USF2 upstream transcription factor 2, c-fos interacting [Homo sapiens (human)] - Gene

Summary

Official Symbol: USF2provided by HGNC
Official Full Name: upstream transcription factor 2, c-fos interactingprovided by HGNC
Primary source: HGNC:HGNC:12594
See related: Ensembl:ENSG00000105698 MIM:600390; AllianceGenome:HGNC:12594
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FIP; bHLHb12
Summary: This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]
Expression: Ubiquitous expression in fat (RPKM 22.6), spleen (RPKM 20.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (35268962..35279821)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (37813633..37824489)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (35759865..35770724)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long non-coding RNA X-Inactive Specific Transcript (XIST) interacting with USF2 promotes osteogenic differentiation of periodontal ligament stem cells through regulation of WDR72 transcription.
Title: Long non-coding RNA X-Inactive Specific Transcript (XIST) interacting with USF2 promotes osteogenic differentiation of periodontal ligament stem cells through regulation of WDR72 transcription.
WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
Title: WDR3 promotes stem cell-like properties in prostate cancer by inhibiting USF2-mediated transcription of RASSF1A.
USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling.
Title: USF2-mediated upregulation of TXNRD1 contributes to hepatocellular carcinoma progression by activating Akt/mTOR signaling.
Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2.
Title: Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2.
USF2 knockdown downregulates THBS1 to inhibit the TGF-beta signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury.
Title: USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury.
USF2 reduces BMP3 expression via transcriptional activation of miR-34a, thus promoting osteogenic differentiation of BMSCs.
Title: USF2 reduces BMP3 expression via transcriptional activation of miR-34a, thus promoting osteogenic differentiation of BMSCs.
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
Title: Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
Irrelevance of USF2 rs916145 polymorphism with the risk of biliary atresia susceptibility in Southern Chinese children.
Title: Irrelevance of USF2 rs916145 polymorphism with the risk of biliary atresia susceptibility in Southern Chinese children.
USF2 and ATF4 were upregulated in the osteogenic differentiation of periodontal ligament cells
Title: USF2 enhances the osteogenic differentiation of PDLCs by promoting ATF4 transcriptional activities.
This study reported that USF2 (upstream stimulatory factor 2), a basic helix-loop-helix-leucine-zip transcription factor, is necessary for the transcriptional activity of Smurf1 and Smurf2.
Title: USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH121665 (e-PCR)
- UniSTS:134405

RH75657 (e-PCR)
- UniSTS:85342

STS-N20344 (e-PCR)
- UniSTS:49001

STS-S50537 (e-PCR)
- UniSTS:37521

STS-X90824 (e-PCR)
- UniSTS:37522

RH68134 (e-PCR)
- UniSTS:19117

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in late viral transcription	IC Inferred by Curator more info	PubMed
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription from RNA polymerase II promoter by glucose	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription from RNA polymerase II promoter by glucose	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: upstream stimulatory factor 2

Names: c-fos interacting protein; class B basic helix-loop-helix protein 12; major late transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029241.1 RefSeqGene

Range

4970..15829

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001321150.2 → NP_001308079.1 upstream stimulatory factor 2 isoform 3

Status: REVIEWED

Source sequence(s)

AD000684, AI240594, AY147880

Consensus CDS

CCDS82329.1

UniProtKB/Swiss-Prot

Q15853

Related

ENSP00000368429.3, ENST00000379134.7

Conserved Domains (2) summary

cd00083
Location:102 → 164

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

TIGR04211
Location:135 → 202

SH3_and_anchor; SH3 domain protein
NM_003367.4 → NP_003358.1 upstream stimulatory factor 2 isoform 1

See identical proteins and their annotated locations for NP_003358.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).

Source sequence(s)

AD000684, AI240594, AY007087, BC049821, X90825

Consensus CDS

CCDS12452.1

UniProtKB/Swiss-Prot

O00671, O00709, Q05750, Q07952, Q15851, Q15852, Q15853, Q6FI33, Q6YI47

UniProtKB/TrEMBL

B4DLJ1

Related

ENSP00000222305.2, ENST00000222305.8

Conserved Domains (2) summary

cd18923
Location:229 → 308

bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins

pfam06005
Location:290 → 334

ZapB; Cell division protein ZapB
NM_207291.3 → NP_997174.1 upstream stimulatory factor 2 isoform 2

See identical proteins and their annotated locations for NP_997174.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a segment in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.

Source sequence(s)

AD000684, AI240594, AY007087, X90825

Consensus CDS

CCDS12453.1

UniProtKB/Swiss-Prot

Q15853

Related

ENSP00000340633.4, ENST00000343550.9

Conserved Domains (2) summary

cd18923
Location:162 → 241

bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins

pfam06005
Location:223 → 267

ZapB; Cell division protein ZapB

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

35268962..35279821

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005259197.5 → XP_005259254.1 upstream stimulatory factor 2 isoform X1

UniProtKB/TrEMBL

B4DLJ1

Related

ENSP00000471511.1, ENST00000594064.5

Conserved Domains (1) summary

cd18923
Location:229 → 308

bHLHzip_USF2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins
XM_011527260.3 → XP_011525562.1 upstream stimulatory factor 2 isoform X2
XM_011527261.3 → XP_011525563.1 upstream stimulatory factor 2 isoform X3