CDC14B cell division cycle 14B [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC14Bprovided by HGNC
Official Full Name: cell division cycle 14Bprovided by HGNC
Primary source: HGNC:HGNC:1719
See related: Ensembl:ENSG00000081377 MIM:603505; AllianceGenome:HGNC:1719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDC14B3; Cdc14B1; Cdc14B2; hCDC14B
Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 5.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q22.32-q22.33

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (96490939..96619843, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (108663606..108791618, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (99262390..99382125, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans.
Title: The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans.
CDC14B is a favorable biomarker for recurrence and prognosis of GBM.
Title: CDC14B is a favorable biomarker for recurrence and prognosis of GBM.
Downregulation of CDC14B in 5218 breast cancer patients: A novel prognosticator for triple-negative breast cancer.
Title: Downregulation of CDC14B in 5218 breast cancer patients: A novel prognosticator for triple-negative breast cancer.
Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
Title: Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
MiR-1247-5p Functions as a Tumor Suppressor in Human Astroglioma Cells by Targeting CDC14B.
Title: MiR-1247-5p Functions as a Tumor Suppressor in Human Astroglioma Cells by Targeting CDC14B.
miR-1225 targets CDC14B 3'-UTR and recovery of CDC14B expression counteracted the suppressive influence of miR-1225 on laryngeal cancer cells
Title: MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B.
The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer.
Title: Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations.
hCdc14B promotes reactivation of rDNA transcription by dephosphorylating TAFI110. SIRT1 becomes transiently enriched in nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68 destabilizing SL1 binding to the rDNA promoter
Title: Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.
CDC14B expression is downregulated in clear cell renal carinoma, suggesting its role in renal carcinogenesis
Title: Loss of CDC14B expression in clear cell renal cell carcinoma: meta-analysis of microarray data sets.
CDC (cell division cycle) 14A/B phosphatases associate with KIBRA, and CDK1-non-phosphorylatable KIBRA has greatly reduced interaction with CDC14B.
Title: Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

RH103784 (e-PCR)
- UniSTS:98109

STS-N29550 (e-PCR)
- UniSTS:43850

D10S16 (e-PCR)
- UniSTS:155756

D9S1145 (e-PCR)
- UniSTS:49299

RH65524 (e-PCR)
- UniSTS:28318

D9S1011E (e-PCR)
- UniSTS:73644

GDB:335751 (e-PCR)
- UniSTS:156601

SGC38141 (e-PCR)
- UniSTS:25788

STS-H84156 (e-PCR)
- UniSTS:35786

RH119282 (e-PCR)
- UniSTS:133844

SGC35176 (e-PCR)
- UniSTS:62441

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of exit from mitosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dual specificity protein phosphatase CDC14B

Names: CDC14 cell division cycle 14 homolog B

NP_001070649.1

EC 3.1.3.16

EC 3.1.3.48

NP_001338496.1

EC 3.1.3.16

EC 3.1.3.48

NP_001338497.1

EC 3.1.3.16

EC 3.1.3.48

NP_001338498.1

EC 3.1.3.16

EC 3.1.3.48

NP_001338499.1

EC 3.1.3.16

EC 3.1.3.48

NP_003662.1

EC 3.1.3.16

EC 3.1.3.48

NP_201588.1

EC 3.1.3.16

EC 3.1.3.48

XP_011517449.2

EC 3.1.3.16

EC 3.1.3.48

XP_011517450.2

EC 3.1.3.16

EC 3.1.3.48

XP_011517451.2

EC 3.1.3.16

EC 3.1.3.48

XP_011517453.2

EC 3.1.3.16

EC 3.1.3.48

XP_011517455.2

EC 3.1.3.16

EC 3.1.3.48

XP_011517458.2

EC 3.1.3.16

EC 3.1.3.48

XP_016870729.2

EC 3.1.3.16

EC 3.1.3.48

XP_016870730.2

EC 3.1.3.16

EC 3.1.3.48

XP_016870731.1

EC 3.1.3.16

EC 3.1.3.48

XP_016870733.1

EC 3.1.3.16

EC 3.1.3.48

XP_016870734.1

EC 3.1.3.16

EC 3.1.3.48

XP_016870736.1

EC 3.1.3.16

EC 3.1.3.48

XP_016870737.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279953.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279954.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279955.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279956.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279957.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279958.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279959.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279960.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279961.1

EC 3.1.3.16

EC 3.1.3.48

XP_047279962.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220045.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220046.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220047.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220048.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220049.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220050.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220051.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220052.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220053.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220054.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220055.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220056.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220057.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220058.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220059.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220060.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220061.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220062.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220063.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220064.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220065.1

EC 3.1.3.16

EC 3.1.3.48

XP_054220066.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077181.3 → NP_001070649.1 dual specificity protein phosphatase CDC14B isoform 3

See identical proteins and their annotated locations for NP_001070649.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 2, resulting in a protein (isoform 3) that has an alternate N-terminus, compared to isoform 2.

