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    ZNF706 zinc finger protein 706 [ Homo sapiens (human) ]

    Gene ID: 51123, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF706provided by HGNC
    Official Full Name
    zinc finger protein 706provided by HGNC
    Primary source
    HGNC:HGNC:24992
    See related
    Ensembl:ENSG00000120963 MIM:619526; AllianceGenome:HGNC:24992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPC038; PNAS-106; PNAS-113
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of stem cell population maintenance. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 17.8), skin (RPKM 13.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF706 in Genome Data Viewer
    Location:
    8q22.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (101197052..101206222, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (102322770..102331941, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (102209280..102218450, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375676 Neighboring gene NFE2L2 motif-containing MPRA enhancer 220/221 Neighboring gene Sharpr-MPRA regulatory region 12327 Neighboring gene Sharpr-MPRA regulatory region 12099 Neighboring gene Sharpr-MPRA regulatory region 1163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27728 Neighboring gene ZNF706 neighboring transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19432 Neighboring gene uncharacterized LOC107984005 Neighboring gene Sharpr-MPRA regulatory region 4487 Neighboring gene myeloid leukemia factor 2 pseudogene Neighboring gene MPRA-validated peak7131 silencer Neighboring gene long intergenic non-protein coding RNA 2844

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation. Sahoo BR, et al. Nucleic Acids Res, 2024 May 8. PMID 38572746, Free PMC Article
    2. The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume. Dossena S, et al. J Biol Chem, 2011 Nov 25. PMID 21917931, Free PMC Article
    3. A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma. Chu J, et al. Cell Death Differ, 2024 Oct. PMID 38862581, Free PMC Article
    4. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. McClay JL, et al. Neuropsychopharmacology, 2011 Feb. PMID 21107309, Free PMC Article
    5. Splicing Regulator p54(nrb) /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hu Z, et al. Hepatology, 2020 Aug. PMID 31815296

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma.
      Title: A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma.
    2. Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation.
      Title: Protein G-quadruplex interactions and their effects on phase transitions and protein aggregation.
    3. functional interaction between ICln and HSPC038
      Title: The molecular and functional interaction between ICln and HSPC038 proteins modulates the regulation of cell volume.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 706

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042510.2 → NP_001035975.1  zinc finger protein 706

      See identical proteins and their annotated locations for NP_001035975.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AP001330, AP003469
      Consensus CDS
      CCDS6291.1
      UniProtKB/Swiss-Prot
      A8K362, Q9Y5V0
      UniProtKB/TrEMBL
      Q9HB72
      Related
      ENSP00000428985.1, ENST00000519882.5
      Conserved Domains (1) summary
      pfam18658
      Location:41 → 65
      zf-C2H2_12; Zinc-finger C2H2-type

    2. NM_001267708.2 → NP_001254637.1  zinc finger protein 706

      See identical proteins and their annotated locations for NP_001254637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AP001330, AP003469
      Consensus CDS
      CCDS6291.1
      UniProtKB/Swiss-Prot
      A8K362, Q9Y5V0
      UniProtKB/TrEMBL
      Q9HB72
      Related
      ENSP00000430165.1, ENST00000521272.5
      Conserved Domains (1) summary
      pfam18658
      Location:41 → 65
      zf-C2H2_12; Zinc-finger C2H2-type

    3. NM_001267709.2 → NP_001254638.1  zinc finger protein 706

      See identical proteins and their annotated locations for NP_001254638.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AP001330, AP003469
      Consensus CDS
      CCDS6291.1
      UniProtKB/Swiss-Prot
      A8K362, Q9Y5V0
      UniProtKB/TrEMBL
      Q9HB72
      Related
      ENSP00000428696.1, ENST00000518336.5
      Conserved Domains (1) summary
      pfam18658
      Location:41 → 65
      zf-C2H2_12; Zinc-finger C2H2-type

    4. NM_016096.5 → NP_057180.1  zinc finger protein 706

      See identical proteins and their annotated locations for NP_057180.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein.
      Source sequence(s)
      AP001330, AP003469
      Consensus CDS
      CCDS6291.1
      UniProtKB/Swiss-Prot
      A8K362, Q9Y5V0
      UniProtKB/TrEMBL
      Q9HB72
      Related
      ENSP00000311768.4, ENST00000311212.9
      Conserved Domains (1) summary
      pfam18658
      Location:41 → 65
      zf-C2H2_12; Zinc-finger C2H2-type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      101197052..101206222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421844.1 → XP_047277800.1  zinc finger protein 706 isoform X1

      UniProtKB/Swiss-Prot
      A8K362, Q9Y5V0
      Related
      ENSP00000428227.1, ENST00000517844.5

    2. XM_047421843.1 → XP_047277799.1  zinc finger protein 706 isoform X1

      UniProtKB/Swiss-Prot
      A8K362, Q9Y5V0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      102322770..102331941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360612.1 → XP_054216587.1  zinc finger protein 706 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y5V0.1 GenPept UniProtKB/Swiss-Prot:Q9Y5V0

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