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    xpo-1 Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179160, updated on 2-Nov-2024

    Summary

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    Official Symbol
    xpo-1
    Official Full Name
    Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00002078
    Locus tag
    CELE_ZK742.1
    See related
    AllianceGenome:WB:WBGene00002078
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nuclear export signal receptor activity. Predicted to be involved in ribosomal large subunit export from nucleus and ribosomal small subunit export from nucleus. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See xpo-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (7805064..7814584)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene UV-stimulated scaffold protein A homolog Neighboring gene ncRNA Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Fatty acid-binding protein homolog 4 Neighboring gene Papilin Neighboring gene EGF-like domain-containing protein Neighboring gene Transthyretin-like protein 33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autoregulation of microRNA biogenesis by let-7 and Argonaute. Zisoulis DG, et al. Nature, 2012 Jun 28. PMID 22722835, Free PMC Article
    2. Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan. Silvestrini MJ, et al. Cell Rep, 2018 May 15. PMID 29768192, Free PMC Article
    3. Exportin 1 modulates life span by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP. Kumar AV, et al. Sci Adv, 2022 Apr. PMID 35363528, Free PMC Article
    4. The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans. Miwa T, et al. Genes Cells, 2022 Oct. PMID 35950937
    5. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear export signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Exportin-1 C-terminal domain-containing protein;Importin N-terminal domain-containing protein
    NP_001367571.1
    • Confirmed by transcript evidence
    NP_741567.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      7805064..7814584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171484.8 → NP_741567.1  Importin N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741567.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23089
      Conserved Domains (1) summary
      COG5101
      Location:22 → 1062
      CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

    2. NM_001380696.1 → NP_001367571.1  Exportin-1 C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPS6
      Conserved Domains (1) summary
      cl07396
      Location:1 → 39
      CRM1_C; CRM1 C terminal
    Nucleotide Protein
    Heading Accession and Version

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