Source sequence(s)

AK126388, AL133477, BQ004840

Consensus CDS

CCDS43853.1

UniProtKB/TrEMBL

H7C3U8

Related

ENSP00000364390.3, ENST00000375242.7

Conserved Domains (2) summary

pfam14671
Location:15 → 152

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:209 → 323

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001351567.3 → NP_001338496.1 dual specificity protein phosphatase CDC14B isoform 4

Status: REVIEWED

Source sequence(s)

AF064104, AI921238, AL353578, BF979799, EF611343

Consensus CDS

CCDS87662.1

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001351568.3 → NP_001338497.1 dual specificity protein phosphatase CDC14B isoform 5

Status: REVIEWED

Source sequence(s)

AI921238, BF979799, DB089608, EF611343

UniProtKB/TrEMBL

A0A9L9PY50, H7C3U8

Related

ENSP00000516645.1, ENST00000481149.2

Conserved Domains (2) summary

cd14499
Location:162 → 335

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:11 → 153

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001351569.2 → NP_001338498.1 dual specificity protein phosphatase CDC14B isoform 5

Status: REVIEWED

Source sequence(s)

AK126388, AL133477, BP272794, BQ004840, DA943563

UniProtKB/TrEMBL

A0A9L9PY50, H7C3U8

Conserved Domains (2) summary

cd14499
Location:162 → 335

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:11 → 153

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_001351570.1 → NP_001338499.1 dual specificity protein phosphatase CDC14B isoform 6

Status: REVIEWED

Source sequence(s)

AK126388, AL133477, BG709497, BP272794, BQ004840, DB089608

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:223 → 337

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_003671.5 → NP_003662.1 dual specificity protein phosphatase CDC14B isoform 1

See identical proteins and their annotated locations for NP_003662.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment in the C-terminal region, compared to isoform 2.

Source sequence(s)

AF064104, AL133477, AL353578, BQ004840

Consensus CDS

CCDS6721.1

UniProtKB/TrEMBL

H7C3U8

Related

ENSP00000364388.3, ENST00000375240.7

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
NM_033331.4 → NP_201588.1 dual specificity protein phosphatase CDC14B isoform 2

See identical proteins and their annotated locations for NP_201588.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (2).

Source sequence(s)

AF064104, AL133477, AL353578, BQ004840

Consensus CDS

CCDS6722.1

UniProtKB/Swiss-Prot

A6N5X8, A8MQ20, B1AL31, B1AL32, O43183, O60729, O60730, Q5JU08

UniProtKB/TrEMBL

H7C3U8

Related

ENSP00000364389.1, ENST00000375241.6

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

RNA

NR_147239.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AF064104, AK225361, AL133477, AL353578, BQ004840

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

96490939..96619843 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047423999.1 → XP_047279955.1 dual specificity protein phosphatase CDC14B isoform X13

Related

ENSP00000417897.1, ENST00000474602.5
XM_011519147.4 → XP_011517449.2 dual specificity protein phosphatase CDC14B isoform X2

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:223 → 337

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_011519149.4 → XP_011517451.2 dual specificity protein phosphatase CDC14B isoform X4

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:223 → 337

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_017015248.3 → XP_016870737.1 dual specificity protein phosphatase CDC14B isoform X18
XM_047424000.1 → XP_047279956.1 dual specificity protein phosphatase CDC14B isoform X14
XM_017015242.3 → XP_016870731.1 dual specificity protein phosphatase CDC14B isoform X8

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

cd14499
Location:199 → 372

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:52 → 190

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_047424004.1 → XP_047279960.1 dual specificity protein phosphatase CDC14B isoform X19
XM_047424003.1 → XP_047279959.1 dual specificity protein phosphatase CDC14B isoform X17
XM_047424001.1 → XP_047279957.1 dual specificity protein phosphatase CDC14B isoform X15
XM_011519156.4 → XP_011517458.2 dual specificity protein phosphatase CDC14B isoform X9
XM_017015247.3 → XP_016870736.1 dual specificity protein phosphatase CDC14B isoform X16

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

cd14499
Location:162 → 335

CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins

cd17657
Location:11 → 153

CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins
XM_017015244.3 → XP_016870733.1 dual specificity protein phosphatase CDC14B isoform X11

