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    TSHR thyroid stimulating hormone receptor [ Gallus gallus (chicken) ]

    Gene ID: 428900, updated on 10-Oct-2024

    Summary

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    Symbol
    TSHRprovided by CGNC
    Full Name
    thyroid stimulating hormone receptorprovided by CGNC
    Primary source
    CGNC:8028
    See related
    Ensembl:ENSGALG00010004364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TSHR in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (40273166..40325248)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (40250773..40302841)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110832 Neighboring gene centrosomal protein 128 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene general transcription factor IIA subunit 1 Neighboring gene uncharacterized LOC121111039 Neighboring gene uncharacterized LOC121111041 Neighboring gene stonin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and dynamic analysis of G558R mutation in chicken TSHR gene shows altered signal transduction and corroborates its role as a domestication gene. Grottesi A, et al. Anim Genet, 2020 Feb. PMID 31746479
    2. A domestication related mutation in the thyroid stimulating hormone receptor gene (TSHR) modulates photoperiodic response and reproduction in chickens. Karlsson AC, et al. Gen Comp Endocrinol, 2016 Mar 1. PMID 26873630
    3. Whole-genome resequencing reveals loci under selection during chicken domestication. Rubin CJ, et al. Nature, 2010 Mar 25. PMID 20220755
    4. Chicken folliculo-stellate cells express thyrotropin receptor mRNA. Grommen SV, et al. Domest Anim Endocrinol, 2009 Nov. PMID 19683409
    5. Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: the chicken TSHR gene revisited. Grommen SV, et al. Gen Comp Endocrinol, 2008 May 1. PMID 18400223

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the G558R mutation in chicken TSHR gene shows altered signal transduction and is a domestication gene
      Title: Structural and dynamic analysis of G558R mutation in chicken TSHR gene shows altered signal transduction and corroborates its role as a domestication gene.
    2. A domestication related mutation in the thyroid stimulating hormone receptor gene modulates photoperiodic response and reproduction in chickens.
      Title: A domestication related mutation in the thyroid stimulating hormone receptor gene (TSHR) modulates photoperiodic response and reproduction in chickens.
    3. In the pituitary gland, TSHR mRNA co-localizes with folliculo-stellate cells but not with thyrotropic cells. TSHR mRNA was also present throughout the diencephalon and various other brain regions.
      Title: Chicken folliculo-stellate cells express thyrotropin receptor mRNA.
    4. TSHRb, -d, -e and -f mRNA was also present in virtually all extra-thyroidal tissues expressing TSHRa, whereas TSHRc shows a more restricted tissue distribution
      Title: Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: the chicken TSHR gene revisited.
    5. cloning & characterization of TSHR, a G protein-coupled receptor consisting of 10 exons; TSHR mRNA was found in thyroidal follicular cells & other tissues; relative expression of thyroidal TSHR mRNA did not change in the last week of embryonic development
      Title: Molecular cloning, tissue distribution, and ontogenic thyroidal expression of the chicken thyrotropin receptor.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables thyroid-stimulating hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyrotropin receptor
    Names
    thyroid stimulating hormone receptor variant truncated type 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033850.2 → NP_001029022.2  thyrotropin receptor isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region compared to variant 1. Isoform 3 is shorter compared to isoform 3.
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XMD3
      Related
      ENSGALP00010005958.1, ENSGALT00010010196.1

    2. NM_001193588.3 → NP_001180517.2  thyrotropin receptor isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      Q3V5M1
      Conserved Domains (2) summary
      sd00033
      Location:76 → 100
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:414 → 688
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001193589.3 → NP_001180518.2  thyrotropin receptor isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. Isoform 2 is shorter compared to isoform 1.
      Source sequence(s)
      JAENSK010000215
      UniProtKB/TrEMBL
      A0A8V0XP56, Q3V5M0
      Related
      ENSGALP00010005971.1, ENSGALT00010010212.1
      Conserved Domains (2) summary
      sd00033
      Location:76 → 100
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:389 → 663
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      40273166..40325248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025150837.3 → XP_025006605.2  thyrotropin receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XJM6, D5JGF9
      Related
      ENSGALP00010005977.1, ENSGALT00010010220.1
      Conserved Domains (2) summary
      sd00033
      Location:45 → 69
      LRR_RI; leucine-rich repeat [structural motif]
      cd15964
      Location:383 → 657
      7tmA_TSH-R; thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      40250773..40302841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046918866.1 → XP_046774822.1  thyrotropin receptor isoform X1

      UniProtKB/TrEMBL
      A0A8V0XJM6
    Nucleotide Protein Strain
    Heading Accession and Version

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