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    adar.S adenosine deaminase, RNA-specific S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 397992, updated on 4-Nov-2024

    Summary

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    Official Symbol
    adar.S
    Official Full Name
    adenosine deaminase, RNA-specific S homeolog
    Primary source
    Xenbase:XB-GENE-866546
    Locus tag
    XELAEV_18042915mg
    See related
    EnsemblRapid:ENSXLAG00005031148 AllianceGenome:Xenbase:XB-GENE-866546
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    adar; adar1; dsRAD; dsRAD-1
    Summary
    Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to act upstream of or within RNA processing and adenosine to inosine editing. Predicted to be located in cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See adar.S in Genome Data Viewer
    Location:
    chromosome: 8S
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (101834783..101855681, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (96825914..96847067, complement)

    Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene interleukin 6 receptor S homeolog Neighboring gene cholinergic receptor nicotinic beta 2 subunit S homeolog Neighboring gene uncharacterized LOC121397598 Neighboring gene potassium calcium-activated channel subfamily N member 3 S homeolog Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Xenopus dsRNA adenosine deaminase cDNAs reveals similarities to DNA methyltransferases. Hough RF, et al. RNA, 1997 Apr. PMID 9085843, Free PMC Article
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adenosine to inosine editing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase, RNA-specific S homeolog
    Names
    dsRNA adenosine deaminase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088206.1 → NP_001081675.1  adenosine deaminase, RNA-specific S homeolog

      See identical proteins and their annotated locations for NP_001081675.1

      Status: PROVISIONAL

      Source sequence(s)
      U88065
      UniProtKB/TrEMBL
      B7ZR43, O12982
      Conserved Domains (4) summary
      smart00550
      Location:257 → 324
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00358
      Location:680 → 745
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:885 → 1267
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      smart01104
      Location:53 → 180
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      101834783..101855681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018231900.2 → XP_018087389.1  adenosine deaminase, RNA-specific S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J0TME4, B7ZR43
      Related
      ENSXLAP00005093689.1, ENSXLAT00005095389.1
      Conserved Domains (5) summary
      smart00550
      Location:279 → 346
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:907 → 1289
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      PHA03247
      Location:17 → 283
      PHA03247; large tegument protein UL36; Provisional
      cd19914
      Location:700 → 770
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cl00054
      Location:817 → 887
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    2. XM_041574127.1 → XP_041430061.1  adenosine deaminase, RNA-specific S homeolog isoform X2

      UniProtKB/TrEMBL
      A0A1L8F4Z0, A0A974H6H5, B7ZR43
      Conserved Domains (5) summary
      smart00550
      Location:279 → 346
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:906 → 1288
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      PHA03247
      Location:17 → 283
      PHA03247; large tegument protein UL36; Provisional
      cd19914
      Location:699 → 769
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cl00054
      Location:816 → 886
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

    3. XM_041574126.1 → XP_041430060.1  adenosine deaminase, RNA-specific S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J0TME4, B7ZR43
      Related
      ENSXLAP00005093594.1, ENSXLAT00005095289.1
      Conserved Domains (5) summary
      smart00550
      Location:279 → 346
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:907 → 1289
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      PHA03247
      Location:17 → 283
      PHA03247; large tegument protein UL36; Provisional
      cd19914
      Location:700 → 770
      DSRM_DRADA_rpt2; second double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
      cl00054
      Location:817 → 887
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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