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    gfm-1 Elongation factor G, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 174956, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gfm-1
    Official Full Name
    Elongation factor G, mitochondrial
    Primary source
    WormBase:WBGene00009246
    Locus tag
    CELE_F29C12.4
    See related
    AllianceGenome:WB:WBGene00009246
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 1. Orthologous to human GFM1 (G elongation factor mitochondrial 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gfm-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (13117483..13122016)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene BTB and MATH domain-containing protein 45 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution. Hammarsund M, et al. Hum Genet, 2001 Nov. PMID 11735030
    2. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans. Emerson FJ, et al. Nat Commun, 2024 Mar 14. PMID 38485937, Free PMC Article
    3. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article
    4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
    5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongation factor G, mitochondrial
    NP_496787.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13117483..13122016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064386.7 → NP_496787.1  Elongation factor G, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496787.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XV52
      Conserved Domains (6) summary
      cd01886
      Location:46 → 318
      EF-G; Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis
      PRK12740
      Location:50 → 730
      PRK12740; elongation factor G; Reviewed
      cd01434
      Location:522 → 639
      EFG_mtEFG1_IV; EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2 ...
      cd04097
      Location:644 → 721
      mtEFG1_C; mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating ...
      cd04091
      Location:350 → 430
      mtEFG1_II_like; Domain II of mitochondrial elongation factor G1-like proteins found in eukaryotes
      cd16262
      Location:444 → 518
      EFG_III; Domain III of Elongation Factor G (EFG)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XV52.1

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