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    DPY19L4 dpy-19 like 4 [ Homo sapiens (human) ]

    Gene ID: 286148, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DPY19L4provided by HGNC
    Official Full Name
    dpy-19 like 4provided by HGNC
    Primary source
    HGNC:HGNC:27829
    See related
    Ensembl:ENSG00000156162 MIM:613895; AllianceGenome:HGNC:27829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable mannosyltransferase activity. Predicted to be located in membrane. Predicted to be active in nuclear inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.0), ovary (RPKM 7.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DPY19L4 in Genome Data Viewer
    Location:
    8q22.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (94719900..94793836)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (95844880..95918818)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (95732128..95806064)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27633 Neighboring gene long intergenic non-protein coding RNA 2894 Neighboring gene epithelial splicing regulatory protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27634 Neighboring gene ribosomal protein S15a pseudogene 26 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:95731221-95732175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27635 Neighboring gene integrator complex subunit 8 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene cyclin E2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. Tsuritani K, et al. Genome Res, 2007 Jul. PMID 17567985, Free PMC Article
    2. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article
    3. From ORFeome to biology: a functional genomics pipeline. Wiemann S, et al. Genome Res, 2004 Oct. PMID 15489336, Free PMC Article
    4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
    5. DNA cloning using in vitro site-specific recombination. Hartley JL, et al. Genome Res, 2000 Nov. PMID 11076863, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC131885

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable C-mannosyltransferase DPY19L4
    Names
    dpy-19-like protein 4
    protein dpy-19 homolog 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181787.3 → NP_861452.2  probable C-mannosyltransferase DPY19L4

      See identical proteins and their annotated locations for NP_861452.2

      Status: VALIDATED

      Source sequence(s)
      AP003692, BC110870, BP873374
      Consensus CDS
      CCDS34924.1
      UniProtKB/Swiss-Prot
      Q6ZW32, Q6ZW42, Q7Z329, Q7Z388
      Related
      ENSP00000389630.2, ENST00000414645.6
      Conserved Domains (1) summary
      pfam10034
      Location:62 → 714
      Dpy19; Q-cell neuroblast polarization

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      94719900..94793836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250894.5 → XP_005250951.2  probable C-mannosyltransferase DPY19L4 isoform X1

    2. XM_047421714.1 → XP_047277670.1  probable C-mannosyltransferase DPY19L4 isoform X2

    3. XM_011516983.4 → XP_011515285.1  probable C-mannosyltransferase DPY19L4 isoform X3

      Conserved Domains (1) summary
      pfam10034
      Location:62 → 681
      Dpy19; Q-cell neuroblast polarization

    4. XM_017013351.3 → XP_016868840.1  probable C-mannosyltransferase DPY19L4 isoform X5

    5. XM_011516984.4 → XP_011515286.1  probable C-mannosyltransferase DPY19L4 isoform X4

      Conserved Domains (1) summary
      pfam10034
      Location:62 → 672
      Dpy19; Q-cell neuroblast polarization

    6. XM_017013352.3 → XP_016868841.1  probable C-mannosyltransferase DPY19L4 isoform X6

    7. XM_047421715.1 → XP_047277671.1  probable C-mannosyltransferase DPY19L4 isoform X7

    8. XM_047421716.1 → XP_047277672.1  probable C-mannosyltransferase DPY19L4 isoform X8

    9. XM_047421717.1 → XP_047277673.1  probable C-mannosyltransferase DPY19L4 isoform X9

    10. XM_047421718.1 → XP_047277674.1  probable C-mannosyltransferase DPY19L4 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      95844880..95918818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360333.1 → XP_054216308.1  probable C-mannosyltransferase DPY19L4 isoform X1

    2. XM_054360334.1 → XP_054216309.1  probable C-mannosyltransferase DPY19L4 isoform X2

    3. XM_054360335.1 → XP_054216310.1  probable C-mannosyltransferase DPY19L4 isoform X3

    4. XM_054360337.1 → XP_054216312.1  probable C-mannosyltransferase DPY19L4 isoform X5

    5. XM_054360336.1 → XP_054216311.1  probable C-mannosyltransferase DPY19L4 isoform X4

    6. XM_054360338.1 → XP_054216313.1  probable C-mannosyltransferase DPY19L4 isoform X6

    7. XM_054360339.1 → XP_054216314.1  probable C-mannosyltransferase DPY19L4 isoform X7

    8. XM_054360340.1 → XP_054216315.1  probable C-mannosyltransferase DPY19L4 isoform X8

    9. XM_054360341.1 → XP_054216316.1  probable C-mannosyltransferase DPY19L4 isoform X9

    10. XM_054360342.1 → XP_054216317.1  probable C-mannosyltransferase DPY19L4 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z388.1 GenPept UniProtKB/Swiss-Prot:Q7Z388

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