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    CEACAM4 CEA cell adhesion molecule 4 [ Homo sapiens (human) ]

    Gene ID: 1089, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CEACAM4provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 4provided by HGNC
    Primary source
    HGNC:HGNC:1816
    See related
    Ensembl:ENSG00000105352 MIM:619159; AllianceGenome:HGNC:1816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCA; CGM7; CGM7_HUMAN
    Summary
    Predicted to enable protein tyrosine kinase binding activity. Involved in phagocytosis. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bone marrow (RPKM 8.4), spleen (RPKM 4.0) and 4 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CEACAM4 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41613436..41627074, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44435204..44448818, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42125388..42133442, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372404 Neighboring gene CEA cell adhesion molecule pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 3 Neighboring gene uncharacterized LOC105372405

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria. Delgado Tascón J, et al. J Leukoc Biol, 2015 Mar. PMID 25567962, Free PMC Article
    2. Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. Kuroki M, et al. J Biol Chem, 1991 Jun 25. PMID 2050678
    3. Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells. Wakabayashi-Nakao K, et al. Biomed Res, 2014. PMID 25152032
    4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article
    5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CEACAM4 is expressed in tumor-derived cell lines, and this expression is specific to an medullary thyroid carcinoma derived cell line.
      Title: Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells.
    2. CEACAM4 has phagocytic function.
      Title: The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 4
    Names
    Nonspecific cross-reacting antigen (NCA)
    carcinoembryonic antigen CGM7
    carcinoembryonic antigen gene family member 7
    carcinoembryonic antigen related cell adhesion molecule 4
    carcinoembryonic antigen-related cell adhesion molecule 4-sv1
    carcinoembryonic antigen-related cell adhesion molecule 4-sv2
    non-specific cross-reacting antigen W236
    nonspecific cross-reacting antigen W236

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362492.2 → NP_001349421.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC243960
      UniProtKB/TrEMBL
      A0A077JJN3
      Conserved Domains (1) summary
      cd05774
      Location:37 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    2. NM_001362493.2 → NP_001349422.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC243960

    3. NM_001362495.2 → NP_001349424.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC243960
      UniProtKB/TrEMBL
      A0A077JIU5, M0R363
      Related
      ENSP00000473018.1, ENST00000600925.1
      Conserved Domains (1) summary
      cd05774
      Location:37 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

    4. NM_001817.4 → NP_001808.2  carcinoembryonic antigen-related cell adhesion molecule 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001808.2

      Status: VALIDATED

      Source sequence(s)
      AC005955, AC243960, BF819374, BX644557, BX644579, D90276
      Consensus CDS
      CCDS33033.1
      UniProtKB/Swiss-Prot
      O75871, Q03715, Q7LDZ7
      UniProtKB/TrEMBL
      M0R363
      Related
      ENSP00000221954.2, ENST00000221954.7
      Conserved Domains (2) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44 → 140
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41613436..41627074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026213.2 → XP_016881702.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X16

    2. XM_047438093.1 → XP_047294049.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X15

    3. XM_011526352.2 → XP_011524654.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X12

      See identical proteins and their annotated locations for XP_011524654.1

      UniProtKB/TrEMBL
      M0R363
      Conserved Domains (2) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44 → 140
      IG_like; Immunoglobulin like

    4. XM_011526354.2 → XP_011524656.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X14

      See identical proteins and their annotated locations for XP_011524656.1

      UniProtKB/TrEMBL
      M0R363
      Conserved Domains (2) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44 → 140
      IG_like; Immunoglobulin like

    5. XM_011526343.2 → XP_011524645.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X3

      See identical proteins and their annotated locations for XP_011524645.1

      UniProtKB/TrEMBL
      M0R363
      Conserved Domains (3) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44 → 140
      IG_like; Immunoglobulin like
      pfam07332
      Location:146 → 197
      Phage_holin_3_6; Putative Actinobacterial Holin-X, holin superfamily III

    6. XM_047438092.1 → XP_047294048.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X13

    7. XM_017026200.2 → XP_016881689.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X2

    8. XM_017026211.2 → XP_016881700.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X9

      UniProtKB/TrEMBL
      M0R363

    9. XM_017026199.2 → XP_016881688.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X1

      Conserved Domains (1) summary
      smart00409
      Location:44 → 140
      IG; Immunoglobulin

    10. XM_017026210.2 → XP_016881699.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X8

      UniProtKB/TrEMBL
      M0R363

    11. XM_011526350.3 → XP_011524652.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X10

      See identical proteins and their annotated locations for XP_011524652.1

      UniProtKB/TrEMBL
      M0R363
      Conserved Domains (2) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:44 → 140
      IG_like; Immunoglobulin like

