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    parn.S poly(A)-specific ribonuclease S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 108703108, updated on 4-Nov-2024

    Summary

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    Official Symbol
    parn.S
    Official Full Name
    poly(A)-specific ribonuclease S homeolog
    Primary source
    Xenbase:XB-GENE-17341054
    Locus tag
    XELAEV_18047495mg
    See related
    EnsemblRapid:ENSXLAG00005015037 AllianceGenome:Xenbase:XB-GENE-17341054
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    xparn
    Summary
    Predicted to enable RNA binding activity; metal ion binding activity; and poly(A)-specific ribonuclease activity. Predicted to act upstream of or within nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 6. Orthologous to human PARN (poly(A)-specific ribonuclease). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See parn.S in Genome Data Viewer
    Location:
    chromosome: 9_10S
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 9_10S NC_054388.1 (86837078..86911320)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 9_10S NC_030741.1 (80155105..80229560)

    Chromosome 9_10S - NC_054388.1Genomic Context describing neighboring genes Neighboring gene N-acetylgalactosaminidase, alpha- S homeolog Neighboring gene phospholipase A2 Neighboring gene uncharacterized LOC121398864 Neighboring gene transfer RNA threonine (anticodon CGU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(A)-specific ribonuclease PARN-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      86837078..86911320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041579290.1 → XP_041435224.1  poly(A)-specific ribonuclease PARN-like isoform X5

      UniProtKB/TrEMBL
      A0A8J1M0K6
      Conserved Domains (1) summary
      cd02637
      Location:181 → 245
      R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H ...

    2. XM_041579287.1 → XP_041435221.1  poly(A)-specific ribonuclease PARN-like isoform X2

      UniProtKB/Swiss-Prot
      Q6GN38, Q6NTN9, Q90ZA1
      UniProtKB/TrEMBL
      A0A8J1M1M4, A0A974H3X8
      Conserved Domains (1) summary
      cd02637
      Location:181 → 244
      R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H ...

    3. XM_041579289.1 → XP_041435223.1  poly(A)-specific ribonuclease PARN-like isoform X4

      UniProtKB/Swiss-Prot
      Q6GN38, Q6NTN9, Q90ZA1
      UniProtKB/TrEMBL
      A0A8J1M0F6, A0A974H3X8
      Related
      ENSXLAP00005044129.1, ENSXLAT00005045201.1
      Conserved Domains (1) summary
      cd02637
      Location:145 → 209
      R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H ...

    4. XM_041579288.1 → XP_041435222.1  poly(A)-specific ribonuclease PARN-like isoform X3

      UniProtKB/Swiss-Prot
      Q6GN38, Q6NTN9, Q90ZA1
      UniProtKB/TrEMBL
      A0A8J1M0H7, A0A974H3X8
      Related
      ENSXLAP00005044119.1, ENSXLAT00005045191.1
      Conserved Domains (1) summary
      cd02637
      Location:181 → 245
      R3H_PARN; R3H domain of Poly(A)-specific ribonuclease (PARN). PARN is a poly(A)-specific 3' exonuclease from the RNase D family that, in Xenopus, deadenylates a specific class of maternal mRNAs which results in their translational repression. The name of the R3H ...

    5. XM_018239091.2 → XP_018094580.1  poly(A)-specific ribonuclease PARN-like isoform X1

      UniProtKB/Swiss-Prot
      Q6GN38, Q6NTN9, Q90ZA1
      UniProtKB/TrEMBL
      A0A1L8EQ87, A0A974BVZ2, A0A974H3X8
      Related
      ENSXLAP00005044140.1, ENSXLAT00005045212.1
    Nucleotide Protein Strain
    Heading Accession and Version

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