UniProtKB/TrEMBL

H7C3U8
XM_017015241.3 → XP_016870730.2 dual specificity protein phosphatase CDC14B isoform X7

Conserved Domains (2) summary

pfam14671
Location:29 → 117

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:154 → 268

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_011519153.4 → XP_011517455.2 dual specificity protein phosphatase CDC14B isoform X6

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:223 → 337

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_011519148.4 → XP_011517450.2 dual specificity protein phosphatase CDC14B isoform X3

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:223 → 337

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_017015240.3 → XP_016870729.2 dual specificity protein phosphatase CDC14B isoform X1

UniProtKB/TrEMBL

A4D255

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:223 → 337

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_047424002.1 → XP_047279958.1 dual specificity protein phosphatase CDC14B isoform X15
XM_047424005.1 → XP_047279961.1 dual specificity protein phosphatase CDC14B isoform X20
XM_047424006.1 → XP_047279962.1 dual specificity protein phosphatase CDC14B isoform X21
XM_047423997.1 → XP_047279953.1 dual specificity protein phosphatase CDC14B isoform X5
XM_047423998.1 → XP_047279954.1 dual specificity protein phosphatase CDC14B isoform X10

Related

ENSP00000420572.1, ENST00000463569.5
XM_017015245.2 → XP_016870734.1 dual specificity protein phosphatase CDC14B isoform X12

UniProtKB/TrEMBL

H7C3U8
XM_011519151.4 → XP_011517453.2 dual specificity protein phosphatase CDC14B isoform X5

UniProtKB/TrEMBL

H7C3U8

Conserved Domains (2) summary

pfam14671
Location:29 → 166

DSPn; Dual specificity protein phosphatase, N-terminal half

cl21483
Location:223 → 337

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RNA

XR_007061367.1 RNA Sequence
XR_007061366.1 RNA Sequence
XR_929864.4 RNA Sequence
XR_929865.4 RNA Sequence
XR_001746406.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

108663606..108791618 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054364083.1 → XP_054220058.1 dual specificity protein phosphatase CDC14B isoform X13
XM_054364071.1 → XP_054220046.1 dual specificity protein phosphatase CDC14B isoform X2
XM_054364073.1 → XP_054220048.1 dual specificity protein phosphatase CDC14B isoform X4
XM_054364088.1 → XP_054220063.1 dual specificity protein phosphatase CDC14B isoform X18
XM_054364084.1 → XP_054220059.1 dual specificity protein phosphatase CDC14B isoform X14
XM_054364078.1 → XP_054220053.1 dual specificity protein phosphatase CDC14B isoform X8
XM_054364089.1 → XP_054220064.1 dual specificity protein phosphatase CDC14B isoform X19
XM_054364087.1 → XP_054220062.1 dual specificity protein phosphatase CDC14B isoform X17
XM_054364085.1 → XP_054220060.1 dual specificity protein phosphatase CDC14B isoform X15
XM_054364079.1 → XP_054220054.1 dual specificity protein phosphatase CDC14B isoform X9
XM_054364086.1 → XP_054220061.1 dual specificity protein phosphatase CDC14B isoform X16
XM_054364081.1 → XP_054220056.1 dual specificity protein phosphatase CDC14B isoform X11
XM_054364077.1 → XP_054220052.1 dual specificity protein phosphatase CDC14B isoform X7
XM_054364076.1 → XP_054220051.1 dual specificity protein phosphatase CDC14B isoform X6
XM_054364072.1 → XP_054220047.1 dual specificity protein phosphatase CDC14B isoform X3
XM_054364070.1 → XP_054220045.1 dual specificity protein phosphatase CDC14B isoform X1
XM_054364090.1 → XP_054220065.1 dual specificity protein phosphatase CDC14B isoform X20
XM_054364091.1 → XP_054220066.1 dual specificity protein phosphatase CDC14B isoform X21
XM_054364075.1 → XP_054220050.1 dual specificity protein phosphatase CDC14B isoform X5
XM_054364080.1 → XP_054220055.1 dual specificity protein phosphatase CDC14B isoform X10
XM_054364082.1 → XP_054220057.1 dual specificity protein phosphatase CDC14B isoform X12
XM_054364074.1 → XP_054220049.1 dual specificity protein phosphatase CDC14B isoform X5

RNA

XR_008488099.1 RNA Sequence
XR_008488096.1 RNA Sequence
XR_008488097.1 RNA Sequence
XR_008488098.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_033332.1: Suppressed sequence

Description

NM_033332.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.