U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    CNOT6L CCR4-NOT transcription complex subunit 6 like [ Homo sapiens (human) ]

    Gene ID: 246175, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CNOT6Lprovided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 6 likeprovided by HGNC
    Primary source
    HGNC:HGNC:18042
    See related
    Ensembl:ENSG00000138767 MIM:618069; AllianceGenome:HGNC:18042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCR4b
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Involved in positive regulation of cell population proliferation and positive regulation of cytoplasmic mRNA processing body assembly. Located in cytosol and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CNOT6L in Genome Data Viewer
    Location:
    4q21.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (77713387..77820269, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (81054227..81161055, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (78634541..78741423, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 13 Neighboring gene uncharacterized LOC105377296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15505 Neighboring gene uncharacterized LOC105377297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:78691877-78692518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21640 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:78781972-78782187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21642 Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene uncharacterized LOC102724916 Neighboring gene serine and arginine rich splicing factor 10 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. Wang H, et al. EMBO J, 2010 Aug 4. PMID 20628353, Free PMC Article
    2. Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation. Polesskaya A, et al. Biochim Biophys Acta, 2016 Feb. PMID 26608607
    3. Structural basis for inhibition of the deadenylase activity of human CNOT6L. Zhang Q, et al. FEBS Lett, 2016 Apr. PMID 27013054
    4. Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest. Zheng W, et al. J Med Genet, 2022 Sep. PMID 34611029
    5. 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding. Airhihen B, et al. FEBS Open Bio, 2019 Apr. PMID 30984545, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal circCNOT6L Regulates Astrocyte Apoptotic Signals Induced by Hypoxia Exposure Through miR99a-5p/SERPINE1 and Alleviates Ischemic Stroke Injury.
      Title: Exosomal circCNOT6L Regulates Astrocyte Apoptotic Signals Induced by Hypoxia Exposure Through miR99a-5p/SERPINE1 and Alleviates Ischemic Stroke Injury.
    2. Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
      Title: Deadenylase-dependent mRNA decay of GDF15 and FGF21 orchestrates food intake and energy expenditure.
    3. We show that knockdown of human XRN1, CNOT6 and ETF1 genes in HepG2 cells led to significant alteration in stability of specific mRNAs, alterations in half-life were inversely associated with transcription rates, mostly not resulting in changes in abundance
      Title: mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells.
    4. Studied hepatic role in metabolic homeostasis of fibroblast growth factor 21(FGF21) and the "CCR4-NOT complex" (a multisubunit protein complex composed of "CCR4-NOT transcription complex subunit 6 like" (CNOT6L) and "CCR4-NOT transcription complex subunit 6" (CNOT6). Results show CNOT6L plays a major role in regulation FGF21 levels.
      Title: Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.
    5. Active 1-hydroxy-xanthines inhibit both isolated Caf1 (CNOT7) enzyme and human Caf1-containing complexes that also contain the second nuclease subunit Ccr4 (CNOT6L) to a similar extent, indicating that the active site of the Caf1 nuclease subunit does not undergo substantial conformational change when bound to other Ccr4-Not subunits.
      Title: 1-Hydroxy-xanthine derivatives inhibit the human Caf1 nuclease and Caf1-containing nuclease complexes via Mg(2+)-dependent binding.
    6. Structural analysis shows that all inhibitors occupy the substrate and magnesium-binding sites of CNOT6L, suggesting that inhibitors compete with both substrate and divalent magnesium ions for overlapping binding sites.
      Title: Structural basis for inhibition of the deadenylase activity of human CNOT6L.
    7. Data show that CNOT6L protein-interleukin 8 (IL-8) is a signaling axis in myogenesis.
      Title: Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation.
    8. Cnot6L, a validated target of miR-146a, affects the stability of Zeb1 mRNA.
      Title: Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.
    9. Results identified CNOT6/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5, which mediates cell cycle arrest and senescence via a p53-dependent pathway.
      Title: The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.
    10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A Bayesian approach to genetic association studies with family-based designs.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A)-specific ribonuclease activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening TAS
    Traceable Author Statement
    more info
    		  
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytoplasmic mRNA processing body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of CCR4-NOT complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CCR4-NOT transcription complex subunit 6-like
    Names
    carbon catabolite repressor protein 4 homolog B
    NP_001273719.1
    NP_001351935.1
    NP_001351936.1
    NP_001374764.1
    NP_001374765.1
    NP_001374766.1
    NP_001374767.1
    NP_001374768.1
    NP_001374769.1
    NP_001374770.1
    NP_001374771.1
    NP_001374772.1
    NP_653172.2
    XP_011530108.1
    XP_011530109.1
    XP_011530110.1
    XP_011530111.1
    XP_047305918.1
    XP_047305919.1
    XP_054205474.1
    XP_054205475.1
    XP_054205476.1
    XP_054205477.1
    XP_054205478.1
    XP_054205479.1
    XP_054205480.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286790.2 → NP_001273719.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_001273719.1

      Status: VALIDATED

      Source sequence(s)
      AC104701, AK303417, AL133112
      UniProtKB/Swiss-Prot
      Q96LI5, Q9UF92
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191 → 538
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57 → 183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:38 → 57
      LRR_1; leucine-rich repeat [structural motif]

    2. NM_001365006.1 → NP_001351935.1  CCR4-NOT transcription complex subunit 6-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:186 → 541
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:53 → 75
      LRR_RI; leucine-rich repeat [structural motif]

    3. NM_001365007.2 → NP_001351936.1  CCR4-NOT transcription complex subunit 6-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:186 → 541
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:53 → 75
      LRR_RI; leucine-rich repeat [structural motif]