    12. XM_017026212.2 → XP_016881701.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X11

      UniProtKB/TrEMBL
      M0R363

    13. XM_017026206.2 → XP_016881695.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X4

      UniProtKB/TrEMBL
      M0R363

    14. XM_017026209.2 → XP_016881698.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X7

      UniProtKB/TrEMBL
      M0R363

    15. XM_047438094.1 → XP_047294050.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X17

    16. XM_017026207.3 → XP_016881696.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X6

    17. XM_017026205.2 → XP_016881694.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X5

      UniProtKB/TrEMBL
      M0R363

    RNA

    1. XR_001753593.2 RNA Sequence

    2. XR_007066550.1 RNA Sequence

    3. XR_007066549.1 RNA Sequence

    4. XR_001753592.2 RNA Sequence

    5. XR_007066552.1 RNA Sequence

    6. XR_007066551.1 RNA Sequence

    7. XR_001753594.2 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      54927..68561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329428.1 → XP_054185403.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X16

    2. XM_054329412.1 → XP_054185387.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X8

    3. XM_054329395.1 → XP_054185370.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X1

    4. XM_054329396.1 → XP_054185371.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X2

    5. XM_054329421.1 → XP_054185396.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X13

    6. XM_054329398.1 → XP_054185373.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X3

    7. XM_054329420.1 → XP_054185395.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X12

    8. XM_054329426.1 → XP_054185401.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X15

    9. XM_054329423.1 → XP_054185398.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X32

    10. XM_054329403.1 → XP_054185378.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X23

    11. XM_054329401.1 → XP_054185376.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X21

    12. XM_054329410.1 → XP_054185385.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X27

    13. XM_054329408.1 → XP_054185383.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X26

    14. XM_054329419.1 → XP_054185394.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X31

    15. XM_054329427.1 → XP_054185402.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X33

    16. XM_054329413.1 → XP_054185388.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X28

    17. XM_054329397.1 → XP_054185372.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X18

    18. XM_054329400.1 → XP_054185375.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X20

    19. XM_054329418.1 → XP_054185393.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X30

    20. XM_054329399.1 → XP_054185374.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X19

    21. XM_054329404.1 → XP_054185379.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X24

    22. XM_054329402.1 → XP_054185377.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X22

    23. XM_054329405.1 → XP_054185380.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X25

    24. XM_054329414.1 → XP_054185389.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X29

    25. XM_054329417.1 → XP_054185392.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X11

    26. XM_054329407.1 → XP_054185382.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X4

    27. XM_054329416.1 → XP_054185391.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X10

    28. XM_054329411.1 → XP_054185386.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X7

    29. XM_054329415.1 → XP_054185390.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X9

    30. XM_054329422.1 → XP_054185397.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X14

    31. XM_054329424.1 → XP_054185399.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X32

    32. XM_054329425.1 → XP_054185400.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X32

    33. XM_054329406.1 → XP_054185381.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X5

    34. XM_054329409.1 → XP_054185384.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X6

    35. XM_054329429.1 → XP_054185404.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X17

    RNA

    1. XR_008485639.1 RNA Sequence

    2. XR_008485640.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44435204..44448818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319621.1 → XP_054175596.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X16

    2. XM_054319610.1 → XP_054175585.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X37

    3. XM_054319605.1 → XP_054175580.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X35

    4. XM_054319620.1 → XP_054175595.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X15

    5. XM_054319617.1 → XP_054175592.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X12

    6. XM_054319619.1 → XP_054175594.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X14

    7. XM_054319603.1 → XP_054175578.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X3

    8. XM_054319618.1 → XP_054175593.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X13

    9. XM_054319602.1 → XP_054175577.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X2

    10. XM_054319613.1 → XP_054175588.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X9

    11. XM_054319601.1 → XP_054175576.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X1

    12. XM_054319612.1 → XP_054175587.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X8

    13. XM_054319608.1 → XP_054175583.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X36

    14. XM_054319616.1 → XP_054175591.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X38

    15. XM_054319604.1 → XP_054175579.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X34

    16. XM_054319614.1 → XP_054175589.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X10

    17. XM_054319615.1 → XP_054175590.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X11

    18. XM_054319606.1 → XP_054175581.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X4

    19. XM_054319611.1 → XP_054175586.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X7

    20. XM_054319622.1 → XP_054175597.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X17

    21. XM_054319609.1 → XP_054175584.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X6

    22. XM_054319607.1 → XP_054175582.1  carcinoembryonic antigen-related cell adhesion molecule 4 isoform X5

    RNA

    1. XR_008485075.1 RNA Sequence

    2. XR_008485073.1 RNA Sequence

    3. XR_008485072.1 RNA Sequence

    4. XR_008485071.1 RNA Sequence

    5. XR_008485074.1 RNA Sequence

    6. XR_008485076.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75871.2 GenPept UniProtKB/Swiss-Prot:O75871

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