Brwd1 bromodomain and WD repeat domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brwd1provided by MGI
Official Full Name: bromodomain and WD repeat domain containing 1provided by MGI
Primary source: MGI:MGI:1890651
See related: Ensembl:ENSMUSG00000022914 AllianceGenome:MGI:1890651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr9; repro5; G1-403-16; 5330419I02Rik; D530019K20Rik
Summary: Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human BRWD1 (bromodomain and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 12.4), CNS E11.5 (RPKM 12.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 56.77 cM

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (95793289..95883905, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (95992089..96082703, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study data indicate that, in both mice and humans, BRWD1 is a master orchestrator of enhancer accessibility that cooperates with transcription factor networks to drive late B-cell development.
Title: BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis.
BRWD1 is essential in females for epigenetic control of meiotic chromosome stability and in males for haploid gene transcription during postmeiotic sperm differentiation.
Title: Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability.
Brwd1 represents one of a small number of genes whose elimination disrupts gametogenesis in both sexes after the major events of meiotic prophase I have been completed.
Title: The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition.
WDR9 is a transcriptional regulator involved in chromatin remodeling through the action of two bromodomains and contacts to the SWI/SNF complex
Title: Expression of the Wdr9 gene and protein products during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Brwd1 (e-PCR), detects polymorphism
- UniSTS:478990

Wdr9 (e-PCR), detects polymorphism
- UniSTS:259172

G67837 (e-PCR)
- UniSTS:228484

G67838 (e-PCR)
- UniSTS:228485

G67840 (e-PCR)
- UniSTS:228487

G67835 (e-PCR)
- UniSTS:226193

G67836 (e-PCR)
- UniSTS:226194

ECD17717 (e-PCR)
- UniSTS:298729

5330419I02Rik (e-PCR), detects polymorphism
- UniSTS:259575

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain and WD repeat-containing protein 1

Names: WD repeat domain 9; WD repeat-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103179.1 → NP_001096649.1 bromodomain and WD repeat-containing protein 1 isoform B

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and CDS compared to variant 1. The resulting isoform (B) is shorter and has a unique C-terminus compared to isoform A.

Source sequence(s)

AJ292468, AK030493, AK051870, AK162170, CA561282, CF162350, CV558558

UniProtKB/Swiss-Prot

Q921C3

UniProtKB/TrEMBL

Q3TSA7, Q8BPZ1

Conserved Domains (5) summary

cd05496
Location:1317 → 1433

Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...

cd05529
Location:1150 → 1265

Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...

COG2319
Location:181 → 540

WD40; WD40 repeat [General function prediction only]

cd00200
Location:178 → 497

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:189 → 226

7WD40; WD40 repeat [structural motif]
NM_145125.3 → NP_660107.2 bromodomain and WD repeat-containing protein 1 isoform A

See identical proteins and their annotated locations for NP_660107.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).

Source sequence(s)

AJ292467, AK027961, AK030493, AK051870, AW542089, CF162350, CV558558

Consensus CDS

CCDS49923.1

UniProtKB/Swiss-Prot

E9QAC1, Q921C2, Q921C3

Related

ENSMUSP00000097101.3, ENSMUST00000099502.9

Conserved Domains (5) summary

cd05496
Location:1317 → 1433

Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...

cd05529
Location:1150 → 1265

Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...

COG2319
Location:181 → 540

WD40; WD40 repeat [General function prediction only]

cd00200
Location:178 → 497

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:189 → 226

7WD40; WD40 repeat [structural motif]
NM_176928.1 → NP_795902.1 bromodomain and WD repeat-containing protein 1 isoform C

See identical proteins and their annotated locations for NP_795902.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and CDS compared to variant 1. The resulting isoform (C) is much shorter and has a unique C-terminus compared to isoform A.

Source sequence(s)

AK051870, BB272960

Consensus CDS

CCDS49922.1

UniProtKB/TrEMBL

Q8BPZ1

Related

ENSMUSP00000109458.2, ENSMUST00000113827.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

95793289..95883905 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523113.3 → XP_006523176.1 bromodomain and WD repeat-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006523176.1

Related

ENSMUSP00000023631.9, ENSMUST00000023631.17

Conserved Domains (5) summary

cd05496
Location:1317 → 1433

Bromo_WDR9_II; Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...

cd05529
Location:1150 → 1265

Bromo_WDR9_I_like; Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional ...

cd00200
Location:178 → 497

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:189 → 226

7WD40; WD40 repeat [structural motif]

pfam15402
Location:2334 → 2507

Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7