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    Klrb1f killer cell lectin-like receptor subfamily B member 1F [ Mus musculus (house mouse) ]

    Gene ID: 232408, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Klrb1fprovided by MGI
    Official Full Name
    killer cell lectin-like receptor subfamily B member 1Fprovided by MGI
    Primary source
    MGI:MGI:2442965
    See related
    Ensembl:ENSMUSG00000030154 AllianceGenome:MGI:2442965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkrp1f; Nkr-p1f; Nkrp1-f; A630024B12Rik
    Summary
    Enables signaling receptor activity. Predicted to be involved in regulation of natural killer cell mediated cytotoxicity. Located in cell surface and plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Klrb1f in Genome Data Viewer
    Location:
    6 F3; 6 63.12 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129022800..129036687)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (129045837..129059724)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC064078 Neighboring gene C-type lectin domain family 2, member f Neighboring gene STARR-seq mESC enhancer starr_17472 Neighboring gene STARR-seq mESC enhancer starr_17473 Neighboring gene STARR-seq mESC enhancer starr_17475 Neighboring gene C-type lectin domain family 2, member e Neighboring gene killer cell lectin-like receptor subfamily B member 1, pseudogene 1 Neighboring gene predicted gene, 53342

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Silencing OCILRP2 leads to intrinsic defects in T cells in response to antigenic stimulation. Tian W, et al. Cell Immunol, 2005 May. PMID 16143319
    2. Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F: crystal structure and biophysical properties. Skálová T, et al. J Immunol, 2012 Nov 15. PMID 23071282
    3. Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells. Adámková L, et al. Int J Mol Sci, 2019 Apr 16. PMID 30995786, Free PMC Article
    4. C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production. Tian W, et al. Cell Immunol, 2005 Mar. PMID 15963483
    5. Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and Nkrp1f. Plougastel B, et al. Immunogenetics, 2001 Sep. PMID 11685472

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nkrp1 isoforms c1, c2 and f were expressed prevalently as homodimers, whereas the Nkrp1a displays larger proportion of monomers on the cell surface.
      Title: Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on Living Cells.
    2. The electrostatic profile of NKR-P1F is complementary to that of Clr-g, which suggests a plausible interaction mechanism based on contacts between surface sites of opposite potential.
      Title: Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F: crystal structure and biophysical properties.
    3. studies reveal a unique functional interaction between two C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T cell costimulation and suggest a role for C-type lectins in maintaining T cell response or memory in vivo
      Title: C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T cell proliferation and IL-2 production.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130065, MGC130066

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of natural killer cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor subfamily B member 1F
    Names
    CD161 antigen-like family member F
    natural killer cell surface protein NKR-P1F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153094.2 → NP_694734.1  killer cell lectin-like receptor subfamily B member 1F

      See identical proteins and their annotated locations for NP_694734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and is protein-coding.
      Source sequence(s)
      AK041601, AK042352, BC127142
      Consensus CDS
      CCDS20579.1
      UniProtKB/Swiss-Prot
      Q1AFZ8, Q3TDT3, Q8C9Q1, Q8VD98
      UniProtKB/TrEMBL
      G4WMX8, I3QI43
      Related
      ENSMUSP00000032257.8, ENSMUST00000032257.10
      Conserved Domains (1) summary
      cd03593
      Location:94 → 212
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RNA

    1. NR_024262.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because it is a nonsense-mediated mRNA decay (NMD) candidate when the 5'-most translation start codon is used, as in variant 1.
      Source sequence(s)
      AK041601, AK042352, BC127141
      Related
      ENSMUST00000203059.3

    2. NR_024263.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because it is a nonsense-mediated mRNA decay (NMD) candidate when the 5'-most translation start codon is used, as in variant 1.
      Source sequence(s)
      AK041601, AK042352, BC107178

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129022800..129036687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321558.1 → XP_017177047.1  killer cell lectin-like receptor subfamily B member 1F isoform X1

      UniProtKB/TrEMBL
      G4WMX8
      Conserved Domains (1) summary
      cd03593
      Location:69 → 187
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    2. XM_006506036.4 → XP_006506099.1  killer cell lectin-like receptor subfamily B member 1F isoform X2

      Conserved Domains (1) summary
      cd03593
      Location:71 → 170
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VD98.1 GenPept UniProtKB/Swiss-Prot:Q8VD98

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