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    ZNF860 zinc finger protein 860 [ Homo sapiens (human) ]

    Gene ID: 344787, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF860provided by HGNC
    Official Full Name
    zinc finger protein 860provided by HGNC
    Primary source
    HGNC:HGNC:34513
    See related
    Ensembl:ENSG00000197385 AllianceGenome:HGNC:34513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lymph node (RPKM 1.1), prostate (RPKM 0.9) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF860 in Genome Data Viewer
    Location:
    3p23-p22.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (31981750..32006443)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (31984716..32009928)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32023242..32033215)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 10 Neighboring gene OSBPL10 antisense RNA 1 Neighboring gene zinc finger protein 587 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:31938297-31938798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:31987818-31988420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:31988421-31989022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14164 Neighboring gene small nucleolar RNA SNORA25 Neighboring gene ribosomal protein L21 pseudogene 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Bioinformatic analysis of the prognostic value of ZNF860 in recurrence-free survival and its potential regulative network in gastric cancer. Pan HX, et al. Eur Rev Med Pharmacol Sci, 2019 Jan. PMID 30767193
    2. Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years. Shaffer JR, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347629, Free PMC Article
    3. The DNA sequence, annotation and analysis of human chromosome 3. Muzny DM, et al. Nature, 2006 Apr 27. PMID 16641997
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ60236

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 860

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001137674.3 → NP_001131146.2  zinc finger protein 860

      See identical proteins and their annotated locations for NP_001131146.2

      Status: VALIDATED

      Source sequence(s)
      AC108485, AK294003, BQ268755
      Consensus CDS
      CCDS46784.1
      UniProtKB/Swiss-Prot
      A6NHJ4, B4DFA4
      Related
      ENSP00000373274.3, ENST00000360311.5
      Conserved Domains (5) summary
      smart00349
      Location:24 → 64
      KRAB; krueppel associated box
      COG5048
      Location:284 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:288 → 308
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:24 → 63
      KRAB; KRAB box
      pfam13465
      Location:328 → 353
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      31981750..32006443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448072.1 → XP_047304028.1  zinc finger protein 860 isoform X1

      UniProtKB/Swiss-Prot
      A6NHJ4, B4DFA4

    2. XM_047448074.1 → XP_047304030.1  zinc finger protein 860 isoform X1

      UniProtKB/Swiss-Prot
      A6NHJ4, B4DFA4

    3. XM_047448073.1 → XP_047304029.1  zinc finger protein 860 isoform X1

      UniProtKB/Swiss-Prot
      A6NHJ4, B4DFA4

    RNA

    1. XR_001740138.2 RNA Sequence

    2. XR_007095674.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      31984716..32009928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346427.1 → XP_054202402.1  zinc finger protein 860 isoform X1

      UniProtKB/Swiss-Prot
      A6NHJ4, B4DFA4

    2. XM_054346429.1 → XP_054202404.1  zinc finger protein 860 isoform X1

      UniProtKB/Swiss-Prot
      A6NHJ4, B4DFA4

    3. XM_054346428.1 → XP_054202403.1  zinc finger protein 860 isoform X1

      UniProtKB/Swiss-Prot
      A6NHJ4, B4DFA4

    RNA

    1. XR_007073404.1 RNA Sequence

    2. XR_007073405.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NHJ4.3 GenPept UniProtKB/Swiss-Prot:A6NHJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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