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    kmt2ca lysine (K)-specific methyltransferase 2Ca [ Carcharodon carcharias (great white shark) ]

    Gene ID: 121276205, updated on 22-Mar-2024

    Summary

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    Gene symbol
    kmt2ca
    Gene description
    lysine (K)-specific methyltransferase 2Ca
    See related
    EnsemblRapid:ENSCHSG00020013327
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Carcharodon carcharias
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Galeomorphii; Galeoidea; Lamniformes; Alopiidae; Carcharodon
    Orthologs
    human zebrafish all
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    Genomic context

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    See kmt2ca in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    100 current sCarCar2.pri (GCF_017639515.1) 3 NC_054469.1 (27149768..27621698, complement)

    Chromosome 3 - NC_054469.1Genomic Context describing neighboring genes Neighboring gene THAP domain-containing protein 2-like Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) Neighboring gene uncharacterized LOC121275847 Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 2 Neighboring gene actin related protein 3B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_054469.1 Chromosome 3 Reference sCarCar2.pri Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2C

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Carcharodon carcharias Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference sCarCar2.pri Primary Assembly

    Genomic

    1. NC_054469.1 Reference sCarCar2.pri Primary Assembly

      Range
      27149768..27621698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041184363.1 → XP_041040297.1  histone-lysine N-methyltransferase 2C isoform X3

      Conserved Domains (15) summary
      smart00541
      Location:4761 → 4804
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1661 → 1714
      HMG; high mobility group
      smart00542
      Location:4810 → 4897
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1848 → 2430
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:2813 → 3022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:3317 → 3414
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      sd00025
      Location:934 → 958
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:984 → 1030
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1061 → 1111
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4602 → 4706
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4954 → 5106
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    2. XM_041184366.1 → XP_041040300.1  histone-lysine N-methyltransferase 2C isoform X5

      Related
      ENSCHSP00020023584.1, ENSCHST00020026136.1
      Conserved Domains (14) summary
      smart00541
      Location:4726 → 4769
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1626 → 1679
      HMG; high mobility group
      smart00542
      Location:4775 → 4862
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1813 → 2395
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:2778 → 2987
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:3282 → 3379
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:949 → 995
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1026 → 1076
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4567 → 4671
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4923 → 5075
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    3. XM_041184360.1 → XP_041040294.1  histone-lysine N-methyltransferase 2C isoform X1

      Conserved Domains (15) summary
      smart00541
      Location:4761 → 4804
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1661 → 1714
      HMG; high mobility group
      smart00542
      Location:4810 → 4897
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1848 → 2430
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:2813 → 3022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:3317 → 3414
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      sd00025
      Location:934 → 958
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:984 → 1030
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1061 → 1111
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4602 → 4706
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4958 → 5110
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    4. XM_041184365.1 → XP_041040299.1  histone-lysine N-methyltransferase 2C isoform X4

      Related
      ENSCHSP00020023262.1, ENSCHST00020025805.1
      Conserved Domains (15) summary
      smart00541
      Location:4745 → 4788
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1645 → 1698
      HMG; high mobility group
      smart00542
      Location:4794 → 4881
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1832 → 2414
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:2797 → 3006
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:3301 → 3398
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      sd00025
      Location:934 → 958
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:984 → 1030
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1061 → 1111
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4586 → 4690
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4942 → 5094
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    5. XM_041184362.1 → XP_041040296.1  histone-lysine N-methyltransferase 2C isoform X2

      Related
      ENSCHSP00020022966.1, ENSCHST00020025495.1
      Conserved Domains (15) summary
      smart00541
      Location:4760 → 4803
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1661 → 1714
      HMG; high mobility group
      smart00542
      Location:4809 → 4896
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1848 → 2430
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:2813 → 3022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:3317 → 3414
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      sd00025
      Location:934 → 958
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:984 → 1030
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1061 → 1111
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4601 → 4705
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4957 → 5109
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    6. XM_041184367.1 → XP_041040301.1  histone-lysine N-methyltransferase 2C isoform X6

      Conserved Domains (14) summary
      smart00541
      Location:4160 → 4203
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1661 → 1714
      HMG; high mobility group
      smart00542
      Location:4209 → 4296
      FYRC; FY-rich domain, C-terminal region
      COG5271
      Location:2212 → 2421
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:2716 → 2813
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      sd00025
      Location:934 → 958
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:984 → 1030
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1061 → 1111
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4001 → 4105
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4357 → 4509
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    7. XM_041184368.1 → XP_041040302.1  histone-lysine N-methyltransferase 2C isoform X7

      Conserved Domains (15) summary
      smart00541
      Location:4760 → 4803
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1661 → 1714
      HMG; high mobility group
      smart00542
      Location:4809 → 4896
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1848 → 2430
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:2813 → 3022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:3317 → 3414
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      sd00025
      Location:934 → 958
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:984 → 1030
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1061 → 1111
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4601 → 4705
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4953 → 5105
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    8. XM_041184361.1 → XP_041040295.1  histone-lysine N-methyltransferase 2C isoform X1

      Conserved Domains (15) summary
      smart00541
      Location:4761 → 4804
      FYRN; FY-rich domain, N-terminal region
      smart00398
      Location:1661 → 1714
      HMG; high mobility group
      smart00542
      Location:4810 → 4897
      FYRC; FY-rich domain, C-terminal region
      PHA03247
      Location:1848 → 2430
      PHA03247; large tegument protein UL36; Provisional
      COG5271
      Location:2813 → 3022
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      PRK00409
      Location:3317 → 3414
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      sd00025
      Location:934 → 958
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      cd15509
      Location:340 → 385
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:465 → 516
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:984 → 1030
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15514
      Location:1061 → 1111
      PHD6_KMT2C_like; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 5 found in KMT2D
      cd15594
      Location:387 → 432
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15666
      Location:4602 → 4706
      ePHD2_KMT2C_like; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd19171
      Location:4958 → 5110
      SET_KMT2C_2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins
      cl22851
      Location:244 → 327
      PHD_SF; PHD finger superfamily

    RNA

    1. XR_005942627.1 RNA Sequence

    2. XR_005942628.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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