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    ldlr low density lipoprotein receptor [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100495826, updated on 8-Mar-2024

    Summary

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    Official Symbol
    ldlrprovided by Xenbase
    Official Full Name
    low density lipoprotein receptorprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-962372
    See related
    Ensembl:ENSXETG00000009352
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    fhc; ldlcq2; ldlr-a; ldlr-b
    Orthologs
    human mouse all
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    Genomic context

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    See ldlr in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (138972462..138986944)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (128127800..128142355)

    Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene uncharacterized LOC116409502 Neighboring gene uncharacterized LOC116409824 Neighboring gene KN motif and ankyrin repeat domains 2 Neighboring gene dedicator of cytokinesis 6 Neighboring gene golgin subfamily A member 6-like protein 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      138972462..138986944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002942845.5 → XP_002942891.1  low-density lipoprotein receptor

      UniProtKB/TrEMBL
      A0A6I8SL03, F7EGG3
      Related
      ENSXETP00000098188.1, ENSXETT00000085982.2
      Conserved Domains (7) summary
      smart00135
      Location:555 → 595
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:354 → 384
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:111 → 145
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00058
      Location:529 → 569
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam00057
      Location:195 → 231
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:318 → 352
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00104
      Location:278 → 308
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    Nucleotide Protein Strain
    Heading Accession and Version

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