U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    icpp-55 Aminopeptidase P N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187899, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    icpp-55
    Official Full Name
    Aminopeptidase P N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00020088
    Locus tag
    CELE_R119.2
    See related
    AllianceGenome:WB:WBGene00020088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable aminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See icpp-55 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (368270..373465, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene pseudo Neighboring gene RRM domain-containing protein Neighboring gene DeHydrogenases, Short chain Neighboring gene Prion-like (glutamine/asparagine-rich) domain bearing protein pqn-59 Neighboring gene Transcription initiation factor TFIID subunit 4 Neighboring gene Protein-L-isoaspartate O-methyltransferase domain-containing protein 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Aminopeptidase P N-terminal domain-containing protein
    NP_001417605.1
    • Confirmed by transcript evidence
    NP_490725.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      368270..373465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058324.5 → NP_490725.3  Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490725.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61710
      Conserved Domains (2) summary
      pfam05195
      Location:20 → 149
      AMP_N; Aminopeptidase P, N-terminal domain
      cl00279
      Location:188 → 427
      APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

    2. NM_001430679.1 → NP_001417605.1  Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools