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    PRSS41 serine protease 41 [ Homo sapiens (human) ]

    Gene ID: 360226, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PRSS41provided by HGNC
    Official Full Name
    serine protease 41provided by HGNC
    Primary source
    HGNC:HGNC:30715
    See related
    Ensembl:ENSG00000215148 AllianceGenome:HGNC:30715
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TESSP1
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See PRSS41 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2798470..2805304)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2819044..2825877)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2848471..2855305)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene serine protease 33 Neighboring gene small nucleolar RNA, H/ACA box 3C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2852262-2853224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2861337-2862067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2862068-2862797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2864940-2865440 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870033-2870534 Neighboring gene serine protease 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2870535-2871034 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
    2. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Ito T, et al. Nat Genet, 2021 Dec. PMID 34857952
    3. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Bagci H, et al. Nat Cell Biol, 2020 Jan. PMID 31871319
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 41
    Names
    protease, serine 41
    putative serine protease 41
    testis-specific serine protease 1
    NP_001341515.2
    NP_001382429.1
    NP_001382430.1
    NP_001382431.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354586.3 → NP_001341515.2  serine protease 41 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC092117, BN000124
      UniProtKB/Swiss-Prot
      Q7RTY9
      Conserved Domains (1) summary
      cd00190
      Location:55 → 295
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001395500.1 → NP_001382429.1  serine protease 41 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC092117
      Consensus CDS
      CCDS92091.1
      UniProtKB/TrEMBL
      A0A6I8PU99
      Related
      ENSP00000501492.1, ENST00000674256.1
      Conserved Domains (1) summary
      cd00190
      Location:71 → 311
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_001395501.1 → NP_001382430.1  serine protease 41 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC092117
      Consensus CDS
      CCDS92090.1
      UniProtKB/TrEMBL
      A0A6Q8NYF4
      Related
      ENSP00000492058.2, ENST00000399677.5
      Conserved Domains (1) summary
      cd00190
      Location:42 → 282
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. NM_001395502.1 → NP_001382431.1  serine protease 41 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC092117
      Conserved Domains (1) summary
      cd00190
      Location:42 → 181
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2798470..2805304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2819044..2825877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7RTY9.1 GenPept UniProtKB/Swiss-Prot:Q7RTY9

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    Chemical Information
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    Research Materials