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    UBC28 ubiquitin-conjugating enzyme 28 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842728, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBC28
    Official Full Name
    ubiquitin-conjugating enzyme 28
    Primary source
    TAIR:AT1G64230
    Locus tag
    AT1G64230
    See related
    Araport:AT1G64230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22C12.2; F22C12_2; ubiquitin-conjugating enzyme 28; UBIQUITIN-CONJUGATING ENZYME28
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    Genomic context

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    See UBC28 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (23833485..23835539)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene translocase of outer membrane 7 kDa subunit 2 Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis membrane-anchored ubiquitin-fold (MUB) proteins localize a specific subset of ubiquitin-conjugating (E2) enzymes to the plasma membrane. Dowil RT, et al. J Biol Chem, 2011 Apr 29. PMID 21345795, Free PMC Article
    2. Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis. Kraft E, et al. Plant Physiol, 2005 Dec. PMID 16339806, Free PMC Article
    3. Arabidopsis scaffold protein RACK1A interacts with diverse environmental stress and photosynthesis related proteins. Kundu N, et al. Plant Signal Behav, 2013 May. PMID 23435172, Free PMC Article
    4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036151.1
    NM_001160973.1
    NM_001160974.1
    NM_001198379.1
    NM_105097.9

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme 28
    NP_001031228.1
    • ubiquitin-conjugating enzyme 28 (UBC28); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin conjugating enzyme 8 (TAIR:AT5G41700.5); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001154445.1
    • ubiquitin-conjugating enzyme 28 (UBC28); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin conjugating enzyme 9 (TAIR:AT4G27960.1); Has 10537 Blast hits to 10496 proteins in 399 species: Archae - 0; Bacteria - 4; Metazoa - 4600; Fungi - 2215; Plants - 1971; Viruses - 26; Other Eukaryotes - 1721 (source: NCBI BLink).
    NP_001154446.1
    • ubiquitin-conjugating enzyme 28 (UBC28); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin conjugating enzyme 8 (TAIR:AT5G41700.5); Has 10460 Blast hits to 10419 proteins in 398 species: Archae - 0; Bacteria - 4; Metazoa - 4543; Fungi - 2213; Plants - 1965; Viruses - 26; Other Eukaryotes - 1709 (source: NCBI BLink).
    NP_001185308.1
    • ubiquitin-conjugating enzyme 28 (UBC28); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin conjugating enzyme 8 (TAIR:AT5G41700.5).
    NP_564828.1
    • ubiquitin-conjugating enzyme 28 (UBC28); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin conjugating enzyme 8 (TAIR:AT5G41700.5); Has 10654 Blast hits to 10613 proteins in 404 species: Archae - 0; Bacteria - 4; Metazoa - 4603; Fungi - 2343; Plants - 1945; Viruses - 27; Other Eukaryotes - 1732 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23833485..23835539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105097.9 → NP_564828.1  ubiquitin-conjugating enzyme 28 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94F47, Q9SH72
      UniProtKB/TrEMBL
      A0A178VAX4, A0A178WCS7, A0A5S9WRW9
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_001198379.1 → NP_001185308.1  ubiquitin-conjugating enzyme 28 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185308.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I5B8
      Conserved Domains (2) summary
      COG5078
      Location:1 → 189
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:1 → 188
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_001160973.1 → NP_001154445.1  ubiquitin-conjugating enzyme 28 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154445.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I5C0
      Conserved Domains (2) summary
      COG5078
      Location:1 → 156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:1 → 155
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_001160974.1 → NP_001154446.1  ubiquitin-conjugating enzyme 28 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I5B8
      Conserved Domains (2) summary
      COG5078
      Location:1 → 189
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cl00154
      Location:1 → 188
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    5. NM_001036151.1 → NP_001031228.1  ubiquitin-conjugating enzyme 28 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94F47, Q9SH72
      UniProtKB/TrEMBL
      A0A178VAX4, A0A178WCS7, A0A5S9WRW9
      Conserved Domains (1) summary
      cl00154
      Location:1 → 146
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94F47.1

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