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    NAIP NLR family apoptosis inhibitory protein [ Bos taurus (domestic cattle) ]

    Gene ID: 539780, updated on 4-Oct-2024

    Summary

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    Official Symbol
    NAIPprovided by VGNC
    Official Full Name
    NLR family apoptosis inhibitory proteinprovided by VGNC
    Primary source
    VGNC:VGNC:31873
    See related
    Ensembl:ENSBTAG00000003326
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human all
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    Genomic context

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    See NAIP in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (10145062..10187275, complement)

    Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene small EDRK-rich factor 1A (telomeric) Neighboring gene survival of motor neuron 2, centromeric Neighboring gene general transcription factor IIH, polypeptide 2, 44kDa Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene occludin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in detection of bacterium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pyroptotic inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IPAF inflammasome complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    baculoviral IAP repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      10145062..10187275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010816709.4 → XP_010815011.1  baculoviral IAP repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      E1BEJ9
      Conserved Domains (5) summary
      smart00382
      Location:467 → 604
      AAA; ATPases associated with a variety of cellular activities
      cd00022
      Location:286 → 351
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00034
      Location:1294 → 1322
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00653
      Location:163 → 229
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:468 → 622
      NACHT; NACHT domain

    2. XM_059878856.1 → XP_059734839.1  baculoviral IAP repeat-containing protein 1 isoform X1

    3. XM_015459053.3 → XP_015314539.1  baculoviral IAP repeat-containing protein 1 isoform X3

      Conserved Domains (3) summary
      cd00022
      Location:61 → 126
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00034
      Location:1069 → 1097
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:243 → 397
      NACHT; NACHT domain

    4. XM_024981436.2 → XP_024837204.1  baculoviral IAP repeat-containing protein 1 isoform X3

      Conserved Domains (3) summary
      cd00022
      Location:61 → 126
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00034
      Location:1069 → 1097
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:243 → 397
      NACHT; NACHT domain

    5. XM_059878858.1 → XP_059734841.1  baculoviral IAP repeat-containing protein 1 isoform X4

    6. XM_024981437.2 → XP_024837205.1  baculoviral IAP repeat-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E1BEJ9
      Related
      ENSBTAP00000004317.6, ENSBTAT00000004317.6
      Conserved Domains (3) summary
      cd00022
      Location:46 → 111
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00034
      Location:1054 → 1082
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:228 → 382
      NACHT; NACHT domain

    7. XM_059878859.1 → XP_059734842.1  baculoviral IAP repeat-containing protein 1 isoform X6

    8. XM_059878857.1 → XP_059734840.1  baculoviral IAP repeat-containing protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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