Slc6a6 solute carrier family 6 member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc6a6provided by RGD
Official Full Name: solute carrier family 6 member 6provided by RGD
Primary source: RGD:61912
See related: EnsemblRapid:ENSRNOG00000009019 AllianceGenome:RGD:61912
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables gamma-aminobutyric acid:sodium:chloride symporter activity; taurine binding activity; and taurine:sodium symporter activity. Involved in gamma-aminobutyric acid import; import across plasma membrane; and taurine transmembrane transport. Located in dendrite; neuronal cell body; and plasma membrane. Part of plasma membrane protein complex. Orthologous to human SLC6A6 (solute carrier family 6 member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 304.5), Kidney (RPKM 299.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (125752340..125826033)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (124195186..124268880)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (123638619..123713469, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The purpose of this study was to clarify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na(+)-H(+) exchanger regulatory factor 1 as a regulatory mechanism of Slc6a6-mediated GABA transport activity
Title: Assembly of Taurine Transporter (Slc6a6) with Na(+)-H(+) Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity.
investigation of role of nitric oxide (NO) in regulation of functional activity of taurine transporter in renal brush border
Title: Functional impairment of rat taurine transporter by activation of nitrogen oxide through superoxide.
Glucose causes dysfunction of taurine uptake and downregulation of TAUT gene expression in cultured rat cardiomyocytes.
Title: [Hyperglycemia inhibited taurine transport and taurine transporter gene expression in cultured rat cardiomyocytes].
TauT (along with system A) plays a cytoprotective role in stressed syncytiotrophoblasts. TauT-knockdown using siRNA revealed that TauT is a major contributor to taurine uptake by TR-TBT 18d-1 cells under normal conditions.
Title: Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress.
prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation
Title: Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation.
[(14)C]guanidinoacetate was taken up by brain parenchymal cells in a concentrative manner most likely via taurine transporter and creatine transporter
Title: The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters.
SNAT2 expression is constitutively low in neurons under physiological conditions but potently induced, together with the taurine transporter TauT, in response to depletion of neutral amino acids
Title: SNAT2 amino acid transporter is regulated by amino acids of the SLC6 gamma-aminobutyric acid transporter subfamily in neocortical neurons and may play no role in delivering glutamine for glutamatergic transmission.
Data suggest that rat Slc6a6/TauT has the ability to use GABA as a substrate and Slc6a6/TauT-mediated GABA transport appears to be present at the inner blood-retinal barrier.
Title: Function of taurine transporter (Slc6a6/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells.
study demonstrates the transcription and translation of the taurine transporter in culture of vascular smooth muscle cells in vitro
Title: Taurine transporter is expressed in vascular smooth muscle cells.
Data demonstrate that rat hippocampal neurons express the taurine transporter.
Title: Taurine transporter regulation in hippocampal neurons.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

d4arb22 (e-PCR)
- UniSTS:121908

D4Wox56 (e-PCR)
- UniSTS:518967

AW531182 (e-PCR)
- UniSTS:245086

RH138809 (e-PCR)
- UniSTS:220896

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alanine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables amino acid:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables beta-alanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables gamma-aminobutyric acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables gamma-aminobutyric acid:sodium:chloride symporter activity	IEA Inferred from Electronic Annotation more info
enables gamma-aminobutyric acid:sodium:chloride symporter activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables taurine binding	IDA Inferred from Direct Assay more info	PubMed
enables taurine:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables taurine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables taurine:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables taurine:sodium symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alanine transport	IEA Inferred from Electronic Annotation more info
involved_in alanine transport	ISO Inferred from Sequence Orthology more info
involved_in amino acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in amino acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in amino acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within beta-alanine transport	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid import	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid import	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gamma-aminobutyric acid transport	IEA Inferred from Electronic Annotation more info
involved_in import across plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of nitrogen compound transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in taurine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in taurine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in taurine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in taurine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within taurine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in taurine transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	IPI Inferred from Physical Interaction more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium- and chloride-dependent taurine transporter

Names: Solute carrier 6 ,member 6 (taurine transporter); solute carrier family 6 (neurotransmitter transporter), member 6; solute carrier family 6 (neurotransmitter transporter, taurine), member 6; taurine/beta-alanine transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017206.2 → NP_058902.1 sodium- and chloride-dependent taurine transporter

See identical proteins and their annotated locations for NP_058902.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P31643

UniProtKB/TrEMBL

A0A0G2K227, A6IBA4

Related

ENSRNOP00000072080.2, ENSRNOT00000086982.3

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

125752340..125826033

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008763123.4 → XP_008761345.1 sodium- and chloride-dependent taurine transporter isoform X1

UniProtKB/TrEMBL

A0A0G2K227, A0A8I6AL67

Related

ENSRNOP00000012875.5, ENSRNOT00000012875.8

Conserved Domains (1) summary

cl00456
Location:51 → 592

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063285685.1 → XP_063141755.1 sodium- and chloride-dependent taurine transporter isoform X1

UniProtKB/TrEMBL

A0A8I6AL67
XM_039107210.2 → XP_038963138.1 sodium- and chloride-dependent taurine transporter isoform X3

Conserved Domains (1) summary

cl00456
Location:51 → 342

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_006236903.5 → XP_006236965.1 sodium- and chloride-dependent taurine transporter isoform X2

See identical proteins and their annotated locations for XP_006236965.1

UniProtKB/Swiss-Prot

P31643

UniProtKB/TrEMBL

A0A0G2K227, A6IBA4

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063285684.1 → XP_063141754.1 sodium- and chloride-dependent taurine transporter isoform X1

UniProtKB/TrEMBL

A0A8I6AL67
XM_039107207.2 → XP_038963135.1 sodium- and chloride-dependent taurine transporter isoform X1

UniProtKB/TrEMBL

A0A0G2K227, A0A8I6AL67

Conserved Domains (1) summary

cl00456
Location:51 → 592

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063285683.1 → XP_063141753.1 sodium- and chloride-dependent taurine transporter isoform X1

UniProtKB/TrEMBL

A0A8I6AL67
XM_039107206.2 → XP_038963134.1 sodium- and chloride-dependent taurine transporter isoform X1

UniProtKB/TrEMBL

A0A0G2K227, A0A8I6AL67

Conserved Domains (1) summary

cl00456
Location:51 → 592

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_039107208.2 → XP_038963136.1 sodium- and chloride-dependent taurine transporter isoform X2

UniProtKB/Swiss-Prot

P31643

UniProtKB/TrEMBL

A0A0G2K227, A6IBA4

Conserved Domains (1) summary

cl00456
Location:41 → 582

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
XM_063285686.1 → XP_063141756.1 sodium- and chloride-dependent taurine transporter isoform X4