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    Tmem260 transmembrane protein 260 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361030, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem260provided by RGD
    Official Full Name
    transmembrane protein 260provided by RGD
    Primary source
    RGD:1562018
    See related
    EnsemblRapid:ENSRNOG00000013353 AllianceGenome:RGD:1562018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562018
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in protein maturation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in T-cell non-Hodgkin lymphoma; non-Hodgkin lymphoma; and stomach cancer. Orthologous to human TMEM260 (transmembrane protein 260). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 118.7), Adrenal (RPKM 92.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem260 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (24213658..24287242)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (21734119..21804049)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (25294452..25361623)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554413 Neighboring gene uncharacterized LOC120097124 Neighboring gene uncharacterized LOC102554609 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A polymorphism at the microRNA binding site in the 3'-untranslated region of C14orf101 is associated with the risk of gastric cancer development. Wang C, et al. Exp Ther Med, 2016 Sep. PMID 27602096, Free PMC Article
    2. A polymorphism at the microRNA binding site in the 3' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival. Yang B, et al. Cancer Genet, 2014 Apr. PMID 24831772
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188600

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked mannosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein O-mannosyl-transferase TMEM260
    NP_001163946.2
    XP_038949395.1
    XP_038949398.1
    XP_038949399.1
    XP_038949400.1
    XP_038949402.1
    XP_063130465.1
    XP_063130466.1
    XP_063130467.1
    XP_063130468.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170475.2 → NP_001163946.2  protein O-mannosyl-transferase TMEM260

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AHR0, F1M7C0
      Related
      ENSRNOP00000017871.6, ENSRNOT00000017871.9
      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      24213658..24287242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274395.1 → XP_063130465.1  protein O-mannosyl-transferase TMEM260 isoform X2

    2. XM_039093470.2 → XP_038949398.1  protein O-mannosyl-transferase TMEM260 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJK8, B5DEJ7
      Related
      ENSRNOP00000093081.1, ENSRNOT00000096624.2
      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    3. XM_039093467.2 → XP_038949395.1  protein O-mannosyl-transferase TMEM260 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTW1
      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    4. XM_063274396.1 → XP_063130466.1  protein O-mannosyl-transferase TMEM260 isoform X3

      Related
      ENSRNOP00000082632.1, ENSRNOT00000099556.2

    5. XM_039093472.1 → XP_038949400.1  protein O-mannosyl-transferase TMEM260 isoform X8

      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    6. XM_063274397.1 → XP_063130467.1  protein O-mannosyl-transferase TMEM260 isoform X5

    7. XM_063274398.1 → XP_063130468.1  protein O-mannosyl-transferase TMEM260 isoform X7

    8. XM_039093471.1 → XP_038949399.1  protein O-mannosyl-transferase TMEM260 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZWL8
      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    9. XM_039093474.1 → XP_038949402.1  protein O-mannosyl-transferase TMEM260 isoform X9

      Conserved Domains (1) summary
      pfam11028
      Location:48 → 203
      DUF2723; Protein of unknown function (DUF2723)

    RNA

    1. XR_005493750.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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