr-lr_union100

      Range
      25217852..25237325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039888255.1 → XP_039744189.1  dual oxidase 2

      Related
      ENSPGIP00000013341.1, ENSPGIT00000020464.1
      Conserved Domains (4) summary
      cd06186
      Location:1271 → 1544
      NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
      PLN02631
      Location:1118 → 1406
      PLN02631; ferric-chelate reductase
      cd09820
      Location:38 → 594
      dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
      cd00051
      Location:824 → 885
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version

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