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    Sycn syncollin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245917, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sycnprovided by RGD
    Official Full Name
    syncollinprovided by RGD
    Primary source
    RGD:620862
    See related
    EnsemblRapid:ENSRNOG00000019879 AllianceGenome:RGD:620862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Syl
    Summary
    Predicted to be involved in regulation of calcium ion-dependent exocytosis. Predicted to be located in zymogen granule membrane. Orthologous to human SYCN (syncollin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Sycn in Genome Data Viewer
    Location:
    1q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (92950761..92961077)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (83823836..83833542)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (85219827..85220239, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene interferon, lambda 1 Neighboring gene interferon, lambda 3 Neighboring gene NCCRP1, F-box associated domain containing Neighboring gene p21 (RAC1) activated kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The secretory granule protein syncollin binds to syntaxin in a Ca2(+)-sensitive manner. Edwardson JM, et al. Cell, 1997 Jul 25. PMID 9244306
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion-dependent exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in zymogen granule membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    syncollin
    Names
    proximal small intestine-specific protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389242.1 → NP_001376171.1  syncollin precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O35775
      UniProtKB/TrEMBL
      A6J9J6
      Conserved Domains (1) summary
      pfam15138
      Location:22 → 133
      Syncollin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      92950761..92961077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097777.2 → XP_038953705.1  syncollin isoform X2

      UniProtKB/Swiss-Prot
      O35775
      UniProtKB/TrEMBL
      A6J9J6
      Conserved Domains (1) summary
      pfam15138
      Location:22 → 133
      Syncollin

    2. XM_063280797.1 → XP_063136867.1  syncollin isoform X2

      UniProtKB/Swiss-Prot
      O35775
      UniProtKB/TrEMBL
      A6J9J6

    3. XM_063280792.1 → XP_063136862.1  syncollin isoform X1

      Related
      ENSRNOP00000026907.4, ENSRNOT00000026907.7

    4. XM_039097703.2 → XP_038953631.1  syncollin isoform X2

      UniProtKB/Swiss-Prot
      O35775
      UniProtKB/TrEMBL
      A6J9J6
      Conserved Domains (1) summary
      pfam15138
      Location:22 → 133
      Syncollin

    5. XM_039097737.2 → XP_038953665.1  syncollin isoform X2

      UniProtKB/Swiss-Prot
      O35775
      UniProtKB/TrEMBL
      A6J9J6
      Conserved Domains (1) summary
      pfam15138
      Location:22 → 133
      Syncollin

    6. XM_063280799.1 → XP_063136869.1  syncollin isoform X2

      UniProtKB/Swiss-Prot
      O35775
      UniProtKB/TrEMBL
      A6J9J6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_139086.1: Suppressed sequence

      Description
      NM_139086.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35775.2 GenPept UniProtKB/Swiss-Prot:O35775

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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