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    POU5F1P4 POU class 5 homeobox 1 pseudogene 4 [ Homo sapiens (human) ]

    Gene ID: 645682, updated on 2-Nov-2024

    Summary

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    Official Symbol
    POU5F1P4provided by HGNC
    Official Full Name
    POU class 5 homeobox 1 pseudogene 4provided by HGNC
    Primary source
    HGNC:HGNC:33310
    See related
    Ensembl:ENSG00000237872 AllianceGenome:HGNC:33310
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCT3; OCT4; OTF3; OTF-3; Oct-3; Oct-4; POU5F1; Oct4-pg4; POU5FLC1
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See POU5F1P4 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155433180..155434262)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154571739..154572821)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155402971..155404053)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155386104-155386607 Neighboring gene RNA, U6 small nuclear 1297, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:155469805-155470306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155484783-155485282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155499969-155500470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155515470-155515970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1817 Neighboring gene Sharpr-MPRA regulatory region 11909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1407 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:155532613-155533180 Neighboring gene Sharpr-MPRA regulatory region 7926 Neighboring gene uncharacterized LOC101929703 Neighboring gene ASH1L antisense RNA 1 Neighboring gene misato mitochondrial distribution and morphology regulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma. Wang L, et al. Carcinogenesis, 2013 Aug. PMID 23615404
    2. Oct4 and its pseudogenes confuse stem cell research. Liedtke S, et al. Cell Stem Cell, 2007 Oct 11. PMID 18371374
    3. Stem cell regulatory function mediated by expression of a novel mouse Oct4 pseudogene. Lin H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17280643
    4. Expression and differentiation between OCT4A and its Pseudogenes in human ESCs and differentiated adult somatic cells. Jez M, et al. PLoS One, 2014. PMID 24586860, Free PMC Article
    5. Differential expression of Oct4 variants and pseudogenes in normal urothelium and urothelial cancer. Wezel F, et al. Am J Pathol, 2013 Oct. PMID 23933063

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OCT4-pg4 functions as a natural micro RNA sponge to protect OCT4 transcript from being inhibited by miR-145.
      Title: Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Other Names

    • Octamer-binding protein 3
    • Octamer-binding protein 4
    • Octamer-binding transcription factor 3
    • POU domain class 5, transcription factor 1 pseudogene 4
    • POU domain transcription factor OCT4-pg4
    • POU domain, class 5, transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_034180.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF268613, AL139410
      Related
      ENST00000413175.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      155433180..155434262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      154571739..154572821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_005794.4: Suppressed sequence

      Description
      NG_005794.4: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.

    2. NG_027152.1: Suppressed sequence

      Description
      NG_027152.1: This RefSeq was suppressed permanently because the locus appears to be transcribed and the RNA is represented by NR_034180.
    Nucleotide Protein
    Heading Accession and Version

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