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    map3k7.S mitogen-activated protein kinase kinase kinase 7 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 379399, updated on 4-Nov-2024

    Summary

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    Official Symbol
    map3k7.S
    Official Full Name
    mitogen-activated protein kinase kinase kinase 7 S homeolog
    Primary source
    Xenbase:XB-GENE-17339869
    Locus tag
    XELAEV_18029365mg
    See related
    EnsemblRapid:ENSXLAG00005002969 AllianceGenome:Xenbase:XB-GENE-17339869
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    tak1; xTAK1; MAPKKK
    Summary
    Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to act upstream of or within several processes, including JNK cascade; positive regulation of canonical NF-kappaB signal transduction; and protein phosphorylation. Predicted to be located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See map3k7.S in Genome Data Viewer
    Location:
    chromosome: 5S
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (72541529..72601921)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (67867002..67927632)

    Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 9 (alpha (1,3) fucosyltransferase) S homeolog Neighboring gene EPH receptor A7 S homeolog Neighboring gene uncharacterized LOC121394249 Neighboring gene BTB domain and CNC homolog 2 S homeolog Neighboring gene gap junction protein alpha 10 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC53150

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 7 S homeolog
    Names
    Mitogen-activated protein kinase kinase kinase 7-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001086243.1 → NP_001079712.1  mitogen-activated protein kinase kinase kinase 7 S homeolog

      See identical proteins and their annotated locations for NP_001079712.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049005
      UniProtKB/TrEMBL
      A0A974HHH2, Q801N1
      Conserved Domains (2) summary
      smart00219
      Location:25 → 273
      TyrKc; Tyrosine kinase, catalytic domain
      cd14058
      Location:31 → 281
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      72541529..72601921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041563898.1 → XP_041419832.1  mitogen-activated protein kinase kinase kinase 7 S homeolog isoform X3

      UniProtKB/TrEMBL
      A0A8J1KR76, A0A974HHH2
      Related
      ENSXLAP00005008946.1, ENSXLAT00005009070.1
      Conserved Domains (1) summary
      cd14058
      Location:31 → 281
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    2. XM_041563899.1 → XP_041419833.1  mitogen-activated protein kinase kinase kinase 7 S homeolog isoform X4

      UniProtKB/TrEMBL
      A0A8J1KSV2, A0A974HHH2
      Conserved Domains (1) summary
      cd14058
      Location:31 → 281
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    3. XM_041563896.1 → XP_041419830.1  mitogen-activated protein kinase kinase kinase 7 S homeolog isoform X1

      UniProtKB/TrEMBL
      A0A8J1KRA8, A0A974HHH2
      Related
      ENSXLAP00005008915.1, ENSXLAT00005009042.1
      Conserved Domains (1) summary
      cd14058
      Location:31 → 281
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    4. XM_041563897.1 → XP_041419831.1  mitogen-activated protein kinase kinase kinase 7 S homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J1KR95, A0A974HHH2
      Related
      ENSXLAP00005008934.1, ENSXLAT00005009060.1
      Conserved Domains (1) summary
      cd14058
      Location:31 → 281
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1

    5. XM_041563900.1 → XP_041419834.1  mitogen-activated protein kinase kinase kinase 7 S homeolog isoform X5

      UniProtKB/TrEMBL
      A0A8J1KUD5, A0A974HHH2
      Conserved Domains (1) summary
      cd14058
      Location:1 → 189
      STKc_TAK1; Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1
    Nucleotide Protein Strain
    Heading Accession and Version

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