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    PCLO piccolo presynaptic cytomatrix protein [ Sceloporus undulatus (fence lizard) ]

    Gene ID: 121931446, updated on 22-Mar-2024

    Summary

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    Gene symbol
    PCLO
    Gene description
    piccolo presynaptic cytomatrix protein
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sceloporus undulatus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Iguania; Phrynosomatidae; Phrynosomatinae; Sceloporus
    Orthologs
    human mouse all
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    Genomic context

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    See PCLO in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    100 current SceUnd_v1.1 (GCF_019175285.1) 5 NC_056526.1 (107327140..107620680, complement)

    Chromosome 5 - NC_056526.1Genomic Context describing neighboring genes Neighboring gene poly(U)-specific endoribonuclease-A-like Neighboring gene alpha 1,4-galactosyltransferase (P1PK blood group) Neighboring gene U2 spliceosomal RNA Neighboring gene semaphorin 3E Neighboring gene semaphorin 3A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056526.1 Chromosome 5 Reference SceUnd_v1.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in presynaptic active zone assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton of presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein piccolo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sceloporus undulatus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference SceUnd_v1.1

    Genomic

    1. NC_056526.1 Reference SceUnd_v1.1

      Range
      107327140..107620680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_042469225.1 → XP_042325159.1  protein piccolo isoform X4

      Conserved Domains (7) summary
      PTZ00121
      Location:989 → 1732
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4793 → 4927
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:23 → 433
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4598 → 4687
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:430 → 491
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:902 → 965
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5112 → 5237
      C2; C2 domain

    2. XM_042469224.1 → XP_042325158.1  protein piccolo isoform X3

      Conserved Domains (7) summary
      PTZ00121
      Location:989 → 1732
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4793 → 4927
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:23 → 433
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4598 → 4687
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:430 → 491
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:902 → 965
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5137 → 5262
      C2; C2 domain

    3. XM_042469223.1 → XP_042325157.1  protein piccolo isoform X2

      Conserved Domains (7) summary
      PTZ00121
      Location:989 → 1732
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4793 → 4927
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:23 → 433
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4598 → 4687
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:430 → 491
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:902 → 965
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5172 → 5297
      C2; C2 domain

    4. XM_042469221.1 → XP_042325155.1  protein piccolo isoform X1

      Conserved Domains (7) summary
      PTZ00121
      Location:989 → 1732
      PTZ00121; MAEBL; Provisional
      cd04031
      Location:4793 → 4927
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03247
      Location:23 → 433
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4598 → 4687
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:430 → 491
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:902 → 965
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
      cl14603
      Location:5173 → 5298
      C2; C2 domain

    5. XM_042469226.1 → XP_042325160.1  protein piccolo isoform X5

      Conserved Domains (5) summary
      PTZ00121
      Location:989 → 1732
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:23 → 433
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:4598 → 4684
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15774
      Location:430 → 491
      FYVE1_PCLO; FYVE-related domain 1 found in protein piccolo
      cd15776
      Location:902 → 965
      FYVE2_PCLO; FYVE-related domain 2 found in protein piccolo
    Nucleotide Protein
    Heading Accession and Version

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