Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adh7provided by MGI
Official Full Name: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptideprovided by MGI
Primary source: MGI:MGI:87926
See related: Ensembl:ENSMUSG00000055301 AllianceGenome:MGI:87926
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adh3; Adh4; Adh-3; Adt-1; Adh-3e; Adh-3t; Adh3-e; Adh3-t
Summary: Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within ethanol catabolic process; retinoic acid metabolic process; and retinol metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including branchial arch; embryo mesenchyme; endocrine gland; genitourinary system; and neural fold. Used to study Parkinson's disease. Orthologous to human ADH7 (alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 7.8), stomach adult (RPKM 6.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 64.13 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (137903828..137937803)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (138198064..138232042)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADH3 promotes liver fibrosis by enhancing hepatic stellate cell activation and inhibiting natural killer cell activity
Title: Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice.
Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3
Title: Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3.
Cellular expression of Adh3 in the GUI tract was studied.
Title: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease.
ADH1 functions as the primary enzyme responsible for efficient oxidative clearance of excess retinol, thus providing protection and increased survival during vitamin A toxicity, ADH3 plays a secondary role
Title: Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

Adh7 (e-PCR), detects polymorphism
- UniSTS:470548

Adh4 (e-PCR), detects polymorphism
- UniSTS:186487

Adh7 (e-PCR), detects polymorphism
- UniSTS:461947

AI325182 (e-PCR)
- UniSTS:178941

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables alcohol dehydrogenase (NAD+) activity	TAS Traceable Author Statement more info	PubMed
enables aldehyde oxidase activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables ethanol binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables omega-hydroxydecanoate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	TAS Traceable Author Statement more info	PubMed
enables receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables retinol binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ethanol catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ethanol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid omega-oxidation	ISO Inferred from Sequence Orthology more info
involved_in response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinoic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: all-trans-retinol dehydrogenase [NAD(+)] ADH7

Names: ADH-C2; IV ADH; alcohol dehydrogenase 3 complex; alcohol dehydrogenase 3 temporal; alcohol dehydrogenase 4; alcohol dehydrogenase class 4 mu/sigma chain; alcohol dehydrogenase class IV mu/sigma chain; gastric alcohol dehydrogenase; omega-hydroxydecanoate dehydrogenase ADH7; retinol dehydrogenase

NP_033756.2

EC 1.1.1.1

EC 1.1.1.105

EC 1.1.1.66

XP_006500982.1

EC 1.1.1.1

EC 1.1.1.105

EC 1.1.1.66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009626.4 → NP_033756.2 all-trans-retinol dehydrogenase [NAD(+)] ADH7

See identical proteins and their annotated locations for NP_033756.2

Status: VALIDATED

Source sequence(s)

AF331802, BQ560660

Consensus CDS

CCDS38651.1

UniProtKB/Swiss-Prot

Q64437

UniProtKB/TrEMBL

Q3UMM7, Q9D748

Related

ENSMUSP00000087633.6, ENSMUST00000090171.7

Conserved Domains (1) summary

cd08299
Location:3 → 374

alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

137903828..137937803

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500919.4 → XP_006500982.1 all-trans-retinol dehydrogenase [NAD(+)] ADH7 isoform X1

See identical proteins and their annotated locations for XP_006500982.1

UniProtKB/Swiss-Prot

Q64437

UniProtKB/TrEMBL

Q3UMM7, Q9D748

Conserved Domains (1) summary

cd08299
Location:3 → 374

alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases