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    Noc3 Nucleolar complex protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40870, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Noc3provided by FlyBase
    Official Full Name
    Nucleolar complex protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037489
    Locus tag
    Dmel_CG1234
    See related
    AllianceGenome:FB:FBgn0037489
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1234; Dmel\CG1234; NOC3
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in DNA replication initiation. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; embryonic Malpighian tubule; embryonic/larval muscle system; extended germ band embryo; and gut section. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Noc3 in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7244232..7246969, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3069954..3072691, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene thawb Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduction of nucleolar NOC1 leads to the accumulation of pre-rRNAs and induces Xrp1, affecting growth and resulting in cell competition. Destefanis F, et al. J Cell Sci, 2022 Dec 1. PMID 36314272, Free PMC Article
    2. Drosophila Myc interacts with host cell factor (dHCF) to activate transcription and control growth. Furrer M, et al. J Biol Chem, 2010 Dec 17. PMID 20937797, Free PMC Article
    3. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Somma MP, et al. PLoS Genet, 2008 Jul 18. PMID 18797514, Free PMC Article
    4. An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. Vinayagam A, et al. Cell Rep, 2016 Sep 13. PMID 27626673, Free PMC Article
    5. Transcription factor networks in Drosophila melanogaster. Rhee DY, et al. Cell Rep, 2014 Sep 25. PMID 25242320, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc2p-Noc3p complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar complex protein 3
    Names
    CG1234-PA
    Noc3-PA
    nucleolar complex protein-3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7244232..7246969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141453.5 → NP_649710.1  nucleolar complex protein 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649710.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VI82
      Related
      FBpp0081117
      Conserved Domains (3) summary
      COG5117
      Location:228 → 727
      NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
      pfam03914
      Location:574 → 727
      CBF; CBF/Mak21 family
      pfam07540
      Location:235 → 330
      NOC3p; Nucleolar complex-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI82.1 Q9VI82

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