STRN3 striatin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STRN3provided by HGNC
Official Full Name: striatin 3provided by HGNC
Primary source: HGNC:HGNC:15720
See related: Ensembl:ENSG00000196792 MIM:614766; AllianceGenome:HGNC:15720
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SG2NA; S/G2NA; PPP2R6B
Summary: Enables armadillo repeat domain binding activity; enzyme binding activity; and protein-macromolecule adaptor activity. Involved in negative regulation of hippo signaling; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; nucleoplasm; and plasma membrane. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis (RPKM 11.4), fat (RPKM 8.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (30893804..31026379, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (25091284..25224212, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (31363010..31495585, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway.
Title: STRN3 promotes tumour growth in hepatocellular carcinoma by inhibiting the hippo pathway.
Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.
Title: Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.
The profile of expression of the scaffold protein SG2NA(s) differs between cancer types and its interactome in normal vis-a-vis breast tumor tissues suggests its wide roles in regulating multiple cellular pathways.
Title: The profile of expression of the scaffold protein SG2NA(s) differs between cancer types and its interactome in normal vis-a-vis breast tumor tissues suggests its wide roles in regulating multiple cellular pathways.
Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.
Title: Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.
we detected novel and related STRN-NTRK3 and STRN3-NTRK3 fusions in 2 fibrosarcomas that occurred in the bone and soft tissue of young adult patients
Title: Novel NTRK3 Fusions in Fibrosarcomas of Adults.
this study propose that the STRIPAK complex, FAM40A, FAM40B and STRN3, regulates the mode of cancer cell migration by controlling the activity of MST3 and 4, which locally coordinate the phosphorylation of ERM proteins and inhibit the dephosphorylation of MLC leading to increased actin-membrane linkage.
Title: STRIPAK components determine mode of cancer cell migration and metastasis.
results demonstrate that XBP1 mRNA splicing plays an important role in maintaining the function of bone marrow-derived macrophages and provide new insight into the study and treatment of atherosclerosis
Title: SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt.
The structure and protein-binding domains of the SG2NA protein variants have been described.
Title: Molecular modeling and molecular dynamics simulations based structural analysis of the SG2NA protein variants.
This result combined with a number of biophysical analyses provide evidence that the coiled coil domain of striatin 3 and the PP2A A subunit form a stable core complex with a 2:2 stoichiometry
Title: Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex.
STRN3 (rs2273171)is associated with single nucleotide polymorphisms in Korean patients, either non-segmental or segmental type.
Title: Three new single nucleotide polymorphisms identified by a genome-wide association study in Korean patients with vitiligo.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D14S569 (e-PCR)
- UniSTS:9242

SGC31556 (e-PCR)
- UniSTS:7709

NoName (e-PCR)
- UniSTS:236842

D14S558 (e-PCR)
- UniSTS:149346

SHGC-64093 (e-PCR)
- UniSTS:31108

G35940 (e-PCR)
- UniSTS:43655

G35594 (e-PCR)
- UniSTS:24456

D14S175 (e-PCR)
- UniSTS:148400

D14S176 (e-PCR)
- UniSTS:148401

RH64942 (e-PCR)
- UniSTS:89811

RH47070 (e-PCR)
- UniSTS:80365

SHGC-81030 (e-PCR)
- UniSTS:102644

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: striatin-3

Names: cell cycle S/G2 nuclear autoantigen; cell cycle autoantigen SG2NA; nuclear autoantigen; protein phosphatase 2 regulatory subunit B'''beta; s/G2 antigen; striatin, calmodulin binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083893.2 → NP_001077362.1 striatin-3 isoform 1

See identical proteins and their annotated locations for NP_001077362.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), also known as the beta isoform.

Source sequence(s)

AA572712, AF243424, AL049830, BC132673, DA854600

Consensus CDS

CCDS41938.1

UniProtKB/Swiss-Prot

A2RTX7, A6NHZ7, Q13033, Q9NRA5

UniProtKB/TrEMBL

A0AV58

Related

ENSP00000350071.5, ENST00000357479.10

Conserved Domains (4) summary

COG2319
Location:473 → 790

WD40; WD40 repeat [General function prediction only]

cd00200
Location:475 → 796

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 190

Striatin; Striatin family

sd00039
Location:485 → 531

7WD40; WD40 repeat [structural motif]
NM_014574.4 → NP_055389.3 striatin-3 isoform 2

See identical proteins and their annotated locations for NP_055389.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform 2, also known as the alpha isoform), compared to isoform 1.

Source sequence(s)

AA572712, AL049830, BC132673, DA854600

Consensus CDS

CCDS9641.1

UniProtKB/TrEMBL

A0AV58

Related

ENSP00000347909.5, ENST00000355683.9

Conserved Domains (3) summary

cd00200
Location:391 → 712

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:401 → 447

7WD40; WD40 repeat [structural motif]

pfam08232
Location:65 → 190

Striatin; Striatin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

30893804..31026379 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005267569.5 → XP_005267626.1 striatin-3 isoform X2

UniProtKB/TrEMBL

A0AV58

Conserved Domains (4) summary

COG2319
Location:436 → 753

WD40; WD40 repeat [General function prediction only]

cd00200
Location:438 → 759

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 190

Striatin; Striatin family

sd00039
Location:448 → 494

7WD40; WD40 repeat [structural motif]
XM_005267570.5 → XP_005267627.1 striatin-3 isoform X3

UniProtKB/TrEMBL

A0AV58

Conserved Domains (4) summary

COG2319
Location:426 → 743

WD40; WD40 repeat [General function prediction only]

cd00200
Location:428 → 749

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 190

Striatin; Striatin family

sd00039
Location:438 → 484

7WD40; WD40 repeat [structural motif]
XM_047431321.1 → XP_047287277.1 striatin-3 isoform X1