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    Tubal3 tubulin, alpha-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 238463, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tubal3provided by MGI
    Official Full Name
    tubulin, alpha-like 3provided by MGI
    Primary source
    MGI:MGI:3588215
    See related
    Ensembl:ENSMUSG00000021216 AllianceGenome:MGI:3588215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. Orthologous to human TUBAL3 (tubulin alpha like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 15.6), small intestine adult (RPKM 7.0) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tubal3 in Genome Data Viewer
    Location:
    13 A1; 13 2.19 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (3974695..3985277)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (3924654..3935277)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene calmodulin 5 Neighboring gene STARR-seq mESC enhancer starr_33494 Neighboring gene STARR-positive B cell enhancer ABC_E9391 Neighboring gene neuroepithelial cell transforming gene 1 Neighboring gene STARR-positive B cell enhancer ABC_E7198 Neighboring gene urocortin 3 Neighboring gene aldo-keto reductase family 1, member C13 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice. Pham AH, et al. Cells, 2024 May 8. PMID 38786026, Free PMC Article
    2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    5. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin alpha chain-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033879.3 → NP_001029051.2  tubulin alpha chain-like 3 isoform 1

      See identical proteins and their annotated locations for NP_001029051.2

      Status: VALIDATED

      Source sequence(s)
      AC139323, AK135971, CO796832
      Consensus CDS
      CCDS49202.1
      UniProtKB/Swiss-Prot
      B9EJS3, Q3UX10
      Related
      ENSMUSP00000021639.7, ENSMUST00000021639.8
      Conserved Domains (2) summary
      PTZ00335
      Location:1 → 443
      PTZ00335; tubulin alpha chain; Provisional
      cd02186
      Location:2 → 442
      alpha_tubulin; The alpha-tubulin family

    2. NM_001426388.1 → NP_001413317.1  tubulin alpha chain-like 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139323

    3. NM_001426389.1 → NP_001413318.1  tubulin alpha chain-like 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139323

    4. NM_001426391.1 → NP_001413320.1  tubulin alpha chain-like 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC139323

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      3974695..3985277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516479.3 → XP_006516542.1  tubulin alpha chain-like 3 isoform X1

      Conserved Domains (1) summary
      cd02186
      Location:12 → 322
      alpha_tubulin; The alpha-tubulin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UX10.2 GenPept UniProtKB/Swiss-Prot:Q3UX10

    Gene LinkOut

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