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    Atp8a1 ATPase phospholipid transporting 8A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289615, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Atp8a1provided by RGD
    Official Full Name
    ATPase phospholipid transporting 8A1provided by RGD
    Primary source
    RGD:1309619
    See related
    Ensembl:ENSRNOG00000034200 AllianceGenome:RGD:1309619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylserine flippase activity. Predicted to be involved in learning; positive regulation of cell migration; and regulation of membrane lipid distribution. Is integral component of synaptic vesicle membrane. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 314.3), Lung (RPKM 276.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp8a1 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (40668932..40911465)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (40315013..40557572)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (41972398..42210555)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene glutaredoxin and cysteine rich domain containing 1 Neighboring gene uncharacterized LOC120096602 Neighboring gene uncharacterized LOC134481745 Neighboring gene shisa family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning. Levano K, et al. J Neurochem, 2012 Jan. PMID 22007859, Free PMC Article
    2. ATP8A1 activity and phosphatidylserine transbilayer movement. Soupene E, et al. J Receptor Ligand Channel Res, 2008. PMID 20224745, Free PMC Article
    3. Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases. van der Velden LM, et al. J Biol Chem, 2010 Dec 17. PMID 20947505, Free PMC Article
    4. Role for phospholipid flippase complex of ATP8A1 and CDC50A proteins in cell migration. Kato U, et al. J Biol Chem, 2013 Feb 15. PMID 23269685, Free PMC Article
    5. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylserine flippase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminophospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phospholipid translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phospholipid-translocating ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-transporting ATPase IA
    Names
    ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
    probable phospholipid-transporting ATPase IA
    NP_001413924.1
    XP_006251042.1
    XP_038948654.1
    XP_038948656.1
    XP_038948657.1
    XP_038948658.1
    XP_063128992.1
    XP_063128993.1
    XP_063128994.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426995.2 → NP_001413924.1  phospholipid-transporting ATPase IA

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6AVY6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      40668932..40911465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092730.2 → XP_038948658.1  phospholipid-transporting ATPase IA isoform X4

      UniProtKB/TrEMBL
      A6JDA0
      Related
      ENSRNOP00000097076.1
      Conserved Domains (1) summary
      TIGR01652
      Location:49 → 1096
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    2. XM_063272922.1 → XP_063128992.1  phospholipid-transporting ATPase IA isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZXX6

    3. XM_063272923.1 → XP_063128993.1  phospholipid-transporting ATPase IA isoform X6

    4. XM_039092726.2 → XP_038948654.1  phospholipid-transporting ATPase IA isoform X1

      UniProtKB/TrEMBL
      A6JDA0
      Conserved Domains (1) summary
      TIGR01652
      Location:94 → 1131
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    5. XM_039092729.2 → XP_038948657.1  phospholipid-transporting ATPase IA isoform X3

      UniProtKB/TrEMBL
      A6JDA0
      Conserved Domains (1) summary
      TIGR01652
      Location:94 → 1116
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    6. XM_039092728.2 → XP_038948656.1  phospholipid-transporting ATPase IA isoform X2

      UniProtKB/TrEMBL
      A6JDA0
      Conserved Domains (1) summary
      TIGR01652
      Location:94 → 1131
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

    7. XM_006250980.4 → XP_006251042.1  phospholipid-transporting ATPase IA isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZKC1
      Related
      ENSRNOP00000077596.1
      Conserved Domains (5) summary
      TIGR01484
      Location:489 → 654
      HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
      TIGR01494
      Location:14 → 716
      ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
      pfam13246
      Location:322 → 417
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16212
      Location:663 → 915
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:632 → 661
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    8. XM_063272924.1 → XP_063128994.1  phospholipid-transporting ATPase IA isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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