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    OSM oncostatin M [ Homo sapiens (human) ]

    Gene ID: 5008, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OSMprovided by HGNC
    Official Full Name
    oncostatin Mprovided by HGNC
    Primary source
    HGNC:HGNC:8506
    See related
    Ensembl:ENSG00000099985 MIM:165095; AllianceGenome:HGNC:8506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in bone marrow (RPKM 29.4), appendix (RPKM 5.8) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See OSM in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30262829..30266851, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30726147..30730169, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30658818..30662840, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30637625-30638293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30640698-30641198 Neighboring gene LIF antisense RNA 1 Neighboring gene LIF interleukin 6 family cytokine Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30648163-30648928 Neighboring gene LIF antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30648929-30649693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30650183-30650684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30650685-30651184 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30653067-30653669 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30653670-30654271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30656529-30657028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30659020-30659819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30659820-30660618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30672215-30672804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30673676-30674204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30674205-30674733 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18831 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene TBC1 domain family member 10A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18832 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30700665-30701164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18836 Neighboring gene origin of replication in TBC1D10A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30721337-30722286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13608

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrated MicroRNA-mRNA Profiling Identifies Oncostatin M as a Marker of Mesenchymal-Like ER-Negative/HER2-Negative Breast Cancer. Bottai G, et al. Int J Mol Sci, 2017 Jan 19. PMID 28106823, Free PMC Article
    2. Molecular dissection of human oncostatin M-mediated signal transductions through site-directed mutagenesis. Liu H, et al. Int J Mol Med, 2009 Feb. PMID 19148539
    3. Immunohistochemical localization of oncostatin M in epithelialized apical periodontitis lesions. Tsai CH, et al. Int Endod J, 2008 Sep. PMID 18637848
    4. Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma. Chuerduangphui J, et al. Med Oncol, 2016 Aug. PMID 27349249
    5. Expression of oncostatin M in chronic obstructive sialadenitis of the submandibular gland. Lee HM, et al. Ann Otol Rhinol Laryngol, 2008 May. PMID 18564531

    See all (193) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.
      Title: The causal relationship between immune cells mediating FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.
    2. Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M.
      Title: Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M.
    3. Oncostatin M for characterizing the inflammatory burden and outcome of V-V ECMO in ARDS patients.
      Title: Oncostatin M for characterizing the inflammatory burden and outcome of V-V ECMO in ARDS patients.
    4. Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching.
      Title: Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching.
    5. Role of oncostatin-M in ECM remodeling and plaque vulnerability.
      Title: Role of oncostatin-M in ECM remodeling and plaque vulnerability.
    6. Pancreatic Stromal Cell-derived Oncostatin M Confers Drug Resistance to a Multi-tyrosine Kinase Inhibitor in Pancreatic Cancer Cells.
      Title: Pancreatic Stromal Cell-derived Oncostatin M Confers Drug Resistance to a Multi-tyrosine Kinase Inhibitor in Pancreatic Cancer Cells.
    7. Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps.
      Title: Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps.
    8. Oncostatin M Contributes to Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyps.
      Title: Oncostatin M Contributes to Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyps.
    9. Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis.
      Title: Exogenous Oncostatin M induces Cardiac Dysfunction, Musculoskeletal Atrophy, and Fibrosis.
    10. Oncostatin M Improves Cutaneous Wound Re-Epithelialization and Is Deficient under Diabetic Conditions.
      Title: Oncostatin M Improves Cutaneous Wound Re-Epithelialization and Is Deficient under Diabetic Conditions.
    Submit: New GeneRIF Correction See all GeneRIFs (152)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies susceptibility loci for IgA nephropathy.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of oncostatin M (OSM) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC20461

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oncostatin-M receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oncostatin-M-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of acute inflammatory response IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of positive regulation of interleukin-17 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of hematopoietic stem cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oncostatin-M

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319108.2 → NP_001306037.1  oncostatin-M isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.
      Source sequence(s)
      AC004264, BC011589, BM562358
      Consensus CDS
      CCDS82706.1
      UniProtKB/TrEMBL
      B5BUQ7, B5MCX1
      Related
      ENSP00000383893.1, ENST00000403389.1
      Conserved Domains (1) summary
      pfam01291
      Location:16 → 188
      LIF_OSM; LIF / OSM family

    2. NM_020530.6 → NP_065391.1  oncostatin-M isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_065391.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004264, BC011589, CR981101
      Consensus CDS
      CCDS13873.1
      UniProtKB/Swiss-Prot
      P13725, Q6FHP8, Q9UCP6
      UniProtKB/TrEMBL
      B5BUQ7
      Related
      ENSP00000215781.2, ENST00000215781.3
      Conserved Domains (1) summary
      pfam01291
      Location:37 → 209
      LIF_OSM; LIF / OSM family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      30262829..30266851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441387.1 → XP_047297343.1  oncostatin-M isoform X1

      UniProtKB/TrEMBL
      B5MCX1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      30726147..30730169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325661.1 → XP_054181636.1  oncostatin-M isoform X1

      UniProtKB/TrEMBL
      B5MCX1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13725.2 GenPept UniProtKB/Swiss-Prot:P13725

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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