clh-1 CBS domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: clh-1
Official Full Name: CBS domain-containing protein
Primary source: WormBase:WBGene00000528
Locus tag: CELE_T27D12.2
See related: AllianceGenome:WB:WBGene00000528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable voltage-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including amphid sensillum; cephalic sheath cell; head; hypodermis; and vulva. Human ortholog(s) of this gene implicated in Becker disease; Thomsen disease; idiopathic generalized epilepsy 11; myotonia congenita; and primary hyperaldosteronism. Orthologous to human CLCN1 (chloride voltage-gated channel 1) and CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clh-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 20

Sequence:: Chromosome: II; NC_003280.10 (11846507..11856461, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans.
Title: Roles of the ClC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. elegans.
we describe our discovery that the C. elegans amphid sheath glia regulate intracellular pH via HCO3 (-) flux through the voltage-gated ClC channel CLH-1
Title: A Novel Mechanism of pH Buffering in C. elegans Glia: Bicarbonate Transport via the Voltage-Gated ClC Cl- Channel CLH-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T27D12.2 (e-PCR)
- UniSTS:308132

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables voltage-gated chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated chloride channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CBS domain-containing protein

NP_001022373.1

Confirmed by transcript evidence

NP_001382719.1

Partially confirmed by transcript evidence

NP_001382720.1

Partially confirmed by transcript evidence

NP_001382723.1

Confirmed by transcript evidence

NP_001417598.1

Confirmed by transcript evidence

NP_001417599.1

Confirmed by transcript evidence

NP_001417851.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11846507..11856461 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001430676.1 → NP_001417598.1 CBS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D9MJ86
NM_001430932.1 → NP_001417851.1 CBS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EDQ0
NM_001027202.8 → NP_001022373.1 CBS domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022373.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22833, Q9U6W8

Conserved Domains (3) summary

cd03683
Location:124 → 607

ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...

cd04591
Location:768 → 840

CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...

pfam00654
Location:182 → 585

Voltage_CLC; Voltage gated chloride channel
NM_001395809.1 → NP_001382720.1 CBS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D9MHU6, Q9U6W8

Conserved Domains (2) summary

cd03683
Location:129 → 612

ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...

cd04591
Location:625 → 845

CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
NM_001395810.1 → NP_001382719.1 CBS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D9MJW7, Q9U6W8

Conserved Domains (2) summary

cd03683
Location:191 → 674

ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...

cd04591
Location:687 → 907

CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
NM_001430677.1 → NP_001417599.1 CBS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D9I637
NM_001395813.1 → NP_001382723.1 CBS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8D9I7J7, Q9U6W8

Conserved Domains (2) summary

cd03683
Location:72 → 555

ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...

cd04591
Location:568 → 795

CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria