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    ADAM21 ADAM metallopeptidase domain 21 [ Pan paniscus (pygmy chimpanzee) ]

    Gene ID: 100969567, updated on 10-Oct-2024

    Summary

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    Gene symbol
    ADAM21
    Gene description
    ADAM metallopeptidase domain 21
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan paniscus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human all
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    Genomic context

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    See ADAM21 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanPan1-v2.0_pri (GCF_029289425.2) 15 NC_073264.2 (71539713..71581469)
    RS_2023_05 previous assembly NHGRI_mPanPan1-v1.1-0.1.freeze_pri (GCF_029289425.1) 14 NC_073263.1 (70756226..70797982)

    Chromosome 15 - NC_073264.2Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Neighboring gene transcription factor NF-E4-like Neighboring gene U2 spliceosomal RNA Neighboring gene synaptojanin 2 binding protein Neighboring gene disintegrin and metalloproteinase domain-containing protein 20-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sperm head plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_029289425.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

    Genomic

    1. NC_073264.2 Reference NHGRI_mPanPan1-v2.0_pri Primary Assembly

      Range
      71539713..71581469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_034937733.2 → XP_034793624.1  disintegrin and metalloproteinase domain-containing protein 21

      UniProtKB/TrEMBL
      A0A2R9AB15
      Conserved Domains (4) summary
      smart00608
      Location:491 → 627
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:208 → 396
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:415 → 487
      Disintegrin
      pfam01562
      Location:41 → 159
      Pep_M12B_propep; Reprolysin family propeptide

    2. XM_055097743.2 → XP_054953718.1  disintegrin and metalloproteinase domain-containing protein 21

    Nucleotide Protein
    Heading Accession and Version

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