RO60 Ro60, Y RNA binding protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: RO60provided by HGNC
Official Full Name: Ro60, Y RNA binding proteinprovided by HGNC
Primary source: HGNC:HGNC:11313
See related: Ensembl:ENSG00000116747 MIM:600063; AllianceGenome:HGNC:11313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SSA2; RORNP; TROVE2
Summary: Enables RNA binding activity. Involved in cellular response to interferon-alpha and regulation of gene expression. Located in cytosol and nuclear body. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in brain (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q31.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (193059612..193091777)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (192406634..192438985)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (193028742..193060907)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
Title: IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus.
Identification of a unique anti-Ro60 subset with restricted serological and molecular profiles.
Title: Identification of a unique anti-Ro60 subset with restricted serological and molecular profiles.
Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner.
Title: Noncoding Y RNAs regulate the levels, subcellular distribution and protein interactions of their Ro60 autoantigen partner.
Because the Ro60 ribonucleoprotein (RNP) is a clinically important target of autoantibodies in patients with rheumatic diseases such as Sjogren's syndrome, systemic lupus erythematosus, and neonatal lupus, this review discusses potential roles for Ro60 RNPs in the initiation and pathogenesis of systemic autoimmune rheumatic disease. [review]
Title: Ro60 and Y RNAs: structure, functions, and roles in autoimmunity.
strengthens the anti-inflammatory effect via macrophage polarization by estrogen induction in abdominal aortic aneurysm
Title: TROVE2 strengthens the anti-inflammatory effect via macrophage polarization by estrogen induction in abdominal aortic aneurysm.
TROVE2 is a novel target of miR-128 in astrocytoma tissues and the expression of TROVE2 is increased with the pathological stages increasing.
Title: Expression Profile of MiR-128 in the Astrocytoma Patients and Cell Lines.
Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La.
Title: Association of anti-Ro52, anti-Ro60 and anti-La antibodies with diagnostic, clinical and laboratory features in a referral hospital in Jerez, Spain.
These findings establish a link among the lupus autoantigen Ro60, Alu retroelements, and type I interferon.
Title: The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.
Findings indicate a relentless turnover of short-lived clonotypic variants, masquerading as long-lived Ro60 humoral autoimmunity.
Title: Long-term Ro60 humoral autoimmunity in primary Sjögren's syndrome is maintained by rapid clonal turnover.
The Y3 RNA moiety of the Ro60 ribonucleoprotein plays a critical role in the pathogenesis of fetal cardiac injury by altering the subcellular location of Ro60 autoantibodies.
Title: Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH66393 (e-PCR)
- UniSTS:13840

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-76068 (e-PCR)
- UniSTS:10302

SHGC-76062 (e-PCR)
- UniSTS:14430

SHGC-76067 (e-PCR)
- UniSTS:76170

G42189 (e-PCR)
- UniSTS:105107

SHGC-76066 (e-PCR)
- UniSTS:74141

D1S3172 (e-PCR)
- UniSTS:41120

L17809 (e-PCR)
- UniSTS:39087

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U2 snRNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in immune system development	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in response to UV	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase III	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: RNA-binding protein RO60

Names: 60 kDa ribonucleoprotein Ro; Ro/SSA 60kDa; Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro); TROVE domain family member 2; gastric cancer multi-drug resistance protein; ro60 autoantigen; sjoegren syndrome type A antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042369.2 → NP_001035828.1 RNA-binding protein RO60 isoform 1

See identical proteins and their annotated locations for NP_001035828.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AI433657, CX761715, M25077

Consensus CDS

CCDS41449.1

UniProtKB/Swiss-Prot

P10155

Related

ENSP00000356414.3, ENST00000367444.7

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:370 → 505

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001042370.2 → NP_001035829.2 RNA-binding protein RO60 isoform 3

See identical proteins and their annotated locations for NP_001035829.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AI433657, AL136370, AY205315, CX761715

Consensus CDS

CCDS41450.2

UniProtKB/Swiss-Prot

P10155

Related

ENSP00000356415.3, ENST00000367445.7

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001173524.2 → NP_001166995.1 RNA-binding protein RO60 isoform 2

See identical proteins and their annotated locations for NP_001166995.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, the 3' coding region and the 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1. Variants 2 and 5 encode the same isoform (2).

