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    Kif23 kinesin family member 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315740, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kif23provided by RGD
    Official Full Name
    kinesin family member 23provided by RGD
    Primary source
    RGD:1308596
    See related
    EnsemblRapid:ENSRNOG00000014080 AllianceGenome:RGD:1308596
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including mitotic cytokinesis; mitotic spindle midzone assembly; and positive regulation of cytokinesis. Predicted to be located in several cellular components, including Flemming body; intercellular bridge; and microtubule cytoskeleton. Predicted to be part of centralspindlin complex and kinesin complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type III. Orthologous to human KIF23 (kinesin family member 23). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 180.0), Spleen (RPKM 104.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kif23 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (71293439..71321911, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (62397908..62425162, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (66866043..66893241, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552398 Neighboring gene ribosomal protein lateral stalk subunit P1 Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene glucuronic acid epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. Tomas A, et al. J Cell Biol, 2004 Jun 21. PMID 15197175, Free PMC Article
    2. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Mishima M, et al. Dev Cell, 2002 Jan. PMID 11782313
    3. Characterization of centrosomal proteins Cep55 and pericentrin in intercellular bridges of mouse testes. Chang YC, et al. J Cell Biochem, 2010 Apr 15. PMID 20186884
    4. An ECT2-centralspindlin complex regulates the localization and function of RhoA. Yüce O, et al. J Cell Biol, 2005 Aug 15. PMID 16103226, Free PMC Article
    5. Dissecting the role of Rho-mediated signaling in contractile ring formation. Kamijo K, et al. Mol Biol Cell, 2006 Jan. PMID 16236794, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle midzone assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Flemming body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of centralspindlin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108155.1 → NP_001101625.1  kinesin-like protein KIF23

      See identical proteins and their annotated locations for NP_001101625.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A0A8I6GJ20, A6J569, D4AAG4
      Related
      ENSRNOP00000033647.6, ENSRNOT00000037028.7
      Conserved Domains (4) summary
      cd01368
      Location:24 → 434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31 → 436
      Kinesin; Kinesin motor domain
      pfam16540
      Location:796 → 895
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl12013
      Location:483 → 621
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      71293439..71321911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265498.1 → XP_063121568.1  kinesin-like protein KIF23 isoform X11

    2. XM_063265506.1 → XP_063121576.1  kinesin-like protein KIF23 isoform X20

    3. XM_039081487.2 → XP_038937415.1  kinesin-like protein KIF23 isoform X10

      UniProtKB/TrEMBL
      D4AAG4
      Conserved Domains (3) summary
      PRK03918
      Location:572 → 738
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:79 → 504
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:863 → 892
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    4. XM_063265493.1 → XP_063121563.1  kinesin-like protein KIF23 isoform X3

    5. XM_039081488.2 → XP_038937416.1  kinesin-like protein KIF23 isoform X12

      UniProtKB/TrEMBL
      D4AAG4
      Conserved Domains (3) summary
      PRK03918
      Location:557 → 723
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:79 → 489
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:848 → 877
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    6. XM_063265494.1 → XP_063121564.1  kinesin-like protein KIF23 isoform X5

    7. XM_039081483.2 → XP_038937411.1  kinesin-like protein KIF23 isoform X2

      UniProtKB/TrEMBL
      D4AAG4
      Conserved Domains (3) summary
      PRK03918
      Location:571 → 737
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:79 → 503
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:865 → 967
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    8. XM_039081489.2 → XP_038937417.1  kinesin-like protein KIF23 isoform X13

      UniProtKB/TrEMBL
      D4AAG4
      Conserved Domains (3) summary
      PRK03918
      Location:572 → 738
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:79 → 504
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:762 → 864
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    9. XM_039081482.2 → XP_038937410.1  kinesin-like protein KIF23 isoform X1

      UniProtKB/TrEMBL
      D4AAG4
      Conserved Domains (3) summary
      PRK03918
      Location:572 → 738
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:79 → 504
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:866 → 968
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    10. XM_063265502.1 → XP_063121572.1  kinesin-like protein KIF23 isoform X16

      UniProtKB/TrEMBL
      A0A0G2K7Y7

    11. XM_039081484.2 → XP_038937412.1  kinesin-like protein KIF23 isoform X4

      UniProtKB/TrEMBL
      D4AAG4
      Related
      ENSRNOP00000091527.2, ENSRNOT00000112104.2
      Conserved Domains (3) summary
      PRK03918
      Location:557 → 723
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:79 → 489
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:851 → 953
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    12. XM_063265496.1 → XP_063121566.1  kinesin-like protein KIF23 isoform X6

    13. XM_063265499.1 → XP_063121569.1  kinesin-like protein KIF23 isoform X14

    14. XM_063265505.1 → XP_063121575.1  kinesin-like protein KIF23 isoform X19

    15. XM_063265504.1 → XP_063121574.1  kinesin-like protein KIF23 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZWA3

    16. XM_039081486.2 → XP_038937414.1  kinesin-like protein KIF23 isoform X9

      UniProtKB/TrEMBL
      D4AAG4
      Conserved Domains (3) summary
      PRK03918
      Location:516 → 682
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:24 → 448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:810 → 912
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    17. XM_063265503.1 → XP_063121573.1  kinesin-like protein KIF23 isoform X17

    18. XM_039081485.2 → XP_038937413.1  kinesin-like protein KIF23 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZRP3, D4AAG4
      Related
      ENSRNOP00000074399.3, ENSRNOT00000091755.3
      Conserved Domains (3) summary
      PRK03918
      Location:517 → 683
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd01368
      Location:24 → 449
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam16540
      Location:811 → 913
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    19. XM_063265507.1 → XP_063121577.1  kinesin-like protein KIF23 isoform X21

    20. XM_063265500.1 → XP_063121570.1  kinesin-like protein KIF23 isoform X15

    21. XM_063265497.1 → XP_063121567.1  kinesin-like protein KIF23 isoform X7

      Related
      ENSRNOP00000107493.1, ENSRNOT00000134548.1
    Nucleotide Protein Strain
    Heading Accession and Version

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