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    PGA4 pepsinogen A4 [ Homo sapiens (human) ]

    Gene ID: 643847, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PGA4provided by HGNC
    Official Full Name
    pepsinogen A4provided by HGNC
    Primary source
    HGNC:HGNC:8886
    See related
    Ensembl:ENSG00000229183 MIM:169720; AllianceGenome:HGNC:8886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
    Expression
    Restricted expression toward stomach (RPKM 23688.7) See more
    Orthologs
    all
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    Genomic context

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    See PGA4 in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61222347..61231694)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61211336..61220690)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60989819..60999166)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60960971-60961472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:60961473-60961972 Neighboring gene pepsinogen A3 Neighboring gene pepsinogen A5 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:61033788-61034987 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61048939-61049860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3387 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61061839-61062541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human pepsin and its complex with pepstatin. Fujinaga M, et al. Protein Sci, 1995 May. PMID 7663352, Free PMC Article
    2. Activation of human pepsinogens. Foltmann B. FEBS Lett, 1988 Dec 5. PMID 3197840
    3. Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family. Evers MP, et al. Genomics, 1989 Apr. PMID 2714789
    4. Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A. Kageyama T, et al. J Biochem, 1980 Aug. PMID 6774973
    5. Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping. Hynek R, et al. J Chromatogr B Biomed Sci Appl, 1997 Jan 24. PMID 9061458

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ58952, FLJ77962

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in multivesicular body lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    pepsin A-4
    Names
    pepsinogen 4, group I (pepsinogen A)
    pepsinogen-4
    pregnancy-associated glycoprotein
    NP_001073276.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079808.6 → NP_001073276.1  pepsin A-4 preproprotein

      See identical proteins and their annotated locations for NP_001073276.1

      Status: REVIEWED

      Source sequence(s)
      AP000437, AP003037
      Consensus CDS
      CCDS31575.1
      UniProtKB/Swiss-Prot
      P0DJD7
      UniProtKB/TrEMBL
      A0A1S5UZ02, B7ZW16
      Related
      ENSP00000367391.3, ENST00000378149.9
      Conserved Domains (2) summary
      cd05478
      Location:66 → 386
      pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
      pfam07966
      Location:17 → 45
      A1_Propeptide; A1 Propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      61222347..61231694
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      61211336..61220690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DJD7.1 GenPept UniProtKB/Swiss-Prot:P0DJD7

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