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    kin-32 Inactive tyrosine-protein kinase kin-32 [ Caenorhabditis elegans ]

    Gene ID: 172135, updated on 2-Nov-2024

    Summary

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    Official Symbol
    kin-32
    Official Full Name
    Inactive tyrosine-protein kinase kin-32
    Primary source
    WormBase:WBGene00002213
    Locus tag
    CELE_C30F8.4
    See related
    AllianceGenome:WB:WBGene00002213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation; regulation of cellular component organization; and signal complex assembly. Predicted to be located in cell junction. Predicted to be active in dendritic spine; focal adhesion; and plasma membrane. Is expressed in body wall musculature; head mesodermal cell; head neurons; and reproductive system. Human ortholog(s) of this gene implicated in breast cancer; hypertension; leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to several human genes including PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See kin-32 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (5086310..5093903)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene V-type proton ATPase subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Intraflagellar transport protein 20 homolog Neighboring gene V-type proton ATPase subunit B 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. Di Gregorio E, et al. J Med Genet, 2013 Aug. PMID 23749989, Free PMC Article
    2. Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase. Cram EJ, et al. Dev Dyn, 2008 Mar. PMID 18297732, Free PMC Article
    3. Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components. Nahabedian JF, et al. Methods, 2012 Jan. PMID 22126736, Free PMC Article
    4. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    5. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables non-membrane spanning protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Inactive tyrosine-protein kinase kin-32
    NP_740841.1
    • Confirmed by transcript evidence
    NP_740842.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5086310..5093903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170854.6 → NP_740841.1  Inactive tyrosine-protein kinase kin-32 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T879, Q95YD4
      Conserved Domains (4) summary
      smart00221
      Location:367 → 623
      STYKc; Protein kinase; unclassified specificity
      smart00295
      Location:5 → 230
      B41; Band 4.1 homologues
      cd13190
      Location:226 → 336
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cl21453
      Location:360 → 631
      PKc_like; Protein Kinases, catalytic domain

    2. NM_170855.6 → NP_740842.1  Inactive tyrosine-protein kinase kin-32 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740842.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95YD4
      Conserved Domains (3) summary
      smart00221
      Location:298 → 554
      STYKc; Protein kinase; unclassified specificity
      cd13190
      Location:157 → 267
      FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
      cl21453
      Location:291 → 562
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95YD4.1

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