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    for foraging [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44817, updated on 2-Nov-2024

    Summary

    Official Symbol
    forprovided by FlyBase
    Official Full Name
    foragingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000721
    Locus tag
    Dmel_CG10033
    See related
    AllianceGenome:FB:FBgn0000721
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    142251_at; anon-WO0140519.260; anon-WO02059370.47; BcDNA:GM08338; CG10033; dg2; Dg2; DG2; Dmel\CG10033; For; FOR/PKG; l(2)06860; PKG; Pkg2; PKG2; Pkg24A
    Summary
    Enables cGMP-dependent protein kinase activity. Involved in several processes, including larval feeding behavior; learning or memory; and positive regulation of Toll signaling pathway. Located in cytosol and plasma membrane. Is expressed in several structures, including embryonic/larval midgut cell; ganglia; gut section; head epidermis primordium; and synaptic neuropil subdomain. Used to study epilepsy. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See for in Genome Data Viewer
    Location:
    24A2-24A4; 2-10 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3622074..3656953, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3622074..3656953, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44310 Neighboring gene UDP-glycosyltransferase family 36 member A1 Neighboring gene uncharacterized protein Neighboring gene mir-4972 stem loop Neighboring gene Dorsal root ganglia homeobox Neighboring gene Seminal fluid protein 24Ba Neighboring gene Seminal fluid protein 24Bd

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cGMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cGMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cGMP-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    foraging
    Names
    CG10033-PA
    CG10033-PC
    CG10033-PD
    CG10033-PE
    CG10033-PG
    CG10033-PH
    CG10033-PI
    CG10033-PJ
    CG10033-PK
    CG10033-PL
    CG10033-PM
    CG10033-PN
    CG10033-PO
    for-PA
    for-PC
    for-PD
    for-PE
    for-PG
    for-PH
    for-PI
    for-PJ
    for-PK
    for-PL
    for-PM
    for-PN
    for-PO
    NP_001014464.1
    NP_001162858.1
    NP_001334731.1
    NP_001356892.1
    NP_001356896.1
    NP_001356955.1
    NP_477487.1
    NP_477489.1
    NP_477490.1
    NP_599146.1
    NP_995626.1
    NP_995628.1
    NP_995629.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3622074..3656953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205904.2NP_995626.1  foraging, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2
      UniProtKB/TrEMBL
      E1U3G1
      Conserved Domains (5) summary
      cd12085
      Location:385432
      DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha
      smart00220
      Location:7781036
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:632753
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:638754
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:7831043
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    2. NM_001369953.1NP_001356892.1  foraging, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd00038
      Location:118234
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:263523
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    3. NM_058139.4NP_477487.1  foraging, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2
      UniProtKB/TrEMBL
      E1U3G1
      Related
      FBpp0088350
      Conserved Domains (5) summary
      cd12085
      Location:385432
      DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha
      smart00220
      Location:7781036
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:632753
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:638754
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:7831043
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    4. NM_001369954.1NP_001356896.1  foraging, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd00038
      Location:118234
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:263523
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    5. NM_205906.2NP_995628.1  foraging, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995628.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V042, Q03043, Q24304, Q9I7Q1, Q9VQT2
      UniProtKB/TrEMBL
      E1U3G1
      Conserved Domains (5) summary
      cd12085
      Location:385432
      DD_cGKI-alpha; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I alpha
      smart00220
      Location:7781036
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:632753
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:638754
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:7831043
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    6. NM_001347740.1NP_001334731.1  foraging, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1W5Q0S1, E1U3F9
    7. NM_001369955.1NP_001356955.1  foraging, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K344
      Conserved Domains (2) summary
      cd00038
      Location:21137
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:166426
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    8. NM_001014464.2NP_001014464.1  foraging, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V044, A4V046, P32023, Q0E8U1, Q24302, Q24303, Q9I7Q0, Q9I7Q2
      UniProtKB/TrEMBL
      E1U3G0
      Conserved Domains (4) summary
      smart00220
      Location:624882
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:478599
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:484600
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:629889
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    9. NM_058141.4NP_477489.1  foraging, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477489.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHR9, E1U3G2
      Related
      FBpp0088353
      Conserved Domains (4) summary
      smart00220
      Location:584842
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:438559
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:444560
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:589849
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    10. NM_205907.2NP_995629.1  foraging, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHR9, E1U3G2
      Conserved Domains (4) summary
      smart00220
      Location:584842
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:438559
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:444560
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:589849
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    11. NM_134319.4NP_599146.1  foraging, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHR9, E1U3G2
      Related
      FBpp0088354
      Conserved Domains (4) summary
      smart00220
      Location:584842
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:438559
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:444560
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:589849
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    12. NM_058142.4NP_477490.1  foraging, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V044, A4V046, P32023, Q0E8U1, Q24302, Q24303, Q9I7Q0, Q9I7Q2
      UniProtKB/TrEMBL
      E1U3G0
      Related
      FBpp0088352
      Conserved Domains (4) summary
      smart00220
      Location:624882
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:478599
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:484600
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:629889
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    13. NM_001169387.2NP_001162858.1  foraging, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162858.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHR9, E1U3G2
      Conserved Domains (4) summary
      smart00220
      Location:584842
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0664
      Location:438559
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:444560
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:589849
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)