Source sequence(s)

AK314594, AL136370, BC036658, M25077

Consensus CDS

CCDS1379.1

UniProtKB/Swiss-Prot

B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6

Related

ENSP00000383752.2, ENST00000400968.7

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001173525.1 → NP_001166996.1 RNA-binding protein RO60 isoform 4

See identical proteins and their annotated locations for NP_001166996.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AI433657, AL136370, AY205314, CX761715

Consensus CDS

CCDS53451.1

UniProtKB/Swiss-Prot

P10155

Related

ENSP00000356413.1, ENST00000367443.5

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:370 → 505

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
NM_001331020.2 → NP_001317949.1 RNA-binding protein RO60 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and has a longer and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL136370

Consensus CDS

CCDS86042.1

UniProtKB/TrEMBL

A0A024R941, A0A9K3Y7X9, G5E9R9

Related

ENSP00000472298.1, ENST00000432079.5

Conserved Domains (2) summary

cd00198
Location:97 → 214

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam05731
Location:1 → 94

TROVE; TROVE domain
NM_004600.5 → NP_004591.2 RNA-binding protein RO60 isoform 2

See identical proteins and their annotated locations for NP_004591.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1.

Source sequence(s)

AL136370, BC036658, CX761715

Consensus CDS

CCDS1379.1

UniProtKB/Swiss-Prot

B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6

Related

ENSP00000356416.3, ENST00000367446.7

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

193059612..193091777

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047428924.1 → XP_047284880.1 RNA-binding protein RO60 isoform X2

UniProtKB/Swiss-Prot

B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6
XM_006711496.4 → XP_006711559.1 RNA-binding protein RO60 isoform X1

See identical proteins and their annotated locations for XP_006711559.1

Conserved Domains (2) summary

pfam05731
Location:17 → 391

TROVE; TROVE domain

cl00057
Location:392 → 527

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_006711497.4 → XP_006711560.1 RNA-binding protein RO60 isoform X2

See identical proteins and their annotated locations for XP_006711560.1

UniProtKB/Swiss-Prot

B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_011509922.3 → XP_011508224.1 RNA-binding protein RO60 isoform X3

See identical proteins and their annotated locations for XP_011508224.1

UniProtKB/TrEMBL

A0A024R941, A0A9K3Y7X9, G5E9R9

Conserved Domains (2) summary

cd00198
Location:97 → 214

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam05731
Location:1 → 94

TROVE; TROVE domain
XM_006711495.5 → XP_006711558.1 RNA-binding protein RO60 isoform X1

See identical proteins and their annotated locations for XP_006711558.1

Conserved Domains (2) summary

pfam05731
Location:17 → 391

TROVE; TROVE domain

cl00057
Location:392 → 527

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_017002183.2 → XP_016857672.1 RNA-binding protein RO60 isoform X3

UniProtKB/TrEMBL

A0A024R941, A0A9K3Y7X9, G5E9R9

Conserved Domains (2) summary

cd00198
Location:97 → 214

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

pfam05731
Location:1 → 94

TROVE; TROVE domain
XM_047428920.1 → XP_047284876.1 RNA-binding protein RO60 isoform X1
XM_017002181.3 → XP_016857670.1 RNA-binding protein RO60 isoform X2

UniProtKB/Swiss-Prot

B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_017002180.2 → XP_016857669.1 RNA-binding protein RO60 isoform X1

Conserved Domains (2) summary

pfam05731
Location:17 → 391

TROVE; TROVE domain

cl00057
Location:392 → 527

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_017002182.2 → XP_016857671.1 RNA-binding protein RO60 isoform X2

UniProtKB/Swiss-Prot

B2RBB9, P10155, Q5LJ98, Q5LJ99, Q5LJA0, Q86WL3, Q86WL4, Q92787, Q9H1W6

Conserved Domains (2) summary

pfam05731
Location:17 → 369

TROVE; TROVE domain

cl00057
Location:372 → 489

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...