RT1-A RT1 class I, locus A [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: RT1-Aprovided by RGD
Official Full Name: RT1 class I, locus Aprovided by RGD
Primary source: RGD:2300147
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RTA; Rt1.aa
Annotation information: not in current annotation release
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Genomic context

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Location:: chromosome: 20

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a simultaneous increase in the portion of cells that express the RT1A antigen and in the level of its expression per cell was observed
Title: [Expression of the RT1A molecule of the class I major histocompatibility complex in a Walker 256 tumor after transplantation into Brattleboro rats with a genetic defect of arginine-vasopressin synthesis].
Data show that allochimeric Rt1 treatment caused upregulation of genes involved in structural integrity of heart muscle, downregulation of IL-1b and gamma PAR6.
Title: Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model.
Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B
Title: Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B.

Submit: New GeneRIF Correction

General gene information

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Markers

H2-K1 (e-PCR), detects polymorphism
- UniSTS:463411

BI280335 (e-PCR)
- UniSTS:249032

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
part_of MHC class I protein complex	IEA Inferred from Electronic Annotation more info
located_in lumenal side of endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RT1 class I histocompatibility antigen, AA alpha chain

Names: MHC class I RT1.Aa alpha-chain; RT1 class I gene(A); RT1-region, class I (A)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134701.1 → NP_001128173.1 RT1 class I histocompatibility antigen, AA alpha chain precursor

See identical proteins and their annotated locations for NP_001128173.1

Status: PROVISIONAL

Source sequence(s)

BC166751

UniProtKB/Swiss-Prot

O02940, P16391

UniProtKB/TrEMBL

B2RYE7

Conserved Domains (3) summary

cd07698
Location:207 → 299

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

pfam00129
Location:25 → 203

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

pfam06623
Location:343 → 369

MHC_I_C; MHC_I C-terminus