TRIM31 tripartite motif containing 31 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM31provided by HGNC
Official Full Name: tripartite motif containing 31provided by HGNC
Primary source: HGNC:HGNC:16289
See related: Ensembl:ENSG00000204616 MIM:609316; AllianceGenome:HGNC:16289
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RNF; HCG1; HCGI; C6orf13
Summary: This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression: Biased expression in colon (RPKM 26.2), urinary bladder (RPKM 20.1) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p22.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (30102897..30113090, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (29967171..29977357, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (30070674..30080867, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.
Title: An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer.
TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis.
Title: TRIM31 promotes the progression of oral squamous cell carcinoma through upregulating AKT phosphorylation and subsequent cellular glycolysis.
Tripartite motif-containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen-activated protein kinase kinase kinase 7.
Title: Tripartite motif-containing protein 31 confers protection against nonalcoholic steatohepatitis by deactivating mitogen-activated protein kinase kinase kinase 7.
Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.
Title: Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.
CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis.
Title: CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis.
Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.
Title: Increased TRIM31 gene expression is positively correlated with SARS-CoV-2 associated genes TMPRSS2 and TMPRSS4 in gastrointestinal cancers.
Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
Title: Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.
TRIM31 promotes apoptosis via TAK1-mediated activation of NF-kappaB signaling in sepsis-induced myocardial dysfunction.
Title: TRIM31 promotes apoptosis via TAK1-mediated activation of NF-κB signaling in sepsis-induced myocardial dysfunction.
[Effect of TRIM31 Gene Silencing on the Proliferation and Apoptosis of U266 Cells and Its Mechanism].
Title: [Effect of TRIM31 Gene Silencing on the Proliferation and Apoptosis of U266 Cells and Its Mechanism].
TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3.
Title: TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common genetic variation and performance on standardized cognitive tests. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of proneness to anger. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 infection is modestly restricted by human TRIM31. Gene silencing of endogenously expressed TRIM31inhibits viral release, suggesting the interaction between HIV-1 Gag and TRIM31	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of NLRP3 inflammasome complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in viral release from host cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM31

Names: RING-type E3 ubiquitin transferase TRIM31; tripartite motif-containing protein 31

NP_008959.3

EC 2.3.2.27

XP_011512566.1

EC 2.3.2.27

XP_011512567.1

EC 2.3.2.27

XP_011512568.1

EC 2.3.2.27

XP_047274066.1

EC 2.3.2.27

XP_054185701.1

EC 2.3.2.27

XP_054185702.1

EC 2.3.2.27

XP_054185703.1

EC 2.3.2.27

XP_054186198.1

EC 2.3.2.27

XP_054186199.1

EC 2.3.2.27

XP_054186200.1

EC 2.3.2.27

XP_054186201.1

EC 2.3.2.27

XP_054186486.1

EC 2.3.2.27

XP_054186487.1

EC 2.3.2.27

XP_054186488.1

EC 2.3.2.27

XP_054186489.1

EC 2.3.2.27

XP_054186736.1

EC 2.3.2.27

XP_054186970.1

EC 2.3.2.27

XP_054186971.1

EC 2.3.2.27

XP_054186972.1

EC 2.3.2.27

XP_054186973.1

EC 2.3.2.27

XP_054187250.1

EC 2.3.2.27

XP_054210066.1

EC 2.3.2.27

XP_054210067.1

EC 2.3.2.27

XP_054210068.1

EC 2.3.2.27

XP_054210069.1

EC 2.3.2.27

XP_054210070.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007028.5 → NP_008959.3 E3 ubiquitin-protein ligase TRIM31

See identical proteins and their annotated locations for NP_008959.3

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as alpha) represents the longest transcript and encodes the protein.

Source sequence(s)

AF230386, BG403536, BM847963, CB142265

Consensus CDS

CCDS34374.1

UniProtKB/Swiss-Prot

A6NLX6, A9R9Q4, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8, Q9BZY9

UniProtKB/TrEMBL

A0A1U9X8Q7, A0A1U9X8R1, A0A1U9X8S0, A0A1U9X8S1, A0A1U9X8T0, Q2L6J1

Related

ENSP00000365924.3, ENST00000376734.4

Conserved Domains (2) summary

smart00336
Location:90 → 131

BBOX; B-Box-type zinc finger

cd16582
Location:13 → 56

RING-HC_TRIM31_C-V; RING finger, HC subclass, found in tripartite motif-containing protein 31 (TRIM31) and similar proteins

RNA

NR_134870.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK222729, CB142265, DB244000
NR_134871.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as beta) lacks an exon and uses an alternate splice site compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF230387, CB142265, DB244000

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

30102897..30113090 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418110.1 → XP_047274066.1 E3 ubiquitin-protein ligase TRIM31 isoform X3
XM_011514264.2 → XP_011512566.1 E3 ubiquitin-protein ligase TRIM31 isoform X1

See identical proteins and their annotated locations for XP_011512566.1

UniProtKB/TrEMBL

A0A1U9X8R1, A0A1U9X8S0, A0A1U9X8S1, A0A1U9X8T0

Conserved Domains (2) summary

smart00336
Location:90 → 131

BBOX; B-Box-type zinc finger

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING
XM_011514265.2 → XP_011512567.1 E3 ubiquitin-protein ligase TRIM31 isoform X2

See identical proteins and their annotated locations for XP_011512567.1

UniProtKB/TrEMBL

A0A1U9X8R1

Conserved Domains (2) summary

smart00336
Location:90 → 131

BBOX; B-Box-type zinc finger

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING
XM_011514266.1 → XP_011512568.1 E3 ubiquitin-protein ligase TRIM31 isoform X4

See identical proteins and their annotated locations for XP_011512568.1

UniProtKB/TrEMBL

A0A140T9J6

Conserved Domains (2) summary

smart00336
Location:90 → 131

BBOX; B-Box-type zinc finger

pfam15227
Location:16 → 56

zf-C3HC4_4; zinc finger of C3HC4-type, RING