    4. NM_001387835.1 → NP_001374764.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Conserved Domains (3) summary
      cd10312
      Location:186 → 533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:33 → 52
      LRR_1; leucine-rich repeat [structural motif]

    5. NM_001387836.1 → NP_001374765.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Related
      ENSP00000425571.2, ENST00000512485.6
      Conserved Domains (3) summary
      cd10312
      Location:186 → 533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:33 → 52
      LRR_1; leucine-rich repeat [structural motif]

    6. NM_001387837.1 → NP_001374766.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Related
      ENSP00000497467.1, ENST00000649644.1
      Conserved Domains (3) summary
      cd10312
      Location:186 → 533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:33 → 52
      LRR_1; leucine-rich repeat [structural motif]

    7. NM_001387838.1 → NP_001374767.1  CCR4-NOT transcription complex subunit 6-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93552.1
      UniProtKB/TrEMBL
      B4E0K8, H0Y9Z5
      Conserved Domains (3) summary
      cd10312
      Location:186 → 533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:33 → 52
      LRR_1; leucine-rich repeat [structural motif]

    8. NM_001387839.1 → NP_001374768.1  CCR4-NOT transcription complex subunit 6-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93553.1
      UniProtKB/TrEMBL
      H0Y9C1
      Conserved Domains (3) summary
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:33 → 52
      LRR_1; leucine-rich repeat [structural motif]
      cl00490
      Location:186 → 434
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    9. NM_001387840.1 → NP_001374769.1  CCR4-NOT transcription complex subunit 6-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104701
      Consensus CDS
      CCDS93553.1
      UniProtKB/TrEMBL
      H0Y9C1
      Related
      ENSP00000423750.2, ENST00000515506.6
      Conserved Domains (3) summary
      COG4886
      Location:52 → 178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:33 → 52
      LRR_1; leucine-rich repeat [structural motif]
      cl00490
      Location:186 → 434
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    10. NM_001387841.1 → NP_001374770.1  CCR4-NOT transcription complex subunit 6-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191 → 570
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57 → 183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:38 → 57
      LRR_1; leucine-rich repeat [structural motif]

    11. NM_001387842.1 → NP_001374771.1  CCR4-NOT transcription complex subunit 6-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:252 → 599
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:118 → 244
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:99 → 118
      LRR_1; leucine-rich repeat [structural motif]

    12. NM_001387843.1 → NP_001374772.1  CCR4-NOT transcription complex subunit 6-like isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104701
      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:252 → 599
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:118 → 244
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:99 → 118
      LRR_1; leucine-rich repeat [structural motif]

    13. NM_144571.3 → NP_653172.2  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_653172.2

      Status: VALIDATED

      Source sequence(s)
      AC104701, AL133112, DA043791, DB454180
      UniProtKB/Swiss-Prot
      Q96LI5, Q9UF92
      UniProtKB/TrEMBL
      B4E0K8
      Related
      ENSP00000424896.1, ENST00000504123.7
      Conserved Domains (3) summary
      cd10312
      Location:191 → 538
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57 → 183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:38 → 57
      LRR_1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      77713387..77820269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531809.2 → XP_011530111.1  CCR4-NOT transcription complex subunit 6-like isoform X4

      See identical proteins and their annotated locations for XP_011530111.1

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191 → 546
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57 → 183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:58 → 80
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_011531807.4 → XP_011530109.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (4) summary
      cd10312
      Location:230 → 577
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      sd00033
      Location:97 → 119
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:95 → 135
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:95 → 176
      LRR_8; Leucine rich repeat

    3. XM_011531806.4 → XP_011530108.1  CCR4-NOT transcription complex subunit 6-like isoform X1

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (4) summary
      cd10312
      Location:230 → 585
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      sd00033
      Location:97 → 119
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:95 → 135
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:95 → 176
      LRR_8; Leucine rich repeat

    4. XM_011531808.3 → XP_011530110.1  CCR4-NOT transcription complex subunit 6-like isoform X3

      See identical proteins and their annotated locations for XP_011530110.1

      UniProtKB/TrEMBL
      B4E0K8
      Conserved Domains (3) summary
      cd10312
      Location:191 → 546
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57 → 183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:58 → 80
      LRR_RI; leucine-rich repeat [structural motif]

    5. XM_047449963.1 → XP_047305919.1  CCR4-NOT transcription complex subunit 6-like isoform X6

      UniProtKB/TrEMBL
      H0Y9Z5

    6. XM_047449962.1 → XP_047305918.1  CCR4-NOT transcription complex subunit 6-like isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      81054227..81161055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349502.1 → XP_054205477.1  CCR4-NOT transcription complex subunit 6-like isoform X4

    2. XM_054349500.1 → XP_054205475.1  CCR4-NOT transcription complex subunit 6-like isoform X2

    3. XM_054349499.1 → XP_054205474.1  CCR4-NOT transcription complex subunit 6-like isoform X1

    4. XM_054349501.1 → XP_054205476.1  CCR4-NOT transcription complex subunit 6-like isoform X3

    5. XM_054349504.1 → XP_054205479.1  CCR4-NOT transcription complex subunit 6-like isoform X6

      UniProtKB/TrEMBL
      H0Y9Z5

    6. XM_054349505.1 → XP_054205480.1  CCR4-NOT transcription complex subunit 6-like isoform X6

      UniProtKB/TrEMBL
      H0Y9Z5

    7. XM_054349503.1 → XP_054205478.1  CCR4-NOT transcription complex subunit 6-like isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LI5.2 GenPept UniProtKB/Swiss-Prot:Q96LI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous