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    NPY5R neuropeptide Y receptor Y5 [ Homo sapiens (human) ]

    Gene ID: 4889, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NPY5Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y5provided by HGNC
    Primary source
    HGNC:HGNC:7958
    See related
    Ensembl:ENSG00000164129 MIM:602001; AllianceGenome:HGNC:7958
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPYR5; NPY5-R; NPYY5-R
    Summary
    The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in spleen (RPKM 1.2), fat (RPKM 1.1) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NPY5R in Genome Data Viewer
    Location:
    4q32.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (163343892..163352403)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (166691703..166700212)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164265044..164273086)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75696 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:164238175-164238759 Neighboring gene neuropeptide Y receptor Y1 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:164336685-164337439 Neighboring gene transketolase like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of human neuropeptide Y receptor subtype five specific antagonists using a luciferase reporter gene assay. Beauverger P, et al. Cell Signal, 2005 Apr. PMID 15601626
    2. Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters. Chatree S, et al. Exp Biol Med (Maywood), 2018 May. PMID 29763369, Free PMC Article
    3. Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. Czarnecka M, et al. Oncogene, 2015 Jun 11. PMID 25132261, Free PMC Article
    4. Molecular identification of the long isoform of the human neuropeptide Y Y5 receptor and pharmacological comparison with the short Y5 receptor isoform. Rodriguez M, et al. Biochem J, 2003 Feb 1. PMID 12398768, Free PMC Article
    5. Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control. Nichol KA, et al. J Neurosci, 1999 Dec 1. PMID 10575027, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.
      Title: Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor.
    2. Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
      Title: Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
    3. Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
      Title: Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.
    4. Y1R and Y5R might be the dominant receptors that mediate the effect of NPY-induced fat accumulation in both subcutaneous and visceral adipose tissues. Y1R and Y5R in visceral adipose tissue might be targets of drug development in prevention or treatment of obesity.
      Title: Adipose Y5R mRNA is higher in obese than non-obese humans and is correlated with obesity parameters.
    5. NPY5R is an inducible pro-survival factor that is responsible for chemoresistance in neuroblastoma cells.
      Title: Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.
    6. Variations in genes AGRP, CPE, GHRL, GLP1R, HTR2A, NPY1R, NPY5R, SOCS3 and STAT3 showed modest associations with BMI in European Americans.
      Title: Genetic association analysis of 30 genes related to obesity in a European American population.
    7. these data highlight a novel mechanism by which NPY may promote breast cancer progression, and further implicate a pathological role of the NPY Y5R.
      Title: Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis.
    8. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Analysis of copy number variation in 8,842 Korean individuals reveals 39 genes associated with hepatic biomarkers AST and ALT.
    9. Together, our results suggest that Y5R plays an important role in cancer cell growth and migration and could be a novel therapeutic target for breast cancer.
      Title: Neuropeptide Y Y5 receptor promotes cell growth through extracellular signal-regulated kinase signaling and cyclic AMP inhibition in a human breast cancer cell line.
    10. NPY1R and NPY5R have roles in nutrient-specific food intake in Europeans
      Title: Variants in neuropeptide Y receptor 1 and 5 are associated with nutrient-specific food intake and are under recent selection in Europeans.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide Y receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pancreatic polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide YY receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in generation of ovulation cycle rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of acute inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of acute inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic signaling via neuropeptide IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuropeptide Y receptor type 5
    Names
    NPY-Y5 receptor
    Y5 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317091.2 → NP_001304020.1  neuropeptide Y receptor type 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      BC034224
      Consensus CDS
      CCDS3804.1
      UniProtKB/Swiss-Prot
      Q15761, Q6GTR7, Q92916
      Related
      ENSP00000423917.1, ENST00000515560.1
      Conserved Domains (1) summary
      cd15398
      Location:42 → 436
      7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001317092.2 → NP_001304021.1  neuropeptide Y receptor type 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC042416, HY025097
      Consensus CDS
      CCDS3804.1
      UniProtKB/Swiss-Prot
      Q15761, Q6GTR7, Q92916
      Conserved Domains (1) summary
      cd15398
      Location:42 → 436
      7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_006174.4 → NP_006165.1  neuropeptide Y receptor type 5

      See identical proteins and their annotated locations for NP_006165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC042416, BI464162
      Consensus CDS
      CCDS3804.1
      UniProtKB/Swiss-Prot
      Q15761, Q6GTR7, Q92916
      Related
      ENSP00000339377.3, ENST00000338566.8
      Conserved Domains (1) summary
      cd15398
      Location:42 → 436
      7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      163343892..163352403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011532017.3 → XP_011530319.1  neuropeptide Y receptor type 5 isoform X2

      See identical proteins and their annotated locations for XP_011530319.1

      UniProtKB/Swiss-Prot
      Q15761, Q6GTR7, Q92916
      Conserved Domains (1) summary
      cd15398
      Location:42 → 436
      7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_005263038.4 → XP_005263095.1  neuropeptide Y receptor type 5 isoform X2

      See identical proteins and their annotated locations for XP_005263095.1

      UniProtKB/Swiss-Prot
      Q15761, Q6GTR7, Q92916
      Conserved Domains (1) summary
      cd15398
      Location:42 → 436
      7tmA_NPY5R; neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_017008256.2 → XP_016863745.1  neuropeptide Y receptor type 5 isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:65 → 432
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56 → 178
      7tm_4; Olfactory receptor

    4. XM_011532015.3 → XP_011530317.1  neuropeptide Y receptor type 5 isoform X1

      See identical proteins and their annotated locations for XP_011530317.1

      Conserved Domains (2) summary
      pfam00001
      Location:65 → 432
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56 → 178
      7tm_4; Olfactory receptor

    5. XM_047415745.1 → XP_047271701.1  neuropeptide Y receptor type 5 isoform X1

    6. XM_017008255.2 → XP_016863744.1  neuropeptide Y receptor type 5 isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:65 → 432
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56 → 178
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      166691703..166700212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350126.1 → XP_054206101.1  neuropeptide Y receptor type 5 isoform X2

      UniProtKB/Swiss-Prot
      Q15761, Q6GTR7, Q92916

    2. XM_054350125.1 → XP_054206100.1  neuropeptide Y receptor type 5 isoform X2

      UniProtKB/Swiss-Prot
      Q15761, Q6GTR7, Q92916

    3. XM_054350122.1 → XP_054206097.1  neuropeptide Y receptor type 5 isoform X1

    4. XM_054350121.1 → XP_054206096.1  neuropeptide Y receptor type 5 isoform X1

    5. XM_054350124.1 → XP_054206099.1  neuropeptide Y receptor type 5 isoform X1

    6. XM_054350123.1 → XP_054206098.1  neuropeptide Y receptor type 5 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15761.2 GenPept UniProtKB/Swiss-Prot:Q15761

    Gene LinkOut

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