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    RNF139 ring finger protein 139 [ Homo sapiens (human) ]

    Gene ID: 11236, updated on 2-Nov-2024

    Summary

    Official Symbol
    RNF139provided by HGNC
    Official Full Name
    ring finger protein 139provided by HGNC
    Primary source
    HGNC:HGNC:17023
    See related
    Ensembl:ENSG00000170881 MIM:603046; AllianceGenome:HGNC:17023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RCA1; TRC8; HRCA1
    Summary
    The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 33.6), testis (RPKM 25.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RNF139 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (124474880..124488618)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (125607587..125621646)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125487121..125500859)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 12 homolog Neighboring gene RNF139 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125483735-125484236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125486486-125487030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125487031-125487576 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:125487577-125488120 Neighboring gene TatD DNase domain containing 1 Neighboring gene microRNA 6844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27886 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC31961

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity TAS
    Traceable Author Statement
    more info
     
    enables ubiquitin-like protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Derlin-1 retrotranslocation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Derlin-1 retrotranslocation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum quality control compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF139
    Names
    RING-type E3 ubiquitin transferase RNF139
    multiple membrane spanning receptor TRC8
    patched related protein translocated in renal cancer
    translocation in renal carcinoma on chromosome 8 protein
    translocation in renal carcinoma, chromosome 8
    NP_009149.2
    XP_047277266.1
    XP_054189018.1
    XP_054215657.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012158.1 RefSeqGene

      Range
      5114..18852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007218.4NP_009149.2  E3 ubiquitin-protein ligase RNF139

      See identical proteins and their annotated locations for NP_009149.2

      Status: REVIEWED

      Source sequence(s)
      AA455970, BC021571, BM677460, BM804626, CD171728
      Consensus CDS
      CCDS6350.1
      UniProtKB/Swiss-Prot
      B3KMD5, O75485, Q7LDL3, Q8WU17
      Related
      ENSP00000304051.4, ENST00000303545.4
      Conserved Domains (2) summary
      cd16683
      Location:545586
      RING-H2_RNF139; RING finger, H2 subclass, found in RING finger protein 139 (RNF139) and similar proteins
      pfam13705
      Location:19516
      TRC8_N; TRC8 N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      124474880..124488618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421310.1XP_047277266.1  E3 ubiquitin-protein ligase RNF139 isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791784.1 Reference GRCh38.p14 PATCHES

      Range
      9469..23568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333043.1XP_054189018.1  E3 ubiquitin-protein ligase RNF139 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      125607587..125621646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359682.1XP_054215657.1  E3 ubiquitin-protein ligase RNF139 isoform X1